Catheter-related thrombosis in cancer patients

British Journal of Haematology

Volumn 162, Issue 6, 2013, Pages 748-757

  Murray, Jim ^a   Precious, Elizabeth ^a   Alikhan, Raza ^a  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

Anticoagulation; Cancer; Central venous catheter; Venous thrombosis

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; DALTEPARIN; ENOXAPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; POLYETHYLENE; POLYURETHAN; UROKINASE; WARFARIN;

CANCER PATIENT; CATHETER INFECTION; CATHETER REMOVAL; CATHETER THROMBOSIS; CENTRAL VENOUS CATHETER; CENTRAL VENOUS CATHETERIZATION; COMPUTER ASSISTED TOMOGRAPHY; DRUG EFFICACY; DRUG HALF LIFE; DRUG RESPONSE; DRUG SAFETY; HEMATOLOGIC MALIGNANCY; HUMAN; INCIDENCE; INFECTION; JUGULAR VEIN; LOW DRUG DOSE; LUNG EMBOLISM; MATERIAL COATING; MATERIAL STATE; MEDICAL HISTORY; NEOPLASM; PHLEBOGRAPHY; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; SUBCLAVIAN VEIN; THROMBOPHILIA; VASCULAR ACCESS; VEIN THROMBOSIS; VENOUS THROMBOEMBOLISM; X RAY;

ANTICOAGULATION; CANCER; CENTRAL VENOUS CATHETER; VENOUS THROMBOSIS;

CATHETERIZATION, CENTRAL VENOUS; CENTRAL VENOUS CATHETERS; HUMANS; NEOPLASMS; THROMBOSIS;

EID: 84883270177     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12474     Document Type: Review

References (84)

1. Abdelkefi, A., Ben Othman, T., Kammoun, L., Chelli, M., Romdhane, N.B., Kriaa, A., Ladeb, S., Torjman, L., Lakhal, A., Achour, W., Ben Hassen, A., Hsaïri, M., Ladeb, F. & Ben Abdeladhim, A. (2004) Prevention of central venous line-related thrombosis by continuous infusion of low-dose unfractionated heparin, in patients with haemato-oncological disease. Thrombosis and Haemostasis, 92, 654-661.
2. Akl, E.A., Vasireddi, S.R., Gunukula, S., Yosuico, V.E., Barba, M., Sperati, F., Cook, D. & Schünemann, H. (2011) Anticoagulation for patients with cancer and central venous catheters. Cochrane Database Systematic Review, CD006468, doi: 10.1002/14651858.CD006468.pub3.
3. Alikhan, R., Cohen, A.T., Combe, S., Samama, M.M., Desjardins, L., Eldor, A., Janbon, C., Leizorovicz, A., Olsson, C.G. & Turpie, A.G. (2004) Risk factors for venous thromboembolism in hospitalized patients with acute medical illness: analysis of the MEDENOX Study. Archives of Internal Medicine, 164, 963-968.
4. Aw, A., Carrier, M., Koczerginski, J., McDiarmid, S. & Tray, J. (2012) Incidence and predictive factors of symptomatic thrombosis related to peripherally inserted central catheters in chemotherapy patients. Thrombosis Research, 130, 323-326.
5. Baglin, T., Barrowcliffe, T., Cohen, A. & Greaves, M. (2006) Guidelines on the use and monitoring of heparin. British Journal of Haematology, 133, 19-34.
6. Baskin, J., Pui, C.-H., Reiss, U., Wilimas, J., Metzger, M., Ribeiro, R. & Howard, S. (2009) Management of occlusion and thrombosis associated with long-term indwelling central venous catheters. Lancet, 374, 159-169.
7. Baskin, J.L., Reiss, U., Wilimas, J.A., Metzger, M.L., Ribeiro, R.C., Pui, C.H. & Howard, S.C. (2012) Thrombolytic therapy for central venous catheter occlusion. Haematologica, 97, 641-650.
8. Beinart, G. & Damon, L. (2004) Thrombosis associated with l-asparaginase therapy and low fibrinogen levels in adult acute lymphoblastic leukemia. American Journal of Hematology, 77, 331-335.
9. Bern, M.M., Lokich, J.J., Wallach, S.R., Bothe, A. Jr, Benotti, P.N., Arkin, C.F., Greco, F.A., Huberman, M. & Moore, C. (1990) Very low doses of warfarin can prevent thrombosis in central venous catheters. A randomized prospective trial. Annals of Internal Medicine, 112, 423-428.
10. Bishop, L., Dougherty, L., Bodenham, A., Mansi, J., Crowe, P., Kibbler, C., Shannon, M. & Treleaven, J. (2007) Guidelines on the insertion and management of central venous access devices in adults. International Journal of Laboratory Hematology, 29, 261-278.
11. Broviac, J., Cole, J. & Scribner, B. (1973) A silicone rubber arterial catheter for prolonged parenteral alimentation. Surgery, Gynecology & Obstetrics, 136, 602-606.
12. Brown-Smith, J.K., Stoner, M.H. & Barley, Z.A. (1990) Tunnelled catheter thrombosis: factors related to incidence. Oncology Nursing Forum, 17, 543-549.
13. Cavanna, L., Civardi, G., Vallisa, D., Di Nunzio, C., Cappucciati, L., Bertè, R., Cordani, M.R., Lazzaro, A., Cremona, G., Biasini, C., Muroni, M., Mordenti, P., Gorgni, S., Zaffignani, E., Ambroggi, M., Bidin, L., Palladino, M.A., Rodinò, C. & Tibaldi, L. (2010) Ultrasound-guided central venous catheterization in cancer patients improves the success rate of cannulation and reduces mechanical complications: a prospective observational study of 1, 978 consecutive catheterizations. World Journal of Surgical Oncology, 19, 8-91.
14. Cortelezzi, A., Fracchiolla, N.S., Maisonneuve, P., Moia, M., Luchesini, C., Ranzi, M.L., Monni, P., Pasquini, M.C. & Lambertenghi-Deliliers, G. (2003) Central venous catheter-related complications in patients with hematological malignancies: a retrospective analysis of risk factors and prophylactic measures. Leukaemia & Lymphoma, 44, 1495-1501.
15. Cortelezzi, A., Moia, M., Falanga, A., Pogliani, E.M., Agnelli, G., Bonizzoni, E., Gussoni, G., Barbui, T., Mannucci, P.M. & CATHEM Study Group (2005) Incidence of thrombotic complications in patients with haematological malignancies with central venous catheters: a prospective multicentre study. British Journal of Haematology, 129, 811-817.
16. Couban, S., Goodyear, M., Burnell, M., Dolan, S., Wasi, P., Barnes, D., Macleod, D., Burton, E., Andreou, P. & Anderson, D.R. (2005) Randomized placebo-controlled study of low-dose warfarin for the prevention of central venous catheter-associated thrombosis in patients with cancer. Journal of Clinical Oncology, 23, 4063-4069.
17. Craft, P.S., May, J., Dorigo, A., Hoy, C. & Plant, A. (1996) Hickman catheters: left-sided insertion, male gender, and obesity are associated with an increased risk of complications. Australian and New Zealand Journal of Medicine, 26, 33-39.
18. De Cicco, M., Matovic, M., Balestreri, L., De Angelis, V., Fracasso, A., Morassut, S., Coran, F., Babare, R., Buonadonna, A. & Testa, V. (1995) Antithrombin III deficiency as a risk factor for catheter-related central vein thrombosis in cancer patients. Thrombosis Research, 78, 127-137.
19. De Cicco, M., Matovic, M., Balestreri, L., Panarello, G., Fantin, D., Morassut, S. & Testa, V. (1997) Central venous thrombosis: an early and frequent complication in cancer patients bearing long-term silastic catheter. A prospective study. Thrombosis Research, 86, 101-113.
20. De Cicco, M., Matovic, M., Balestreri, L., Steffan, A., Pacenzia, R., Malafronte, M., Fantin, D., Bertuzzi, C.A., Fabiani, F., Morassut, S., Bidoli, E. & Veronesi, A. (2009) Early and short-term acenocumarine or dalteparin for the prevention of central vein catheter-related thrombosis in cancer patients: a randomized controlled study based on serial venographies. Annals of Oncology, 20, 1936-1942.
21. Debourdeau, P., Farge, D., Beckers, M., Baglin, C., Bauersachs, R.M., Brenner, B., Brilhante, D., Falanga, A., Gerotzafias, G.T., Haim, N., Kakkar, A.K., Khorana, A.A., Lecumberri, R., Mandala, M., Marty, M., Monreal, M., Mousa, S.A., Noble, S., Pabinger, I., Prandoni, P., Prins, M.H., Qari, M.H., Streiff, M.B., Syrigos, K., Büller, H.R. & Bounameaux, H. (2013) International clinical practice guidelines for the treatment and prophylaxis of thrombosis associated with central venous catheters in patients with cancer. Journal of Thrombosis and Haemostasis, 11, 71-80.
22. Dentali, F., Gianni, M., Agnelli, G. & Ageno, W. (2008) Association between inherited thrombophilic abnormalities and central venous catheter thrombosis in patients with cancer: a meta-analysis. Journal of Thrombosis and Haemostasis, 6, 70-75.
23. Di Nisio, M., Van Sluis, G.L., Bossuyt, P.M., Büller, H.R., Porreca, E. & Rutjes, A.W. (2010) Accuracy of diagnostic tests for clinically suspected upper extremity deep vein thrombosis: a systematic review. Journal of Thrombosis and Haemostasis, 8, 684-692.
24. Eastman, M.E., Khorsand, M., Maki, D.G., Williams, E.C., Kim, K., Sondel, P.M., Schiller, J.H. & Albertini, M.R. (2001) Central venous device-related infection and thrombosis in patients treated with moderate dose continuous-infusion interleukin-2. Cancer, 91, 806-814.
25. Eastridge, B.J. & Lefor, A.T. (1995) Complications of indwelling venous access devices in cancer patients. Journal of Clinical Oncology, 13, 233-238.
26. Elman, E. & Kahn, S. (2006) The post-thrombotic syndrome after upper extremity deep venous thrombosis in adults: a systematic review. Thrombosis Research, 117, 609-614.
27. Evans, R.S., Sharp, J.H., Linford, L.H., Lloyd, J.F., Tripp, J.S., Jones, J.P., Woller, S.C., Stevens, S.M., Elliott, C.G. & Weaver, L.K. (2010) Risk of symptomatic DVT associated with peripherally inserted central catheters. Chest, 138, 803-810.
28. Forauer, A.R., Theoharis, C.G. & Dasika, N.L. (2006) Jugular vein catheter placement: histologic features and development of catheter-related (fibrin) sheaths in a swine model. Radiology, 240, 427-434.
29. Galloway, S. & Bodenham, A. (2004) Long-term central venous access. British Journal of Anaesthesia, 92, 722-734.
30. Gould, J.R., Carloss, H.W. & Skinner, W.L. (1993) Groshong catheter-associated subclavian venous thrombosis. American Journal of Medicine, 95, 419-423.
31. Grove, J.R. & Pevec, W.C. (2000) Venous thrombosis related to peripherally inserted central catheters. Journal of Vascular and Interventional Radiology, 11, 837-840.
32. Henrickson, K.J., Axtell, R.A., Hoover, S.M., Kuhn, S.M., Pritchett, J., Kehl, S.C. & Klein, J.P. (2000) Prevention of central venous catheter-related infections and thrombotic events in immunocompromised children by the use of vancomycin/ciprofloxacin/heparin flush solution: a randomized, multicenter, double-blind trial. Journal of Clinical Oncology, 18, 1269-1278.
33. Hickman, R., Buckner, C., Clift, R., Sanders, J., Stewart, P. & Thomas, E. (1979) A modified right atrial catheter for access to the venous system in marrow transplant recipients. Surg Gynecol Obstet, 148, 871-875.
34. Hoshal, V.L. Jr, Ause, R.G. & Hoskins, P.A. (1971) Fibrin sleeve formation on indwelling subclavian central venous catheters. Archives of Surgery, 102, 253-258.
35. Joffe, H.V. & Goldhaber, S.Z. (2002) Upper-extremity deep vein thrombosis. Circulation, 106, 1874-1880.
36. Kadidal, V.V., Mayo, D.J. & Horne, M.K. (1999) Heparin-induced thrombocytopenia (HIT) due to heparin flushes: a report of three cases. Journal of Internal Medicine, 246, 325-329.
37. Kahn, S., Lim, W., Dunn, A., Cushman, M., Dentali, F., Akl, E., Cook, D., Balekian, A., Klein, R., Le, H., Schulman, S. & Murad, M. (2012) Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis 9th ed ACCP evidence-based clinical practice guidelines. Chest, 141, e195S-e226S.
38. Kakkar, A.K., Levine, M., Pinedo, H.M., Wolff, R. & Wong, J. (2003) Venous thrombosis in cancer patients: iNsights from the FRONTline survey. The oncologist, 8, 381-388.
39. Kamphuisen, P.W. & Lee, A.Y. (2012) Catheter-related thrombosis: lifeline or a pain in the neck? American Society of Hematology Education Program, 2012, 638-644.
40. Karthaus, M., Kretzschmar, A., Kröning, H., Biakhov, M., Irwin, D., Marschner, N., Slabber, C., Fountzilas, G., Garin, A., Abecasis, N.G., Baronius, W., Steger, G.G., Südhoff, T., Giorgetti, C. & Reichardt, P. (2006) Dalteparin for prevention of catheter-related complications in cancer patients with central venous catheters: final results of a double-blind, placebo-controlled phase III trial. Annals of Oncology, 17, 289-296.
41. Kearon, C., Akl, E.A., Comerota, A.J., Prandoni, P., Bounameaux, H., Goldhaber, S.Z., Nelson, M.E., Wells, P.S., Gould, M.K., Dentali, F., Crowther, M., Kahn, S.R. & American College of Chest Physicians (2012) Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th Ed. American College of Chest Physicians Evidence- Based Clinical Practice Guidelines. Chest, 141(Suppl. 2), e419S-e494S.
42. Kim, H.J., Yun, J., Kim, K.H., Kim, S.H., Lee, S.C. & Bae, S.B. (2010) Safety and effectiveness of central venous catheterization in patients with cancer: prospective observational study. Journal of Korean Medical Science, 25, 1748-1753.
43. Kovacs, M.J., Kahn, S.R., Rodger, M., Anderson, D.R., Andreou, R., Mangel, J.E., Morrow, B., Clement, A.M. & Wells, P.S. (2007) A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study). Journal of Thrombosis and Haemostasis, 5, 1650-1653.
44. Kucher, N. (2011) Deep-vein thrombosis of the upper extremities. New England Journal of Medicine, 364, 861-869.
45. Kuter, D.J. (2004) Thrombotic complications of central venous catheters in cancer patients. The oncologist, 9, 207-216.
46. Labourey, J.L., Lacroix, P., Genet, D., Gobeaux, F., Martin, J., Venat-Bouvet, L., Lavau-Denes, S., Maubon, A. & Tubiana-Mathieu, N. (2004) Thrombotic complications of implanted central venous access devices: prospective evaluation. Bulletin du Cancer, 91, 431-436.
47. Lee, A.Y., Levine, M.N., Baker, R.I., Bowden, C., Kakkar, A.K., Prins, M., Rickles, F.R., Julian, J.A., Haley, S., Kovacs, M.J., Gent, M. & for the Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Investigators (2003) Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. New England Journal of Medicine, 349, 146-153.
48. Lee, A.Y., Levine, M.N., Butler, G., Webb, C., Costantini, L., Gu, C. & Julian, J.A. (2006) Incidence, risk factors, and outcomes of catheter-related thrombosis in adult patients with cancer. Journal of Clinical Oncology, 24, 1404-1408.
49. Leebeek, F.W., Stadhouders, N.A., van Stein, D., Gómez-García, E.B. & Kappers-Klunne, M.C. (2001) Hypercoagulability states in upper-extremity deep venous thrombosis. American Journal of Hematology, 67, 15-19.
50. Liem, T.K., Yanit, K.E., Moseley, S.E., Landry, G.J., Deloughery, T.G., Rumwell, C.A., Mitchell, E.L. & Moneta, G.L. (2012) Peripherally inserted central catheter usage patterns and associated symptomatic upper extremity venous thrombosis. Journal of Vascular Surgery, 55, 761-767.
51. Linenberger, M.L. (2006) Catheter-related thrombosis: risks, diagnosis, and management. Journal of the National Comprehensive Cancer Network, 4, 889-901.
52. Luciani, A., Clement, O., Halimi, P., Goudot, D., Portier, F., Bassot, V., Luciani, J.A., Avan, P., Frija, G. & Bonfils, P. (2001) Catheter-related upper extremity deep venous thrombosis in cancer patients: a prospective study based on Doppler US. Radiology, 220, 655-660.
53. Marik, P.E., Flemmer, M. & Harrison, W. (2012) The risk of catheter-related bloodstream infection with femoral venous catheters as compared to subclavian and internal jugular venous catheters: a systematic review of the literature and meta-analysis. Critical Care Medicine, 40, 2479-2485.
54. Massoure, P.L., Constans, J., Caudry, M., Morlat, P., Skopinski, S., Beylot, J., Longy-Boursier, M., Le Bras, M., Combe, C., Quinton, A., Saric, J. & Conri, C. (2000) Upper extremity deep venous thrombosis. 40 hospitalized patients. Journal des Maladies Vasculaires, 25, 250-255.
55. McNulty, I., Katz, E. & Kim, K.Y. (2005) Thrombocytopenia following heparin flush. Progress in Cardiovascular Nursing, 20, 143-147.
56. Merrer, J., De Jonghe, B., Golliot, F., Lefrant, J.Y., Raffy, B., Barre, E., Rigaud, J.P., Casciani, D., Misset, B., Bosquet, C., Outin, H., Brun-Buisson, C., Nitenberg, G. & French Catheter Study Group in Intensive Care (2001) Complications of femoral and subclavian venous catheterization in critically ill patients. A randomized controlled trial. Journal of the American Medical Association, 286, 700-707.
57. Mismetti, P., Mille, D., Laporte, S., Charlet, V., Buchmüller-Cordier, A., Jacquin, J.P., Fournel, P., Dutrey-Dupagne, C., Decousus, H. & CIP Study Group (2003) Low-molecular-weight heparin (nadroparin) and very low doses of warfarin in the prevention of upper extremity thrombosis in cancer patients with indwelling long-term central venous catheters: a pilot randomized trial. Haematologica, 88, 67-73.
58. Mitchell, M.D., Anderson, B.J., Williams, K. & Umscheid, C.A. (2009) Heparin flushing and other interventions to maintain patency of central venous catheters: a systematic review. Journal of Advanced Nursing, 65, 2007-2021.
59. Monreal, M., Raventos, A., Lerma, R., Ruiz, J., Lafoz, E., Alastrue, A. & Llamazares, J.F. (1994) Pulmonary embolism in patients with upper extremity DVT associated to venous central lines-a prospective study. Thrombosis and Haemostasis, 72, 548-550.
60. Monreal, M., Alastrue, A., Rull, M., Mira, X., Muxart, J., Rosell, R. & Abad, A. (1996) Upper extremity deep venous thrombosis in cancer patients with venous access devices-prophylaxis with a low molecular weight heparin (Fragmin). Thrombosis and Haemostasis, 75, 251-253.
61. Muñoz, F.J., Mismetti, P., Poggio, R., Valle, R., Barrón, M., Monreal, M. & RIETE Investigators (2008) Clinical outcome of patients with upper-extremity deep vein thrombosis: results from the RIETE Registry. Chest, 133, 143-148.
62. Mustafa, B.O., Rathbun, S.W., Whitsett, T.L. & Raskob, G.E. (2002) Sensitivity and specificity of ultrasonography in the diagnosis of upper extremity deep vein thrombosis: a systematic review. Archives of Internal Medicine, 162, 401-404.
63. Niers, T.M., Di Nisio, M., Klerk, C.P., Baarslag, H.J., Büller, H.R. & Biemond, B.J. (2007) Prevention of catheter-related venous thrombosis with nadroparin in patients receiving chemotherapy for hematologic malignancies: a randomized, placebo-controlled study. Journal of Thrombosis and Haemostasis, 5, 1878-1882.
64. Palumbo, A., Rajkumar, S.V., Dimopoulos, M.A., Richardson, P.G., San Miguel, J., Barlogie, B., Harousseau, J., Zonder, J.A., Cavo, M., Zangari, M., Attal, M., Belch, A., Knop, S., Joshua, D., Sezer, O., Ludwig, H., Vesole, D., Bladé, J., Kyle, R., Westin, J., Weber, D., Bringhen, S., Niesvizky, R., Waage, A., von Lilienfeld-Toal, M., Lonial, S., Morgan, G.J., Orlowski, R.Z., Shimizu, K., Anderson, K.C., Boccadoro, M., Durie, B.G., Sonneveld, P., Hussein, M.A. & International Myeloma Working Group (2008) Prevention of thalidomide- and lenalidomide-associated thrombosis in myeloma. Leukemia, 22, 414-423.
65. Pottecher, T., Forrler, M., Picardat, P., Krause, D., Bellocq, J.P. & Otteni, J.C. (1984) Thrombogenicity of central venous catheters: prospective study of polyethylene, silicone and polyurethane catheters with phlebography or post-mortem examination. European Journal of Anaesthesiology, 1, 361-365.
66. Raad, I.I., Luna, M., Khalil, S.A., Costerton, J.W., Lam, C. & Bodey, G.P. (1994) The relationship between the thrombotic and infectious complications of central venous catheters. Journal of the American Medical Association, 271, 1014-1016.
67. Ragasa, J., Shah, N. & Watson, R. (1989) Where antecubital catheters go: a study under fluoroscopic control. Anesthesiology, 71, 378-380.
68. Revel-Vilk, S., Chan, A., Bauman, M. & Massicotte, P. (2003) Prothrombotic conditions in an unselected cohort of children with venous thromboembolic disease. Journal of Thrombosis and Haemostasis, 1, 915-921.
69. Revel-Vilk, S., Yacobovich, J., Tamary, H., Goldstein, G., Nemet, S., Weintraub, M., Paltiel, O. & Kenet, G. (2010) Risk factors for central venous catheter thrombotic complications in children and adolescents with cancer. Cancer, 116, 4197-4205.
70. van Rooden, C.J., Schippers, E.F., Barge, R.M., Rosendaal, F.R., Guiot, H.F., van der Meer, F.J., Meinders, A.E. & Huisman, M.V. (2005) Journal of Clinical Oncology, 23, 2655-2660.
71. Saber, W., Moua, T., Williams, E.C., Verso, M., Agnelli, G., Couban, S., Young, A., De Cicco, M., Biffi, R., van Rooden, C.J., Huisman, M.V., Fagnani, D., Cimminiello, C., Moia, M., Magagnoli, M., Povoski, S.P., Malak, S.F. & Lee, A.Y. (2011) Risk factors for catheter-related thrombosis (CRT) in cancer patients: a patient-level data (IPD) meta-analysis of clinical trials and prospective studies. Journal of Thrombosis and Haemostasis, 9, 312-319.
72. Sabeti, S., Schillinger, M., Mlekusch, W., Haumer, M., Ahmadi, R. & Minar, E. (2002) Treatment of subclavian-axillary vein thrombosis: long-term outcome of anticoagulation versus systemic thrombolysis. Thrombosis Research, 108, 279-285.
73. Savage, K.J., Wells, P.S., Schulz, V., Goudie, D., Morrow, B., Cruickshank, M. & Kovacs, M.J. (1999) Outpatient use of low molecular weight heparin (Dalteparin) for the treatment of deep vein thrombosis of the upper extremity. Thrombosis and Haemostasis, 82, 1008-1010.
74. Schmidt, M., Horvath-Puho, E., Thomsen, R.W., Smeeth, L. & Sorensen, H.T. (2012) Acute infections and venous thromboembolism. Journal of Internal Medicine, 271, 608-618.
75. Schwarz, R.E., Coit, D.G. & Groeger, J.S. (2000) Transcutaneously tunnelled central venous lines in cancer patients: an analysis of device-related morbidity factors based on prospective data collection. Annals of Surgical Oncology, 7, 441-449.
76. Shivakumar, S.P., Anderson, D.R. & Couban, S. (2009) Catheter-associated thrombosis in patients with malignancy. Journal of Clinical Oncology, 27, 4858-4864.
77. Siva, S. & Hiremath, H. (2008) Central venous catheters: do we need to review practice on positioning? Journal of International Care Society, 9, 228-231.
78. Sohne, M., Kruip, M.J., Nijkeuter, M., Tick, L., Kwakkel, H., Halkes, S.J., Huisman, M.V., Buller, H.R. & Christoper Study Group (2006) Accuracy of clinical decision rule, D-dimer and spiral computed tomography in patients with malignancy, previous venous thromboembolism, COPD or heart failure and in older patients with suspected pulmonary embolism. Journal of Thrombosis and Haemostasis, 4, 1042-1046.
79. Stephens, L.C., Haire, W.D. & Kotulak, G.D. (1995) Are clinical signs accurate indicators of the cause of central venous catheter occlusion? Journal of Parenteral and Enteral Nutrition, 19, 75-79.
80. Tesselaar, M.E., Ouwerkerk, J., Nooy, M.A., Rosendaal, F.R. & Osanto, S. (2004) Risk factors for catheter-related thrombosis in cancer patients. European Journal of Cancer, 40, 2253-2259.
81. Verso, M. & Agnelli, G. (2003) Venous thromboembolism associated with long-term use of central venous catheters in cancer patients. Journal of Clinical Oncology, 21, 3665-3675.
82. Verso, M., Agnelli, G., Bertoglio, S., Di Somma, F.C., Paoletti, F., Ageno, W., Bazzan, M., Parise, P., Quintavalla, R., Naglieri, E., Santoro, A., Imberti, D., Sorarù, M. & Mosca, S. (2005) Enoxaparin for the prevention of venous thromboembolism associated with central vein catheter: a double-blind, placebo-controlled, randomized study in cancer patients. Journal of Clinical Oncology, 23, 4057-4062.
83. Verso, M., Agnelli, G., Kamphuisen, P.W., Ageno, W., Bazzan, M., Lazzaro, A., Paoletti, F., Paciaroni, M., Mosca, S. & Bertoglio, S. (2008) Risk factors for upper limb deep vein thrombosis associated with the use of central vein catheter in cancer patients. Internal and Emergency Medicine, 3, 117-122.
84. Young, A., Billingham, L., Begum, G., Kerr, D.J., Hughes, A.I., Rea, D.W., Shepherd, S., Stanley, A., Sweeney, A., Wilde, J., Wheatley, K. & WARP Collaborative Group, UK (2009) Warfarin thromboprophylaxis in cancer patients with central venous catheters (WARP): an open-label randomised trial. Lancet, 373, 567-574.