Effect of high dose intravenous vitamin C on idiopathic sudden sensorineural hearing loss: A prospective single-blind randomized controlled trial

European Archives of Oto-Rhino-Laryngology

Volumn 270, Issue 10, 2013, Pages 2631-2636

  Kang, Hung Soo ^a   Park, Jung Je ^b   Ahn, Seong Ki ^b   Hur, Dong Gu ^b   Kim, Ho Yeop ^b  

^a Yeil ENT   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

Author keywords

Antioxidants; Ascorbic acid; Steroids; Sudden hearing loss

Indexed keywords

ASCORBIC ACID; STEROID;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG SAFETY; HUMAN; IDIOPATHIC DISEASE; PERCEPTION DEAFNESS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PURE TONE AUDIOMETRY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TREATMENT OUTCOME; VITAMIN INTAKE;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ADRENAL CORTEX HORMONES; ADULT; AGED; ANTIOXIDANTS; ASCORBIC ACID; AUDIOMETRY, PURE-TONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; HEARING LOSS, SUDDEN; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 84883489501     PISSN: 09374477     EISSN: 14344726     Source Type: Journal    
DOI: 10.1007/s00405-012-2294-y     Document Type: Article

References (20)

1. Hatano M, Uramoto N, Okabe Y, Furukawa M, Ito M (2008) Vitamin E and vitamin C in the treatment of idiopathic sudden sensorineural hearing loss. Acta Otolaryngol 128(2):116-121
2. Joachims HZ, Segal J, Golz A, Netzer A, Goldenberg D (2003) Antioxidants in treatment of idiopathic sudden hearing loss. Otol Neurotol 24(4):572-575
3. Kalkanis JG, Whitworth C, Rybak LP (2004) Vitamin E reduces cisplatin ototoxicity. Laryngoscope 114(3):538-542
4. Ahn JH, Yoo MH, Lee HJ, Chung JW, Yoon TH (2010) Coenzyme Q10 in combination with steroid therapy for treatment of sudden sensorineural hearing loss: a controlled prospective study. Clin Otolaryngol 35(6):486-489
5. Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M (2006) Intravenously administered vitamin C as cancer therapy: three cases. CMAJ 174(7):937-942
6. Wilson WR, Byl FM, Laird N (1980) The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol 106(12):772-776
7. Wei BP, Mubiru S, O'Leary S (2006) Steroids for idiopathic sudden sensorineural hearing loss. Cochrane Database Syst Rev 1:CD003998
8. Tucci DL, Farmer JC Jr, Kitch RD, Witsell DL (2002) Treatment of sudden sensorineural hearing loss with systemic steroids and valacyclovir. Otol Neurotol 23(3):301-308
9. Suckfull M (2002) Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomised multicentre trial. Lancet 360(9348):1811-1817
10. Maetani T, Hakuba N, Taniguchi M, Hyodo J, Shimizu Y, Gyo K (2003) Free radical scavenger protects against inner hair cell loss after cochlear ischemia. NeuroReport 14(14):1881-1884
11. Takemoto T, Sugahara K, Okuda T, Shimogori H, Yamashita H (2004) The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma. Eur J Pharmacol 487(1-3):113-116
12. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M (2004) Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 140(7):533-537
13. Levine M, Wang Y, Padayatty SJ, Morrow J (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci USA 98(17):9842-9846
14. Hemila H, Koivula TT (2008) Vitamin C for preventing and treating tetanus. Cochrane Database Syst Rev 2:CD006665
15. Tsuruta H, Yagishita T, Shimizu M, Tamura H (2011) Megadose vitamin C suppresses sulfoconjugation in human colon carcinoma cell line Caco-2. Toxicol In Vitro 25(2):500-504
16. Padayatty SJ, Levine M (2001) Vitamin C and coronary microcirculation. Circulation 103(23):E117
17. White JD (2002) Complementary and alternative medicine research: a National Cancer Institute perspective. Semin Oncol 29(6):546-551
18. Rivers JM (1989) Safety of high-level vitamin C ingestion. Int J Vitam Nutr Res Suppl 30:95-102
19. Butz M, Hoffmann H, Kohlbecker G (1980) Dietary influence on serum and urinary oxalate in healthy subjects and oxalate stone formers. Urol Int 35(5):309-315
20. Tiselius HG (1980) Oxalate and renal stone formation. Scand J Urol Nephrol Suppl 53:135-148