Are Bisphosphonates Effective in the Treatment of Osteoarthritis Pain? A Meta-Analysis and Systematic Review

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Davis, Alison J ^a   Smith, Toby O ^b   Hing, Caroline B ^c   Sofat, Nidhi ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; PLACEBO; RISEDRONIC ACID;

ARTICLE; DRUG EFFICACY; EVIDENCE BASED MEDICINE; FUNCTIONAL ASSESSMENT; HAND OSTEOARTHRITIS; HIP OSTEOARTHRITIS; HUMAN; JOINT STIFFNESS; KNEE OSTEOARTHRITIS; META ANALYSIS; OSTEOARTHRITIS; OSTEOARTHRITIS PAIN; PAIN; PAIN ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); SPONDYLOSIS; SYSTEMATIC REVIEW; TREATMENT OUTCOME; VISUAL ANALOG SCALE; WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX;

BONE DENSITY CONSERVATION AGENTS; DIPHOSPHONATES; HUMANS; OSTEOARTHRITIS; PAIN; TREATMENT OUTCOME;

EID: 84883377215     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072714     Document Type: Article

References (36)

1. Chen A, Gupte C, Akhtar K, Smith P, Cobb J (2012) The Global Economic Cost of Osteoarthritis: How the UK Compares. Arthritis. Article ID: 698709.
2. NICE website (2013) Available: www.nice.org.uk/nicemedia/pdf/CG059FullGuideline.pdf.Accessed 2013 Mar 3.
3. Beswick AD, Wylde V, Gooberman-Hill R, Blom A, Dieppe P, (2012) What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open 22: e000435.
4. Liberman UA, Weiss SR, Bröll J, Minne HW, Quan H, et al. (1995) Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. N Engl J Med 333: 1437-1443.
5. Rodan GA, Fleisch HA, (1996) Bisphosphonates: mechanisms of action. J Clin Invest 97: 2692.
6. Sato M, Grasser W, Endo N, Akins R, Simmons H, et al. (1991) Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 88: 2095.
7. Walsh DA, Chapman V, (2011) Bisphosphonates for osteoarthritis. Arthritis Res Therapy 13(5): 128-129.
8. Buckland-Wright JC, Messent EA, Bingham CO, Ward RJ, Tonkin C, (2007) A 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients. Rheumatology 46: 257-264.
9. Walsh DA, McWilliams DF, Turley MJ, Dixon MR, Franses RE, et al. (2010) Angiogenesis and berve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis. Rheumatology 49: 1852-1861.
10. Yoneda T, Hata K, Nakanishi M, Nagae M, Nagayama T, et al. (2011) Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain. Bone 48: 100-105.
11. Moreau M, Rialland P, Pelletier JP, Martel-Pelletier J, Lajeunesse D, et al. (2011) Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. Arthritis Res Therapy 13: R98.
12. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW, (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15912: 1833-1840.
13. Haugen IK, Slatkowsky-Christensen B, Lessem J, Kvien TJ, (2010) The responsiveness of joint counts, patient-reported measures and proposed composite scores in hand osteoarthritis: analyses from a placebo-controlled trial. Ann Rheum Dis 69: 1436-1440.
14. Moher D, Liberati A, Tetzlaff J, Altmann DG, (2009) The PRISMA group (2009) Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6: e1000097.
15. Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, et al. (1994) Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med 331: 69-73.
16. CASP Critical Appraisal Tool (2012) Available: http://www.sph.nhs.uk/sph-files/casp-appraisal-tools/Qualitative%20appraisal%20tool.pdf/view.Accessed 2012 Jul 24.
17. Smith TO, Walker J, Russell N, (2007) Outcomes of medial patellofemoral ligament reconstruction for patellar instability: a systematic review. Knee Surg Sport Traumatol Arthrosc 15: 1301-1314.
18. Reilly KA, Barker KL, Shamley D, (2006) A systematic review of lateral wedge orthotics- how useful are they in the management of medial compartment osteoarthritis? Knee 13: 177-183.
19. van Tulder M, Furlan A, Bombardier C, Bouter L, (2003) Editorial Board of the Cochrane Collaboration Back Review Group (2003) Updated Method Guidelines for Systematic Reviews in the Cochrane Collaboration Back Review Group. Spine 28: 1290-1299.
20. Lievense AM, Bierma-Zeinstra SM, Verhagen AP, van Baar ME, Verhaar JA, et al. (2002) Influence of obesity on the development of osteoarthritis of the hip: a systematic review. Rheumatology 41: 1155-1162.
21. Yusuf E, Kortekaas MC, Watt I, Huizinga TW, Kloppenburg TW, (2011) Do knee abnormalities visualised on MRI explain pain in knee osteoarthritis? A systematic review. Annals Rheum Dis 70: 60-67.
22. Saviola G, Abdi-Ali L, Campostrini L, Sacco S, Baiardi P, et al. (2012) Clodronate and hydroxychloroquine in erosive osteoarthritis: a 24-month randomized pilot study. Mod Rheumatol 22: 256-263.
23. Bingham CO, Bukland-Wright JC, Gernero P, Bingham CO 3rd, Garnero P, et al. (2006) Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee. Arthritis Rheum 54: 3494-3507.
24. Spector TD, Conaghan PG, Buckland-Wright JC, Gernero P, Cline GA, et al. (2005) Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial. Arthritis Research Therapy 7: R625-33.
25. Carbone LD, Nevitt MC, Wildy K, Barrow KD, Harris F, et al. (2004) Health, Aging and Body Composition Study. The relationship of antiresorptive drug use to structural findings and symptoms of knee osteoarthritis. Arthritis Rheum 50: 3516-3235.
26. Rossini M, Viapiana O, Ramonda R, Biancji G, Olivieri I, et al. (2009) Intra-articular clodronate for the treatment of knee osteoarthritis: dose ranging study vs hyaluronic acid. Rheumatology 48: 773-778.
27. Kawasaki T, Kurosawa H, Ikeda H, Kim SG, Osawa A, et al. (2008) Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18 month trial. J Bone Miner Metab 26: 279-287.
28. Laslett LL, Dore DA, Quinn SJ, Boon P, Ryan E, et al. (2012) Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomized controlled trial. Annal Rheum Dis 71: 1322-1328.
29. Jokar M, Mirfeizi Z, Keyvanpajoh K, (2010) The effect of alendronate on knee symptoms of knee osteoarthritis: a randomized controlled trial. Iran J Med Sci 35: 9-15.
30. Fujita T, Ohue M, Fujii Y, Miyauchi A, Takagi Y, (2008) Analgesic and chondroprotective effects of risedronate in osteoarthritis assessed by electroalgometry and measurement of collagen type II fragments in urine. J Int Med Res 36: 932-941.
31. Fujita T, Fujii Y, Okada SF, Miyauchi A, Takagi Y, (2001) Analgesic effect of etidronate on degenerative joint disease. J Bone Miner Metab 19: 251-256.
32. Fujita T, Ohue M, Fujii Y, Miyauchi A, Takagi Y, (2009) Comparison of the analgesic effects of bisphosphonates: etidronate, alendronate and risedronate by electroalgometry utlisizing the fall of skin impedance. J Bone Miner Metab 27: 234-239.
33. Fujita T, Ohue M, Nakajima M, Fujii Y, Miyauchi A, et al. (2011) Comparison of the effects of elcatonin and risedronate on back and knee pain by electroalgometry using fall of skin impedance and quality of life assessment using SF-36. J Bone Miner Metab 29: 588-597.
34. Nishii T, Tamura S, Shiomi T, Sakai T, Takao M, et al. (2012) Clinical efficacy of alendronate treatment in patients with hip osteoarthritis: a 2-year randomized controlled trial. Osteoarthritis Cartilage 20: S284.
35. Sofat N, Ejindu V, Kiely P, (2011) What makes OA painful? The evidence for peripheral and central pain processing. Rheumatology 50: 2157-2165.
36. Hunter DJ, Guermazi A, Lo GH, Grainger AJ, Conaghan PG, et al. (2011) Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score). Osteoarthritis Cartilage 19: 990-1002.