Restoration of the Normal Splicing Pattern of the PLP1 Gene by Means of an Antisense Oligonucleotide Directed against an Exonic Mutation

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Regis, Stefano ^a   Corsolini, Fabio ^a   Grossi, Serena ^a   Tappino, Barbara ^a   Cooper, David N ^b   Filocamo, Mirella ^a  

^a G GASLINI INSTITUTE   (Italy)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CYTIDINE; GUANIDINE;

AMINO ACID SUBSTITUTION; ANTISENSE THERAPY; ARTICLE; COMPUTER MODEL; COMPUTER PREDICTION; CONTROLLED STUDY; DRUG TARGETING; EXON; GENE; GENE CONTROL; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; MISSENSE MUTATION; MUTATIONAL ANALYSIS; OLIGODENDROGLIA; PELIZAEUS MERZBACHER DISEASE; PLP1 GENE; PROTEIN MOTIF; RNA SPLICING; TRANSCRIPTION REGULATION;

EXONS; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; MYELIN PROTEOLIPID PROTEIN; OLIGONUCLEOTIDES, ANTISENSE; PELIZAEUS-MERZBACHER DISEASE; RNA SPLICING; RNA, MESSENGER;

EID: 84883423930     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073633     Document Type: Article

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