CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3

FEBS Letters

Volumn 587, Issue 18, 2013, Pages 3038-3044

  Malik, Bhavna ^a   Hemenway, Charles S ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

ENaC ; Gene regulation; Histone methylation; Polycomb group protein

Indexed keywords

BMI1 PROTEIN; DOT1L PROTEIN; HISTONE METHYLTRANSFERASE; MESSENGER RNA; POLYCOMB GROUP PROTEIN; PROTEIN AF9; PROTEIN CBX8; PROTEIN RING1A; PROTEIN RING1B; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CELL STRAIN HEK293; COMPLEX FORMATION; CONTROLLED STUDY; EPITHELIAL SODIUM CHANNEL GENE ALPHA; GENE; GENE EXPRESSION REGULATION; GENE REPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; UPREGULATION;

CARBOXY-TERMINAL DOMAIN; CHIP; CHROMATIN IMMUNOPRECIPITATION; CTD; ENACΑ; GENE REGULATION; H3K79; HISTONE 3 LYSINE 79; HISTONE METHYLATION; PCG; PCG REPRESSIVE COMPLEX 1; POLYCOMB GROUP; POLYCOMB-GROUP PROTEIN; PRC1; QRT-PCR; QUANTITATIVE REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SHORT-HAIRPIN RNA; SHRNA;

CELL LINE, TUMOR; EPITHELIAL SODIUM CHANNELS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; METHYLTRANSFERASES; NUCLEAR PROTEINS; POLYCOMB REPRESSIVE COMPLEX 1; POLYCOMB-GROUP PROTEINS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84883489766     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.07.034     Document Type: Article

References (27)

1. S. Iida, M. Seto, K. Yamamoto, H. Komatsu, A. Tojo, S. Asano, N. Kamada, Y. Ariyoshi, T. Takahashi, and R. Ueda MLLT3 gene on 9p22 involved in t(9; 11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13 Oncogene 8 1993 3085 3092
2. J.M. Schulze, A.Y. Wang, and M.S. Kobor YEATS domain proteins: a diverse family with many links to chromatin modification and transcription Biochem. Cell Biol. 87 2009 65 75
3. T. Nakamura, H. Alder, Y. Gu, R. Prasad, O. Canaani, N. Kamada, R.P. Gale, B. Lange, W.M. Crist, and P.C. Nowell Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs Proc. Natl. Acad. Sci. U. S. A. 90 1993 4631 4635
4. E.C. Collins, A. Appert, L. Ariza-McNaughton, R. Pannell, Y. Yamada, and T.H. Rabbitts Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia Mol. Cell Biol. 22 2002 7313 7324
5. C. Pina, G. May, S. Soneji, D. Hong, and T. Enver MLLT3 regulates early human erythroid and megakaryocytic cell fate Cell Stem Cell 2 2008 264 273
6. A. Cozzio, E. Passegue, P.M. Ayton, H. Karsunky, M.L. Cleary, and I.L. Weissman Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors Genes Dev. 17 2003 3029 3035
7. W. Chen, A.R. Kumar, W.A. Hudson, Q. Li, B. Wu, R.A. Staggs, E.A. Lund, T.N. Sam, and J.H. Kersey Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells Cancer Cell 13 2008 432 440
8. W. Zhang, X. Xia, M.R. Reisenauer, C.S. Hemenway, and B.C. Kone Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner J. Biol. Chem. 281 2006 18059 18068
9. N. Buttner, S.A. Johnsen, S. Kugler, and T. Vogel Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex Proc. Natl. Acad. Sci. U. S. A. 107 2010 7042 7047
10. N. He, M. Liu, J. Hsu, Y. Xue, S. Chou, A. Burlingame, N.J. Krogan, T. Alber, and Q. Zhou HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription Mol. Cell 38 2010 428 438
11. B. Sobhian, N. Laguette, A. Yatim, M. Nakamura, Y. Levy, R. Kiernan, and M. Benkirane HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP Mol. Cell 38 2010 439 451
12. D.J. Steger, M.I. Lefterova, L. Ying, A.J. Stonestrom, M. Schupp, D. Zhuo, A.L. Vakoc, J.E. Kim, J. Chen, M.A. Lazar, G.A. Blobel, and C.R. Vakoc DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells Mol. Cell Biol. 28 2008 2825 2839
13. D. Biswas, T.A. Milne, V. Basrur, J. Kim, K.S. Elenitoba-Johnson, C.D. Allis, and R.G. Roeder Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes Proc. Natl. Acad. Sci. U. S. A. 108 2011 15751 15756
14. F. Erfurth, C.S. Hemenway, A.C. de Erkenez, and P.H. Domer MLL fusion partners AF4 and AF9 interact at subnuclear foci Leukemia 18 2004 92 102
15. E. Bitoun, P.L. Oliver, and K.E. Davies The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling Hum. Mol. Genet. 16 2007 92 106
16. D. Mueller, M.P. Garcia-Cuellar, C. Bach, S. Buhl, E. Maethner, and R.K. Slany Misguided transcriptional elongation causes mixed lineage leukemia PLoS Biol. 7 2009 e1000249
17. C.S. Hemenway, A.C. de Erkenez, and G.C. Gould The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9; 11)(p22; q23) acute leukemias Oncogene 20 2001 3798 3805
18. C.S. Hemenway, B.W. Halligan, and L.S. Levy The Bmi-1 oncoprotein interacts with dinG and MPh2: the role of RING finger domains Oncogene 16 1998 2541 2547
19. R.S. Srinivasan, A.C. de Erkenez, and C.S. Hemenway The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor Oncogene 22 2003 3395 3406
20. D. Mueller, C. Bach, D. Zeisig, M.P. Garcia-Cuellar, S. Monroe, A. Sreekumar, R. Zhou, A. Nesvizhskii, A. Chinnaiyan, J.L. Hess, and R.K. Slany A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification Blood 110 2007 4445 4454
21. A. Yokoyama, M. Lin, A. Naresh, I. Kitabayashi, and M.L. Cleary A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Cancer Cell. 17 2010 198 212
22. L. Morey, G. Pascual, L. Cozzuto, G. Roma, A. Wutz, S.A. Benitah, and L. Di Croce Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells Cell Stem Cell 10 2012 47 62
23. E. Bernstein, E.M. Duncan, O. Masui, J. Gil, E. Heard, and C.D. Allis Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin Mol. Cell Biol. 26 2006 2560 2569
24. M. de Napoles, J.E. Mermoud, R. Wakao, Y.A. Tang, M. Endoh, R. Appanah, T.B. Nesterova, J. Silva, A.P. Otte, M. Vidal, H. Koseki, and N. Brockdorff Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation Dev. Cell 7 2004 663 676
25. B.I. Leach, A. Kuntimaddi, C.R. Schmidt, T. Cierpicki, S.A. Johnson, and J.H. Bushweller Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding Structure 21 2013 176 183
26. J. Tan, M. Jones, H. Koseki, M. Nakayama, A.G. Muntean, I. Maillard, and J.L. Hess CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis Cancer Cell 20 2011 563 575.
27. E. Maethner, M. Garcia-Cuellar, C. Breitinger, S. Takacova, V. Divoky, J.L. Hess, and R.K. Slany MLL-ENL inhibits Polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells Cell Reports 3 2013 1 14