Beam angle selection for intensity-modulated radiotherapy (IMRT) treatment of unresectable pancreatic cancer: Are noncoplanar beam angles necessary?

Clinical and Translational Oncology

Volumn 15, Issue 9, 2013, Pages 720-724

  Chang, D S ^a   Bartlett, G K ^a   Das, I J ^a   Cardenes, H R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dosimetric comparison; IMRT; Noncoplanar fields; Pancreatic cancer; Treatment technique

Indexed keywords

GEMCITABINE;

ARTICLE; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CLINICAL ARTICLE; COMPUTER ASSISTED RADIOTHERAPY; CONTROLLED STUDY; COPLANAR BEAM ANGLE; DOSIMETRY; DUODENUM; HUMAN; INTENSITY MODULATED RADIATION THERAPY; INTERMETHOD COMPARISON; KIDNEY; LIVER; NONCOPLANAR BEAM ANGLE; ORGANS AT RISK; PANCREAS ADENOCARCINOMA; RADIATION BEAM; RADIATION DOSE DISTRIBUTION; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOLOGICAL PARAMETERS; RISK FACTOR; SMALL INTESTINE; SPINAL CORD; STOMACH; THREE DIMENSIONAL CONFORMAL RADIOTHERAPY; TREATMENT PLANNING;

ADENOCARCINOMA; ALGORITHMS; HUMANS; KIDNEY; ORGANS AT RISK; PANCREATIC NEOPLASMS; RADIOMETRY; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, INTENSITY-MODULATED; RISK FACTORS;

EID: 84883282013     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-012-0998-5     Document Type: Article

References (20)

1. Huguet F, Andre T, Hammel P, Artru P, Balosso J, Selle F et al (2007) Impact of chemoradiotherapy after disease control with chemotherapy in locally advanced pancreatic adenocarcinoma in GERCOR phase II and III studies. J Clin Oncol 25(3):326-331
2. Loehrer PJ Sr, Feng Y, Cardenes H, Wagner L, Brell JM, Cella D et al (2011) Gemcitabine alone versus gemcitabine plus radiotherapy in patients with locally advanced pancreatic cancer: an Eastern Cooperative Oncology Group trial. J Clin Oncol 29(31):4105-4112
3. Moertel CG, Frytak S, Hahn RG, O'Connell MJ, Reitemeier RJ, Rubin J et al (1981) Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group. Cancer 48(8):1705-1710
4. Blackstock AW, Mornex F, Partensky C, Descos L, Case LD, Melin SA et al (2006) Adjuvant gemcitabine and concurrent radiation for patients with resected pancreatic cancer: a phase II study. Br J Cancer 95(3):260-265
5. Cardenes HR, Moore AM, Johnson CS, Yu M, Helft P, Chiorean EG et al (2011) A phase II study of gemcitabine in combination with radiation therapy in patients with localized, unresectable, pancreatic cancer: a Hoosier Oncology Group study. Am J Clin Oncol 34(5):460-465
6. Kalser MH, Ellenberg SS (1985) Pancreatic cancer. Adjuvant combined radiation and chemotherapy following curative resection. Arch Surg 120(8):899-903
7. Klinkenbijl JH, Jeekel J, Sahmoud T, van Pel R, Couvreur ML, Veenhof CH et al (1999) Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 230(6):776-782 discussion 82-4
8. Regine WF, Winter KA, Abrams R, Safran H, Hoffman JP, Konski A et al (2011) Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U.S. Intergroup/RTOG 9704 phase III trial. Ann Surg Oncol 18(5):1319-1326
9. Van Laethem JL, Hammel P, Mornex F, Azria D, Van Tienhoven G, Vergauwe P et al (2010) Adjuvant gemcitabine alone versus gemcitabine-based chemoradiotherapy after curative resection for pancreatic cancer: a randomized EORTC-40013-22012/FFCD-9203/GERCOR phase II study. J Clin Oncol 28(29):4450-4456
10. Chu JC, Solin LJ, Hwang CC, Kessler H, Hanks GE (1992) Three-dimensional dosimetric comparison of radiation therapy treatment planning of the pancreas. Med Dosim 17(4):199-203
11. Gearheart DM, Walker P, Collett BS, Modur RS (2007) An improved approach to external beam radiation therapy for intra-abdominal cavity lesions for rural cancer centers. Med Dosim 32(4):271-277
12. Higgins PD, Sohn JW, Fine RM, Schell MC (1995) Three-dimensional conformal pancreas treatment: comparison of four- to six-field techniques. Int J Radiat Oncol Biol Phys 31(3):605-609
13. Osborne C, Bydder SA, Ebert MA, Spry NA (2006) Comparison of non-coplanar and coplanar irradiation techniques to treat cancer of the pancreas. Australas Radiol 50(5):463-467
14. Sebestyen Z, Kovacs P, Gulyban A, Farkas R, Bellyei S, Liposits G et al (2011) Conkiss: conformal kidneys sparing 3D noncoplanar radiotherapy treatment for pancreatic cancer as an alternative to IMRT. Med Dosim 36(1):35-40
15. Milano MT, Chmura SJ, Garofalo MC, Rash C, Roeske JC, Connell PP et al (2004) Intensity-modulated radiotherapy in treatment of pancreatic and bile duct malignancies: toxicity and clinical outcome. Int J Radiat Oncol Biol Phys 59(2):445-453
16. Landry JC, Yang GY, Ting JY, Staley CA, Torres W, Esiashvili N et al (2002) Treatment of pancreatic cancer tumors with intensity-modulated radiation therapy (IMRT) using the volume at risk approach (VARA): employing dose-volume histogram (DVH) and normal tissue complication probability (NTCP) to evaluate small bowel toxicity. Med Dosim 27(2):121-129
17. Abelson JA, Murphy JD, Minn AY, Chung M, Fisher GA, Ford JM, et al (2011) Intensity-modulated radiotherapy for pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys. Epub 2011/12/27
18. Ben-Josef E, Shields AF, Vaishampayan U, Vaitkevicius V, El-Rayes BF, McDermott P et al (2004) Intensity-modulated radiotherapy (IMRT) and concurrent capecitabine for pancreatic cancer. Int J Radiat Oncol Biol Phys 59(2):454-459
19. Yovino S, Poppe M, Jabbour S, David V, Garofalo M, Pandya N et al (2011) Intensity-modulated radiation therapy significantly improves acute gastrointestinal toxicity in pancreatic and ampullary cancers. Int J Radiat Oncol Biol Phys 79(1):158-162
20. Srivastava SP, Das IJ, Kumar A, Johnstone PAS (2011) Dosimetric comparison of manual and beam angle optimization of gantry angles in IMRT. Med Dosim 36(3):313-316