Tick-borne encephalitis (TBE) and hepatitis B nonresponders feature different immunologic mechanisms in response to TBE and influenza vaccination with involvement of regulatory T and B cells and IL-10

Journal of Immunology

Volumn 191, Issue 5, 2013, Pages 2427-2436

  Garner Spitzer, Erika ^a   Wagner, Angelika ^a   Paulke Korinek, Maria ^a   Kollaritsch, Herwig ^a   Heinz, Franz X ^b   Redlberger Fritz, Monika ^b   Stiasny, Karin ^b   Fischer, Gottfried F ^b   Kundi, Michael ^b   Wiedermann, Ursula ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN; INFLUENZA VACCINE; INTERLEUKIN 10; TICK BORNE ENCEPHALITIS VACCINE; TRANSCRIPTION FACTOR FOXP3; FSME-IMMUN VACCINE; HEPATITIS B VACCINE; IL10 PROTEIN, HUMAN; VIRUS ANTIBODY; VIRUS VACCINE;

ACTIVE IMMUNIZATION; ADULT; AGED; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMORAL IMMUNITY; IMMUNE RESPONSE; IN VITRO STUDY; INFLUENZA; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TICK BORNE ENCEPHALITIS; BLOOD; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC PREDISPOSITION; GENETICS; HEPATITIS B; IMMUNIZATION; IMMUNOLOGY;

ADULT; ANTIBODIES, VIRAL; B-LYMPHOCYTES, REGULATORY; ENCEPHALITIS, TICK-BORNE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC PREDISPOSITION TO DISEASE; HEPATITIS B; HEPATITIS B VACCINES; HLA-DR ANTIGENS; HUMANS; IMMUNIZATION, SECONDARY; INFLUENZA VACCINES; INTERLEUKIN-10; MALE; T-LYMPHOCYTES, REGULATORY; VIRAL VACCINES;

EID: 84883358946     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1300293     Document Type: Article

References (49)

1. Zuckerman, J. N. 2006. Protective efficacy, immunotherapeutic potential, and safety of hepatitis B vaccines. J. Med. Virol. 78: 169-177.
2. Kubba, A. K., P. Taylor, B. Graneek, and S. Strobel. 2003. Non-responders to hepatitis B vaccination: a review. Commun. Dis. Public Health 6: 106-112.
3. 1988. Immunisation against hepatitis B. Lancet 1: 875-876.
4. Bock, H. L., J. Kruppenbacher, R. Sänger, W. Höbel, R. Clemens, and W. Jilg. 1996. Immunogenicity of a recombinant hepatitis B vaccine in adults. Arch. Intern. Med. 156: 2226-2231.
5. Krämer, A., D. Sommer, E. G. Hahn, and E. O. Riecken. 1986. German experimental hepatitis B vaccine - influence of variation of dosage schedule, sex and age differences on immunogenicity in health care workers. Klin. Wochenschr. 64: 688-694.
6. McDermott, A. B., S. B. Cohen, J. N. Zuckerman, and J. A. Madrigal. 1998. Hepatitis B third-generation vaccines: improved response and conventional vaccine non-response - evidence for genetic basis in humans. J. Viral Hepat. 5 (Suppl. 2): 9-111
7. Jarrosson, L., M. N. Kolopp-Sarda, P. Aguilar, M. C. Béné, M. L. Lepori, M. C. Vignaud, G. C. Faure, and C. Kohler. 2004. Most humoral non-responders to hepatitis B vaccines develop HBV-specific cellular immune responses. Vaccine 22: 3789-3796.
8. Höhler, T., E. Reuss, C. M. Freitag, and P. M. Schneider. 2005. A functional polymorphism in the IL-10 promoter influences the response after vaccination with HBsAg and hepatitis A. Hepatology 42: 72-76.
9. Wiedermann, G., M. Kundi, and F. Ambrosch. 1998. Estimated persistence of anti-HAV antibodies after single dose and booster hepatitis A vaccination (0-6 schedule). Acta Trop. 69: 121-125.
10. Van Herck, K., P. Beutels, P. Van Damme, M. Beutels, J. Van den Dries, P. Briantais, and E. Vidor. 2000. Mathematical models for assessment of longterm persistence of antibodies after vaccination with two inactivated hepatitis A vaccines. J. Med. Virol. 60: 1-7.
11. Rendi-Wagner, P., M. Korinek, B. Winkler, M. Kundi, H. Kollaritsch, and U. Wiedermann. 2007. Persistence of seroprotection 10 years after primary hepatitis A vaccination in an unselected study population. Vaccine 25: 927-931.
12. Garner-Spitzer, E., M. Kundi, P. Rendi-Wagner, B. Winkler, G. Wiedermann, H. Holzmann, C. Herzog, H. Kollaritsch, and U. Wiedermann. 2009. Correlation between humoral and cellular immune responses and the expression of the hepatitis A receptor HAVcr-1 on T cells after hepatitis A re-vaccination in high and low-responder vaccinees. Vaccine 27: 197-204.
13. Kunz, C. 2003. TBE vaccination and the Austrian experience. Vaccine 21(Suppl. 1): S50-S55.
14. Kaiser, R., and H. Holzmann. 2000. Laboratory findings in tick-borne encephalitis - correlation with clinical outcome. Infection 28: 78-84.
15. Rendi-Wagner, P., M. Kundi, O. Zent, A. Banzhoff, P. Jaehnig, R. Stemberger, G. Dvorak, E. Grumbeck, B. Laaber, and H. Kollaritsch. 2004. Immunogenicity and safety of a booster vaccination against tick-borne encephalitis more than 3 years following the last immunisation. Vaccine 23: 427-434.
16. Rendi-Wagner, P., M. Paulke-Korinek, M. Kundi, U. Wiedermann, B. Laaber, and H. Kollaritsch. 2007. Antibody persistence following booster vaccination against tick-borne encephalitis: 3-year post-booster follow-up. Vaccine 25: 5097-5101.
17. Stiasny, K., S. Kiermayr, H. Holzmann, and F. X. Heinz. 2006. Cryptic properties of a cluster of dominant flavivirus cross-reactive antigenic sites. J. Virol. 80: 9557-9568.
18. Holzmann, H., M. Kundi, K. Stiasny, J. Clement, P. McKenna, C. Kunz, and F. X. Heinz. 1996. Correlation between ELISA, hemagglutination inhibition, and neutralization tests after vaccination against tick-borne encephalitis. J. Med. Virol. 48: 102-107.
19. Fiore, A. E., D. K. Shay, K. Broder, J. K. Iskander, T. M. Uyeki, G. Mootrey, J. S. Bresee, and N. J. Cox. 2009. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009. MMWR Recomm. Rep. 58: 1-52.
20. WHO. 2011. Manual for the diagnosis and virological surveillance of Influenza. Available at: http://whqlibdoc.who.int/publications/2011/ 9789241548090-eng.pdff
21. Ludajic, K., Y. Balavarca, H. Bickebö ller, D. Pohlreich, M. Kouba, M. Dobrovolna, M. Vrana, A. Rosenmayr, G. F. Fischer, I. Fae, et al. 2008. Impact of HLA-DPB1 allelic and single amino acid mismatches on HSCT. Br. J. Haematol. 142: 436-443.
22. Gassmann, C., and G. Bauer. 1997. Avidity determination of IgG directed against tick-borne encephalitis virus improves detection of current infections. J. Med. Virol. 51: 242-251.
23. Woodland, D. L., and J. E. Kohlmeier. 2009. Migration, maintenance and recall of memory T cells in peripheral tissues. Nat. Rev. Immunol. 9: 153-161.
24. Monteiro, M., C. Evaristo, A. Legrand, A. Nicoletti, and B. Rocha. 2007. Cartography of gene expression in CD8 single cells: novel CCR72 subsets suggest differentiation independent of CD45RA expression. Blood 109: 2863-2870.
25. Appay, V., P. R. Dunbar, M. Callan, P. Klenerman, G. M. Gillespie, L. Papagno, G. S. Ogg, A. King, F. Lechner, C. A. Spina, et al. 2002. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8: 379-385.
26. Grossman, W. J., J. W. Verbsky, B. L. Tollefsen, C. Kemper, J. P. Atkinson, and T. J. Ley. 2004. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104: 2840-2848.
27. Blair, P. A., L. Y. Noreña, F. Flores-Borja, D. J. Rawlings, D. A. Isenberg, M. R. Ehrenstein, and C. Mauri. 2010. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 32: 129-140.
28. Aberle, J. H., K. Stiasny, M. Kundi, and F. X. Heinz. 2013. Mechanistic insights into the impairment of memory B cells and antibody production in the elderly. Age 35: 371-381.
29. Litjens, N. H., M. Huisman, D. Hijdra, B. M. Lambrecht, K. J. Stittelaar, and M. G. Betjes. 2008. IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells. J. Immunol. 181: 3665-3673.
30. Berod, L., F. Puttur, J. Huehn, and T. Sparwasser. 2012. Tregs in infection and vaccinology: heroes or traitors? Microb. Biotechnol. 5: 260-269.
31. Surls, J., C. Nazarov-Stoica, M. Kehl, S. Casares, and T. D. Brumeanu. 2010. Differential effect of CD4+Foxp3+ T-regulatory cells on the B and T helper cell responses to influenza virus vaccination. Vaccine 28: 7319-7330.
32. Hippen, K. L., J. L. Riley, C. H. June, and B. R. Blazar. 2011. Clinical perspectives for regulatory T cells in transplantation tolerance. Semin. Immunol. 23: 462-468.
33. Campbell, D. J., and M. A. Koch. 2011. Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat. Rev. Immunol. 11: 119-130.
34. Wiedermann, U., C. Wiltschke, J. Jasinska, M. Kundi, R. Zurbriggen, E. Garner-Spitzer, R. Bartsch, G. Steger, H. Pehamberger, O. Scheiner, and C. C. Zielinski. 2010. A virosomal formulated Her-2/neu multi-peptide vaccine induces Her-2/neu-specific immune responses in patients with metastatic breast cancer: a phase I study. Breast Cancer Res. Treat. 119: 673-683.
35. Vergati, M., V. Cereda, R. A. Madan, J. L. Gulley, N. Y. Huen, C. J. Rogers, K. W. Hance, P. M. Arlen, J. Schlom, and K. Y. Tsang. 2011. Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination. Cancer Immunol. Immunother. 60: 197-206.
36. Roncarolo, M. G., S. Gregori, M. Battaglia, R. Bacchetta, K. Fleischhauer, and M. K. Levings. 2006. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev. 212: 28-50.
37. Litjens, N. H., K. Boer, and M. G. Betjes. 2012. Identification of circulating human antigen-reactive CD4+ FOXP3+ natural regulatory T cells. J. Immunol. 188: 1083-1090.
38. Yang, Z., L. Wang, W. Niu, Y. Wu, J. Zhang, and G. Meng. 2008. Increased CD4+CD25+FoxP3+ regulatory T cells in the blood of nonresponders after standard hepatitis B surface antigen vaccine immunization. Clin. Immunol. 127: 265-266.
39. Yang, Z., S. Wang, J. Zhang, L. Wang, and Y. Wu. 2008. Expression of PD-1 is up-regulated in CD4+CD25+ FoxP3+ regulatory T cell of non-responders after hepatitis B surface antigen vaccine immunization. Clin. Immunol. 129: 176-177.
40. Li, J., D. Tan, H. Liu, and K. Li. 2011. CD4(+) CD25(+) FoxP3(+) T regulatory cells in subjects responsive or unresponsive to hepatitis B vaccination. Zhong Nan Da Xue Xue Bao Yi Xue Ban 36: 1046-1051.
41. Duddy, M., M. Niino, F. Adatia, S. Hebert, M. Freedman, H. Atkins, H. J. Kim, and A. Bar-Or. 2007. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J. Immunol. 178: 6092-6099.
42. Correale, J., M. Farez, and G. Razzitte. 2008. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann. Neurol. 64: 187-199.
43. Anolik, J. H., J. Barnard, T. Owen, B. Zheng, S. Kemshetti, R. J. Looney, and I. Sanz. 2007. Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy. Arthritis Rheum. 56: 3044-3056.
44. Newell, K. A., A. Asare, A. D. Kirk, T. D. Gisler, K. Bourcier, M. Suthanthiran, W. J. Burlingham, W. H. Marks, I. Sanz, R. I. Lechler, et al; Immune Tolerance Network ST507 Study Group. 2010. Identification of a B cell signature associated with renal transplant tolerance in humans. J. Clin. Invest. 120: 1836-1847.
45. Das, A., G. Ellis, C. Pallant, A. R. Lopes, P. Khanna, D. Peppa, A. Chen, P. Blair, G. Dusheiko, U. Gill, et al. 2012. IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection. J. Immunol. 189: 3925-3935.
46. Lemoine, S., A. Morva, P. Youinou, and C. Jamin. 2011. Human T cells induce their own regulation through activation of B cells. J. Autoimmun. 36: 228-238.
47. Lanzavecchia, A., and F. Sallusto. 2005. Understanding the generation and function of memory T cell subsets. Curr. Opin. Immunol. 17: 326-332.
48. Amanna, I. J., and M. K. Slifka. 2011. Contributions of humoral and cellular immunity to vaccine-induced protection in humans. Virology 411: 206-215.
49. Segura, E., and J. A. Villadangos. 2011. A modular and combinatorial view of the antigen cross-presentation pathway in dendritic cells. Traffic 12: 1677-1685.