Mathematical modeling of intravascular drug delivery in drug-eluting stents with biodegradable coating

Computing and Systems Technology Division - Core Programming Topic at the 2011 AIChE Annual Meeting

Volumn 2, Issue , 2011, Pages 860-861

  Zhu, Xiaoxiang ^a   Braatz, Richard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84883296480     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (6)

1. G. Acharya, K. Park, Mechanisms of controlled drug release from drug-eluting stents, Adv Drug Deliver Rev, 58 (2006) 387-401.
2. A. Finkelstein, D. McClean, S. Kar, K. Takizawa, K. Varghese, N. Baek, K. Park, M.C. Fishbein, R. Makkar, F. Litvack, N.L. Eigler, Local drug delivery via a coronary stent with programmable release pharmacokinetics, Circulation, 107 (2003) 777-784.
3. R.P. Batycky, J. Hanes, R. Langer, D.A. Edwards, A theoretical model of erosion and macromolecular drug release from biodegrading microspheres, Journal of Pharmaceutical Sciences, 86 (1997) 1464-1477.
4. X.T. Wang, S.S. Venkatraman, F.Y.C. Boey, J.S.C. Loo, L.P. Tan, Controlled release of sirolimus from a multilayered PLGA stent matrix, Biomaterials, 27 (2006) 5588-5595.
5. X. Zhu, D.W. Pack, R.D. Braatz, Modeling intravascular delivery from drug-eluting stents: effect of anisotropic vascular diffusivity and drug loading on arterial drug distribution (submitted).
6. M.A. Lovick, E.R. Edelman, Computational simulations of local vascular heparin deposition and distribution, Am J Physiol-Heart C, 40 (1996) H2014-H2024.