Ponatinib (Iclusig) for CML and Ph+ ALL

Medical Letter on Drugs and Therapeutics

Volumn 55, Issue 1424, 2013, Pages 71-72

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

BOSUTINIB; DASATINIB; IMATINIB; NILOTINIB; OMEPRAZOLE; PONATINIB; RIFAMPICIN; ANTINEOPLASTIC AGENT; IMIDAZOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDAZINE DERIVATIVE;

ABDOMINAL PAIN; ACUTE LYMPHOBLASTIC LEUKEMIA; ANEMIA; ARTHRALGIA; CHROMOSOME ANALYSIS; CHRONIC MYELOID LEUKEMIA; CONSTIPATION; DISEASE COURSE; DRUG BIOAVAILABILITY; DRUG TOLERABILITY; DRY SKIN; FATIGUE; FEVER; HEADACHE; HUMAN; HYPERTENSION; HYPERTRANSAMINASEMIA; LETTER; LEUKOPENIA; LYMPHOCYTOPENIA; NAUSEA; NEUTROPENIA; PANCREATITIS; PHASE 3 CLINICAL TRIAL (TOPIC); PHILADELPHIA CHROMOSOME POSITIVE CELL; RASH; SIDE EFFECT; SURVIVAL RATE; THROMBOCYTOPENIA; DRUG INTERACTION; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE;

ANTINEOPLASTIC AGENTS; DRUG INTERACTIONS; HUMANS; IMIDAZOLES; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PROTEIN KINASE INHIBITORS; PYRIDAZINES;

EID: 84883380570     PISSN: 0025732X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (8)

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6. JE Cortes et al. Ponatinib in refractory Philadelphia chromosome-positive leukemias. N Engl J Med 2012; 367:2075.
7. JE Cortes et al. A pivotal phase 2 trial of ponatinib in patients with chronic myeloid leukemia (CML) and Philadelphia chromosomepositive acute lymphoblastic leukemia (Ph+ ALL) resistant or intolerant to dasatinib or nilotinib, or with the T315I BCR-ABL mutation: 12-month follow-up of the PACE trial. Presented at 54th American Society of Hematology Annual Meeting and Exposition. Atlanta, GA; December 8-11, 2012. Abstract No. 163. Available at: https://ash.confex.com/ash/2012/webprogram/paper48561.html. Accessed August 26, 2013.
8. Inhibitors and inducers of CYP enzymes and P-glycoprotein. Med Lett Drugs Ther 2013; 55:e44.