The BCL2 E17 and SP66 antibodies discriminate 2 immunophenotypically and genetically distinct subgroups of conventionally BCL2-"negative" grade 1/2 follicular lymphomas

Human Pathology

Volumn 44, Issue 9, 2013, Pages 1817-1826

  Adam, Patrick ^a   Baumann, Rosalie ^a   Schmidt, Janine ^a   Bettio, Sabrina ^a   Weisel, Katja ^b   Bonzheim, Irina ^a   Fend, Falko ^a   Quintanilla Martínez, Leticia ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

BCL2 E17 and SP66 antibodies; BCL2 mutations; BCL2 negative follicular lymphoma; t(14; 18) translocation

Indexed keywords

ANTIBODY; BCL2 ANTIBODY; E17 ANTIBODY; EPITOPE; SP66 ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR LYMPHOMA; GENE; GENE LOCUS; HUMAN; IMMUNOPHENOTYPING; MALE; MISSENSE MUTATION; PHENOTYPE; PROTEIN EXPRESSION;

BCL2 E17 AND SP66 ANTIBODIES; BCL2 MUTATIONS; BCL2-NEGATIVE FOLLICULAR LYMPHOMA; T(14;18) TRANSLOCATION;

ADULT; AGED; AGED, 80 AND OVER; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; CLONE CELLS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPH NODES; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; NEOPLASM GRADING; POINT MUTATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSLOCATION, GENETIC;

EID: 84883445861     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.02.004     Document Type: Article

References (21)

1. S.H. Swerdlow, E. Campo, and N.L. Harris WHO Classification of Tumours. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 2008 IARC Press Lyon 220 226
2. E. Leich, I. Salaverria, and S. Bea Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations Blood 114 2009 826 834
3. E. Leich, A. Zamo, and H. Horn MicroRNA profiles of t(14;18)-negative follicular lymphoma support a late germinal center B-cell phenotype Blood 118 2011 5550 5558
4. N. Masir, L.J. Campbell, M. Jones, and D.Y. Mason Pseudonegative BCL2 protein expression in a t(14;18) translocation positive lymphoma cell line: a need for an alternative BCL2 antibody Pathology 42 2010 212 216
5. I. Bonzheim, I. Salaverria, and A. Haake A unique case of follicular lymphoma provides insights to the clonal evolution from follicular lymphoma in situ to manifest follicular lymphoma Blood 118 2011 3442 3444
6. M. Schraders, D. de Jong, P. Kluin, P. Groenen, and H. van Krieken Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation J Pathol 205 2005 329 335
7. P.A. Evans, C. Pott, and P.J. Groenen Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936 Leukemia 21 2007 207 214
8. D. Rykunov, E. Steinberger, C.J. Madrid-Aliste, and A. Fiser Improved scoring function for comparative modeling using the M4T method J Struct Funct Genomics 10 2009 95 99
9. I. Torktaz, Z. Etemadifar, and P. Derikvand Comparative modeling of DszC, an enzyme in biodesulfurization, and performing in silico point mutation for increasing tendency to oil Bioinformation 8 2012 246 250
10. I. Koch, J. Slotta-Huspenina, and R. Hollweck Real-time quantitative RT-PCR shows variable, assay-dependent sensitivity to formalin fixation: implications for direct comparison of transcript levels in paraffin-embedded tissues Diagn Mol Pathol 15 2006 149 156
11. K. Specht, M. Kremer, and U. Muller Identification of cyclin D1 mRNA overexpression in B-cell neoplasias by real-time reverse transcription-PCR of microdissected paraffin sections Clin Cancer Res 8 2002 2902 2911
12. L. Quintanilla-Martinez, S. Pittaluga, and C. Miething NPM-ALK-dependent expression of the transcription factor CCAAT/enhancer binding protein beta in ALK-positive anaplastic large cell lymphoma Blood 108 2006 2029 2036
13. N. Masir, L.J. Campbell, and L.K. Goff BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations Br J Haematol 144 2009 716 725
14. J.G. Lohr, P. Stojanov, and M.S. Lawrence Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing Proc Natl Acad Sci U S A 109 2012 3879 3884
15. J.M. Schuetz, N.A. Johnson, and R.D. Morin BCL2 mutations in diffuse large B-cell lymphoma Leukemia 26 2012 1383 1390
16. X. Deng, F. Gao, T. Flagg, J. Anderson, and W.S. May Bcl2's flexible loop domain regulates p53 binding and survival Mol Cell Biol 26 2006 4421 4434
17. Y. Natkunam, I.S. Lossos, and B. Taidi Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation Blood 105 2005 3979 3986
18. A.J. Arribas, Y. Campos-Martin, and C. Gomez-Abad Nodal marginal zone lymphoma: gene expression and miRNA profiling identify diagnostic markers and potential therapeutic targets Blood 119 2012 e9 e21
19. C. Thorns, K. Kalies, and U. Fischer Significant high expression of CD23 in follicular lymphoma of the inguinal region Histopathology 50 2007 716 719
20. D.E. Horsman, I. Okamoto, and O. Ludkovski Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypes Br J Haematol 120 2003 424 433
21. T. Katzenberger, G. Ott, T. Klein, J. Kalla, H.K. Muller-Hermelink, and M.M. Ott Cytogenetic alterations affecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-cell component Am J Pathol 165 2004 481 490