Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with type 2 diabetes: Interim outcomes from the GREAT2DO trial

Diabetes Care

Volumn 36, Issue 8, 2013, Pages 2372-2379

  Mavros, Yorgi ^a   Kay, Shelley ^a   Anderberg, Kylie A ^a   Baker, Michael K ^a,b,i   Wang, Yi ^a,c   Zhao, Renru ^a   Meiklejohn, Jacinda ^a   Climstein, Mike ^e   O'Sullivan, Anthony ^f   De Vos, Nathan ^a,d   Baune, Bernhard T ^g   Blair, Steven N ^h   Simar, David ^f   Rooney, Kieron ^a   Singh, Nalin ^a,d   Singh, Maria A Fiatarone ^a,i,j,k  

^a UNIVERSITY OF SYDNEY   (Australia)

^b AUSTRALIAN CATHOLIC UNIVERSITY   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Balmain Hospital   (Australia)

^e BOND UNIVERSITY   (Australia)

^f UNIVERSITY OF NEW SOUTH WALES   (Australia)

^g UNIVERSITY OF ADELAIDE   (Australia)

^h UNIVERSITY OF SOUTH CAROLINA   (United States)

ⁱ UNIVERSITY OF SYDNEY   (Australia)

^j HARVARD MEDICAL SCHOOL   (United States)

^k TUFTS UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

ADULT; ARTICLE; BODY COMPOSITION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EXERCISE INTENSITY; FAT MASS; GLUCOSE HOMEOSTASIS; HEALTH STATUS; HEMOGLOBIN BLOOD LEVEL; HIGH INTENSITY PROGRESSIVE RESISTANCE TRAINING; HUMAN; INSULIN RESISTANCE; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MUSCLE FUNCTION; MUSCLE MASS; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL PARAMETERS; RANDOMIZED CONTROLLED TRIAL; BIOLOGICAL MODEL; DIABETES MELLITUS, TYPE 2; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; METABOLISM; PHYSIOLOGY; RESISTANCE TRAINING;

BLOOD GLUCOSE; BODY COMPOSITION; DIABETES MELLITUS, TYPE 2; HEMOGLOBIN A, GLYCOSYLATED; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; MODELS, BIOLOGICAL; RESISTANCE TRAINING;

EID: 84883291926     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-2196     Document Type: Article

References (29)

1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87:4-14
2. Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME, Castaneda-Sceppa C. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Int J Med Sci 2007;4:19-27
3. Castaneda C, Layne JE, Munoz-Orians L, et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 2002;25:2335-2341
4. Dunstan DW, Daly RM, Owen N, et al. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care 2002; 25:1729-1736
5. Cuff DJ, MeneillyGS,MartinA, Ignaszewski A, Tildesley HD, Frohlich JJ. Effective exercise modality to reduce insulin resistance in women with type 2 diabetes. Diabetes Care 2003;26:2977-2982
6. Baldi JC, Snowling N. Resistance training improves glycaemic control in obese type 2 diabetic men. Int J Sports Med 2003;24: 419-423
7. Posters: T5-Clinical Practice and Multi Disciplinary Management. Obesity Facts 2012;5(Suppl 1):178-234
8. Janssen I, Heymsfield SB, Baumgartner RN, Ross R. Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol 2000;89:465-471
9. Lukaski HC, Bolonchuk WW, Hall CB, Siders WA. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol 1986;60:1327-1332
10. Sinn DH, Gwak GY, Park HN, et al. Ultrasonographically detected non-alcoholic fatty liver disease is an independent predictor for identifying patients with insulin resistance in non-obese, non-diabetic middleaged Asian adults. AmJ Gastroenterol 2012; 107:561-567
11. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004;27:1487-1495
12. Faul F, Erdfelder E, Lang AG, Buchner AG. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007;39:175-191
13. BouléNG,Haddad E, KennyGP,WellsGA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 2001;286:1218-1227
14. Stratton IM, Adler AI, Neil HAW, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ 2000;321: 405-412
15. Gallwitz B, Rosenstock J, Rauch T, et al. 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, noninferiority trial. Lancet 2012;380:475-483
16. Emoto M, Nishizawa Y, Maekawa K, et al. Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care 1999;22:818-822
17. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000;23:57-63
18. Levitzky YS, Pencina MJ, D'Agostino RB, et al. Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study. J AmColl Cardiol 2008; 51:264-270
19. Petersen KF, Dufour S, Savage DB, et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci USA 2007;104:12587-12594
20. Rabøl R, Petersen KF, Dufour S, Flannery C, Shulman GI. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc Natl Acad Sci USA 2011;108:13705-13709
21. Straczkowski M, Kowalska I. The role of skeletal muscle sphingolipids in the development of insulin resistance. Rev Diabet Stud 2008;5:13-24
22. Corcoran MP, Lamon-Fava S, Fielding RA. Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise. Am J Clin Nutr 2007; 85:662-677
23. Perseghin G. Muscle lipid metabolism in the metabolic syndrome. Curr Opin Lipidol 2005;16:416-420
24. Tarnopolsky MA. Mitochondrial DNA shifting in older adults following resistance exercise training. Appl Physiol Nutr Metab 2009;34:348-354
25. Perseghin G. Lipids in the wrong place: visceral fat and nonalcoholic steatohepatitis. Diabetes Care 2011;34(Suppl 2): S367-S370
26. Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006;17:4-12
27. Preis SR, Massaro JM, Robins SJ, et al. Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study. Obesity (Silver Spring) 2010;18:2191-2198
28. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 2002;106:2085-2090
29. Miyachi M. Effects of resistance training on arterial stiffness: a meta-analysis. Br J Sports Med 2013;47:393-396