Misregulation of SDF1-CXCR4 signaling impairs early cardiac neural crest cell migration leading to conotruncal defects

Circulation Research

Volumn 113, Issue 5, 2013, Pages 505-516

  Escot, Sophie ^a,b   Blavet, Cédrine ^a,b   Härtle, Sonja ^c   Duband, Jean Loup ^a,b   Fournier Thibault, Claire ^a,b  

^a Université René Descartes   (France)

^b CNRS   (France)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

cardiac development; cardiac neural crest; conotruncal defects genes; heart defects, congenital; migration; receptors, CXCR4; SDF1 chemokine

Indexed keywords

CHEMOATTRACTANT; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; STROMAL CELL DERIVED FACTOR 1;

ANIMAL EXPERIMENT; ARTICLE; CELL MIGRATION; CHICK EMBRYO; EMBRYO; GENE EXPRESSION; HEART DEATH; HEART MUSCLE CELL; HEART VENTRICLE SEPTUM DEFECT; MOUSE; NEURAL CREST CELL; NONHUMAN; PRIORITY JOURNAL;

CARDIAC DEVELOPMENT; CARDIAC NEURAL CREST; CONOTRUNCAL DEFECTS GENES; HEART DEFECTS, CONGENITAL; MIGRATION; RECEPTORS, CXCR4; SDF1 CHEMOKINE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL MOVEMENT; CHEMOKINE CXCL12; CHEMOTAXIS; CHICK EMBRYO; CHIMERA; COTURNIX; ECTODERM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HEART SEPTAL DEFECTS, VENTRICULAR; MICRORNAS; NEURAL CREST; NEURAL TUBE; ORGAN SPECIFICITY; ORGANOGENESIS; RECEPTORS, CXCR; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TRANSFECTION;

EID: 84883445421     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.301333     Document Type: Article

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