Human papilloma virus 16 e6 protein as a target for curcuminoids, curcumin conjugates and congeners for chemoprevention of oral and cervical cancers

Interdisciplinary Sciences – Computational Life Sciences

Volumn 5, Issue 2, 2013, Pages 112-118

  Singh, Ajay Kr ^a   Misra, Krishna ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

chlorogenic acid; congeners; curcumin piperoyl conjugate; curcuminoids; docking; HPV 16 E6 protein; human papilloma virus; oral cervical cancers

Indexed keywords

CURCUMA; CURCUMA LONGA; HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 16;

CHLOROGENIC ACID; CURCUMIN; DRUG DERIVATIVE; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; LIGAND; ONCOPROTEIN; REPRESSOR PROTEIN;

ARTICLE; CHEMISTRY; CHEMOPROPHYLAXIS; DRUG EFFECT; ENZYME ACTIVE SITE; FEMALE; HUMAN; HYDROGEN BOND; METABOLISM; MOLECULAR DOCKING; MOUTH TUMOR; THERMODYNAMICS; UTERINE CERVIX TUMOR; VIROLOGY;

CATALYTIC DOMAIN; CHEMOPREVENTION; CHLOROGENIC ACID; CURCUMIN; FEMALE; HUMANS; HYDROGEN BONDING; LIGANDS; MOLECULAR DOCKING SIMULATION; MOUTH NEOPLASMS; ONCOGENE PROTEINS, VIRAL; REPRESSOR PROTEINS; THERMODYNAMICS; UTERINE CERVICAL NEOPLASMS;

EID: 84883286573     PISSN: 19132751     EISSN: 18671462     Source Type: Journal    
DOI: 10.1007/s12539-013-0159-8     Document Type: Article

References (24)

1. Anand, P., Thomas, S. G., Kumar, A., Kunnumakkaram, B., Sundaram, C., Misra, K., Priyadarsini, I. K., Rajasekharan, N. K., Aggarwal, B. B. 2008. Antioxidant, anti-inflammatory, anticancer, anticarcinogenic, antidiabetic and neuroprotective effects of curcuminanalogues (congeners) made by man and mother nature (review). Biochemical Pharmocolgy 76, 1590-1611.
2. Baleja, J. D., Cherry, J. J., Zhiguo, L., Gaob, H., Nicklaus, M. C., Johannes, H. V., Jason, J. C., Elliot, J. A. 2006. Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins. Antiviral Res 72, 49-59.
3. Campisi, G., Giovannelli. L. 2009. Controversies surrounding human papilloma virus infection, head & neck vs. oral cancer, implications for prophylaxis and treatment. Head Neck Oncol 1, 1-8.
4. Chakravarti, N., Jeffrey, N., Myers, N., Aggarwal, B. B. 2006. Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane). Int J Cancer 119, 1268-1275.
5. Clifford, G. M., Smith, J. S., Plummer, M., Munoz, N., Franceschi, S. 2003. Human papillomavirus types in invasive cancer worldwide: A meta-analysis. Br J Cancer 88, 63-73.
6. Degenkolbe, R., Gilligan, P., Gupta, S., Bernard, H. U. 2003. Chelating agents stabilize the monomeric state of the zinc binding human papillomavirus 16 e6 oncoprotein. Biochemistry 42, 3868-3873.
7. Doorbar, J. 2006. Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci 110, 525-541.
8. Füllbeck, M., Huang, X., Dumdey, R., Fromme, C., Dubiel, W., Preissner, R. 2005. Novel curcuminand emodin-related compounds identified by in silico 2D/3Dconformer screening induce apoptosis in tumor cells. BMC Cancer 5, 97.
9. Glusker, J. P. 1998. Directional aspects of intermolecular interactions. In: Weber, E. (Ed.) Topics in Current Chemistry Design of Organic Solids, Springer-Verlag, Berlin and Heidelberg, 1-56.
10. Kapoor, N., Sharma, A., Dwivedi, V., Kumar, A., Pati, U., Misra, K. 2006. Telomerase targeted anticancer bioactive prodrug by antisense based approach. Cancer Lett 248, 245-250.
11. Lin, L., Shi, Q., Nyarko, A. K., Bastow, K. F., Wu, C. C., Su, C. Y., Shih, C. C., Lee, K. H. 2006. Design and synthesis of new curcumin analogues as potential antiprostate cancer agents. J Med Chem 13, 3963-3972.
12. Mantovani, F., Banks, L. 2001. The human papillomavirus E6 protein and its contribution to malignant progression. Oncogene 20, 7874-7887.
13. Mishra, S., Kapoor, N., Mubarak, A., Pardharasaradhi, B. V. V., Kumari, L., Khar, A., Misra, K. 2005a. Differential apoptotic and redox regulatory activities of curcumin and its derivatives. Free Radic Biol Med 38, 1353-1360.
14. Mishra, S., Narain, U., Mishra, R., Misra, K. 2005b. Design development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin-glycine-piperic acid and their antibacterial and antifungal properties. Bioorg Medicinal Chem 13, 1477-1486.
15. Nomine, Y., Charbonnier, S., Ristriani, T., Stier, G., Masson, M., Cavusoglu, N., Dorsselaer, A. V., Weiss, E., Kieffer, B., Trave, G. 2003. Domain substructure of HPV E6 oncoprotein: Biophysical characterization of the E6 C-terminal DNA-binding domain. Biochemistry 42, 4909-4917.
16. Nomine, Y. S., Charbonnier, L., Miguet, N., Potier, A. V., Dorsselaer, R. A., Atkinson, G. T, Kieffer, B. 2005. (1) H and (15) N resonance assignment, secondary structure and dynamic behaviour of the Cterminal domain of human papillomavirus oncoprotein E6. J Biomol NMR 31, 129-141.
17. Nomine, Y. M., Masson, S., Charbonnier, Z. K., Ristriani, T., Deryckere, F., Sibler, A. P., Desplancq, D., Atkinson, R. A., Weiss, E., Orfanoudakis, G., Kieffer, B., Trave, G. 2006. Structural and functional analysis of e6 oncoprotein: Insights in the molecular pathways of human papillomavirus-mediated pathogenesis. Mol Cell 21, 665-678.
18. Ohtsu, H., Xiao, Z., Ishida, J., Nagai, M., Wang, H. K., Itokawa, H., Su, C. Y., Shih, C., Chiang, T., Chang, E., Lee, Y., Tsai, M. Y., Chang, C., Lee, K. H. 2002. Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as antiprostate cancer agents. J Med Chem 23, 5037-5042.
19. Peng, S., Ji, H., Trimble, C., He, L., Tsai, Y. C., Yeatermeyer, J., Boyd, D. A. K., Hung, C. F., Wu, T. C. 2004. Development of a DNA vaccine targeting human papillomavirus type 16 oncoprotein E6. J Virol 78, 8468-8476.
20. Ravindran, J., Prasad, P., Aggarwal, B. B. 2009. Curcumin and cancer cells: How many ways can curry kill tumor cells selectively? AAPS J 11, 495-510.
21. Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., Srinivas, P. S. S. R. 1998. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64, 353-356.
22. Singh, N. 2005. HPV and cervical cancer-prospects for prevention through vaccination. Indian JMed Paediatr Oncol 26, 20-23.
23. Ullman, C. G., Haris, P. I., Galloway, D. A., Emery, V. C., Perkins, S. J. 1996. Predicted α-helix/β-sheet secondary structures for the zinc-binding motifs of human papillomavirus E7 and E6 proteins by consensus prediction averaging and spectroscopic studies of E7. Biochem J 319, 229-239.
24. st century: The impact of HPV on the epidemiology and pathology of oral cancer. Head and Neck Pathol 3, 78-81.