TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspasemediated NDUFS1 cleavage and ROS formation

Journal of Cell Science

Volumn 126, Issue 17, 2013, Pages 4015-4025

  Huai, Jisen ^a,b   Vogtle, F Nora ^a   Jocke, Lars ^a   Li, Yunbo ^b   Kiefer, Thomas ^a   Ricci, Jean Ehrland ^c,d,e   Borner, Christoph ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c UNIVERSITY HOSPITAL OF NICE   (France)

^d CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^e UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

Apoptosis; Apoptosome; Bak; Bax; Caspase; LMP; MitoQ; MOMP; ROS; TNF

Indexed keywords

ANTIOXIDANT; APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 7; CASPASE 9; CATHEPSIN B; CATHEPSIN D; CATHEPSIN L; CYCLOHEXIMIDE; CYTOCHROME C; ETOPOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOCHONDRIAL PROTEIN; MUTANT PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN P75; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; TUMOR NECROSIS FACTOR ALPHA; TUNICAMYCIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIVISION; CELL FRACTIONATION; CELL MEMBRANE PERMEABILITY; CELL PERMEABILIZATION; CELL RESPIRATION; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME SUBUNIT; FEEDBACK SYSTEM; FLUORESCENCE ACTIVATED CELL SORTING; GENE AMPLIFICATION; HELA CELL; LYSOSOME MEMBRANE; MAMMAL CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; OUTER MEMBRANE PERMEABILIZATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SUBUNIT; PROTEIN SYNTHESIS; RESPIRATORY CHAIN; WILD TYPE;

APOPTOSIS; APOPTOSOME; BAK; BAX; CASPASE; LMP; MITOQ; MOMP; ROS; TNFΑ;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 7; CASPASE 9; CATHEPSIN B; CATHEPSIN L; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CYCLOHEXIMIDE; ELECTRON TRANSPORT COMPLEX I; ENZYME ACTIVATION; HELA CELLS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; NADH DEHYDROGENASE; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN SYNTHESIS INHIBITORS; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA; UBIQUINONE;

EID: 84883307364     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.129999     Document Type: Article

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