Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2- (methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran- 3-amine (23)

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 19, 2013, Pages 5361-5366

  Biftu, Tesfaye ^a   Qian, Xiaoxia ^a   Chen, Ping ^a   Feng, Dennis ^a   Scapin, Giovanna ^a   Gao, Ying Duo ^a   Cox, Jason ^a   Sinha Roy, Ranabir ^a   Eiermann, George ^a   He, Huabing ^a   Lyons, Kathy ^a   Salituro, Gino ^a   Patel, Sangita ^a   Petrov, Alexander ^a   Xu, Feng ^a   Xu, Shiyao Sherrie ^a   Zhang, Bei ^a   Caldwell, Charles ^a   Wu, Joseph K ^a   Weber, Ann E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Diabetes; DPP 4 inhibitors; DPP IV; Tetrahydropyran

Indexed keywords

ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; OMARIGLIPTIN; SAXAGLIPTIN; SITAGLIPTIN; TETRAHYDROPYRAN DERIVATIVE; VILDAGLIPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; MAXIMUM PLASMA CONCENTRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PROCESS OPTIMIZATION; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

DIABETES; DPP-4 INHIBITORS; DPP-IV; TETRAHYDROPYRAN;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOGS; ENZYME ACTIVATION; GLUCOSE TOLERANCE TEST; HAPLORHINI; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; INHIBITORY CONCENTRATION 50; PYRANS; RATS; STEREOISOMERISM;

EID: 84883487220     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.07.061     Document Type: Article

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