Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression

Biochemical Journal

Volumn 454, Issue 3, 2013, Pages 411-416

  Lee, Hee Sook ^a   Kim, Dae Gyu ^a   Oh, Young Sun ^a,b   Kwon, Nam Hoon ^a   Lee, Jin Young ^a   Kim, Doyeun ^a   Park, Song Hwa ^a   Song, Jong Hwan ^c   Lee, Sunkyung ^c   Han, Jung Min ^a   Park, Bum Joon ^d   Lee, Jongkook ^e   Kim, Sunghoon ^a  

^a Seoul National University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

^d Pusan National University   (South Korea)

^e Kangwon National University   (South Korea)

Author keywords

Aminoacyl tRNA synthetase interacting multifunctional protein 2 (AIMP2) DX2; Chemical suppression; Lung cancer; MRNA; Splicing variant

Indexed keywords

ANTINEOPLASTIC AGENT; BC DXI01; MESSENGER RNA; PROTEIN; PROTEIN AIMP2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER REGRESSION; CARCINOGENESIS; CELL DEATH; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; LUNG CANCER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANILIDES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARRIER PROTEINS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PARA-AMINOBENZOATES; PROTEIN ISOFORMS; REMISSION INDUCTION; RNA, MESSENGER; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84883383447     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130550     Document Type: Article

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