The Number of Resected Lymph Nodes (nLNs) Combined with Tumor Size as a Prognostic Factor in Patients with Pathologic N0 and Nx Non-Small Cell Lung Cancer

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Yang, Miaomiao ^a,b   Cao, Hongxin ^a   Guo, Xi ^c   Zhang, Tiehong ^a   Hu, Pingping ^a   Du, Jiajun ^a   Liu, Qi ^a  

^a SHANDONG UNIVERSITY   (China)

^b QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE FREE SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LYMPH NODE DISSECTION; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; LUNG NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TUMOR BURDEN; YOUNG ADULT;

EID: 84883369349     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073220     Document Type: Article

References (23)

1. Siegel R, Naishadham D, Jemal A, (2013) Cancer statistics, 2013. CA: A Cancer Journal for Clinicians 63: 11-30.
2. Osarogiagbon RU, (2012) Predicting survival of patients with resectable non-small cell lung cancer: Beyond TNM. Journal of Thoracic Disease 4: 214.
3. Ou S-HI, Zell JA, (2008) Prognostic significance of the number of lymph nodes removed at lobectomy in stage IA non-small cell lung cancer. Journal of Thoracic Oncology 3: 880-886.
4. Wu Y-C, Lin C-FJ, Hsu W-H, Huang B-S, Huang M-H, et al. (2003) Long-term results of pathological stage I non-small cell lung cancer: validation of using the number of totally removed lymph nodes as a staging control. European journal of cardio-thoracic surgery 24: 994-1001.
5. Ludwig MS, Goodman M, Miller DL, Johnstone PA, (2005) Postoperative survival and the number of lymph nodes sampled during resection of node-negative non-small cell lung cancer. CHEST Journal 128: 1545-1550.
6. Xu F, Qi L, Yue D, Wang C (2012) The Effect of the Extent of Lymph Node Dissection for Stage IA Non-Small-Cell Lung Cancer on Patient Disease-Free Survival. Clinical lung cancer.
7. Rusch VW, Hawes D, Decker PA, Martin SE, Abati A, et al. (2011) Occult Metastases in Lymph Nodes Predict Survival in Resectable Non-Small-Cell Lung Cancer: Report of the ACOSOG Z0040 Trial. Journal of Clinical Oncology 29: 4313-4319.
8. Veeramachaneni NK, Battafarano RJ, Meyers BF, Zoole JB, Patterson GA, (2008) Risk factors for occult nodal metastasis in clinical T1N0 lung cancer: a negative impact on survival. European Journal of Cardio-Thoracic Surgery 33: 466-469.
9. Qiu C, Dong W, Su B, Liu Q, Du J, (2013) The Prognostic Value of Ratio-Based Lymph Node Staging in Resected Non-Small-Cell Lung Cancer. Journal of Thoracic Oncology 8: 429-435.
10. Bria E, Milella M, Sperduti I, Alessandrini G, Visca P, et al. (2009) A novel clinical prognostic score incorporating the number of resected lymph-nodes to predict recurrence and survival in non-small-cell lung cancer. Lung Cancer 66: 365-371.
11. Agarwal M, Brahmanday G, Chmielewski GW, Welsh RJ, Ravikrishnan K, (2010) Age, tumor size, type of surgery, and gender predict survival in early stage (stage I and II) non-small cell lung cancer after surgical resection. Lung Cancer 68: 398-402.
12. Xu D, Huang Y, Geng Q, Guan Y, Li Y, et al. (2012) Effect of lymph node number on survival of patients with lymph node-negative gastric cancer according to the 7th edition UICC TNM system. PLoS One 7: e38681.
13. Mersin H, Yi{dotless}ldi{dotless}ri{dotless}m E, Bulut H, Berberoǧlu U, (2003) The prognostic significance of total lymph node number in patients with axillary lymph node-negative breast cancer. European Journal of Surgical Oncology (EJSO) 29: 132-138.
14. Ramirez RA, Wang CG, Miller LE, Adair CA, Berry A, et al. (2012) Incomplete intrapulmonary lymph node retrieval after routine pathologic examination of resected lung cancer. Journal of Clinical Oncology 30: 2823-2828.
15. Varlotto JM, Recht A, Nikolov M, Flickinger JC, DeCamp MM, (2009) Extent of lymphadenectomy and outcome for patients with stage I nonsmall cell lung cancer. Cancer 115: 851-858.
16. Saji H, Tsuboi M, Yoshida K, Kato Y, Nomura M, et al. (2011) Prognostic impact of number of resected and involved lymph nodes at complete resection on survival in non-small cell lung cancer. Journal of Thoracic Oncology 6: 1865-1871.
17. Obiageli Uchenna Ogbata, Xinhua Yu, Raymond U Osarogiagbon. (2012) Prognostic impact of the number of examined lymph nodes (LNs) in resected node negative (pNo) non-small cell lung cancer (NSCLC). 2012 ASCO Annual Meeting.
18. Osarogiagbon RU, Allen JW, Farooq A, Berry A, Spencer D, et al. (2010) Outcome of surgical resection for pathologic N0 and Nx non-small cell lung cancer. Journal of Thoracic Oncology 5: 191-196.
19. Greenstein AJ, Litle VR, Swanson SJ, Divino CM, Packer S, et al. (2008) Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer. Cancer 112: 1239-1246.
20. Johnson PM, Porter GA, Ricciardi R, Baxter NN, (2006) Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer. Journal of clinical oncology 24: 3570-3575.
21. Feinstein AR, Sosin DM, Wells CK, (1985) The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. The New England journal of medicine 312: 1604.
22. Fukui T, Mori S, Yokoi K, Mitsudomi T, (2006) Significance of the number of positive lymph nodes in resected non-small cell lung cancer. Journal of Thoracic Oncology 1: 120-125.
23. Wei S, Asamura H, Kawachi R, Sakurai H, Watanabe S-i, (2011) Which is the better prognostic factor for resected non-small cell lung cancer: the number of metastatic lymph nodes or the currently used nodal stage classification? Journal of Thoracic Oncology 6: 310-318.