Iron oxide @ polypyrrole nanoparticles as a multifunctional drug carrier for remotely controlled cancer therapy with synergistic antitumor effect

ACS Nano

Volumn 7, Issue 8, 2013, Pages 6782-6795

  Wang, Chao ^a   Xu, Huan ^a   Liang, Chao ^a   Liu, Yumeng ^a   Li, Zhiwei ^a   Yang, Guangbao ^a   Cheng, Liang ^a   Li, Yonggang ^a   Liu, Zhuang ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

cancer combination therapy; drug delivery; iron oxide nanoclusters; magnetic; photothermal; polypyrrole

Indexed keywords

COMBINATION THERAPY; CORE-SHELL NANOPARTICLES; INORGANIC NANOMATERIALS; MAGNETIC; MULTIFUNCTIONAL NANOCOMPOSITES; PHOTO-THERMAL; PHYSIOLOGICAL ENVIRONMENT; POLYMER-BASED NANOCOMPOSITES;

CONTROLLED DRUG DELIVERY; DISEASES; DRUG DELIVERY; INFRARED DEVICES; IRON OXIDES; MAGNETIC RESONANCE IMAGING; NANOCLUSTERS; NANOCOMPOSITES; NANOMAGNETICS; NANOPARTICLES; ORGANIC POLYMERS;

POLYPYRROLES;

ANTINEOPLASTIC AGENT; BIOMATERIAL; DRUG CARRIER; FERRIC ION; FERRIC OXIDE; MACROGOL DERIVATIVE; NANOCOMPOSITE; NANOPARTICLE; POLYMER; POLYPYRROLE; PYRROLE DERIVATIVE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CHEMISTRY; FEMALE; HUMAN; MAGNETISM; METHODOLOGY; MOUSE; NANOTECHNOLOGY; NEOPLASM; NUCLEAR MAGNETIC RESONANCE IMAGING; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; NEOPLASMS; PROCEDURES;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; DRUG CARRIERS; FEMALE; FERRIC COMPOUNDS; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETICS; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; NANOCOMPOSITES; NANOPARTICLES; NANOTECHNOLOGY; NEOPLASM TRANSPLANTATION; NEOPLASMS; POLYETHYLENE GLYCOLS; POLYMERS; PYRROLES;

EID: 84883258982     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn4017179     Document Type: Article

References (54)

1. Huebsch, N.; Mooney, D. J. Inspiration and Application in the Evolution of Biomaterials Nature 2009, 462, 426-432
2. Davis, M. E.; Chen, Z.; Shin, D. M. Nanoparticle Therapeutics: an Emerging Treatment Modality for Cancer Nat. Rev. Drug Discovery 2008, 7, 771-782
3. Troutman, T. S.; Leung, S. J.; Romanowski, M. Light-Induced Content Release from Plasmon-Resonant Liposomes Adv. Mater. 2009, 21, 2334-2338
4. Yang, X.; Liu, X.; Liu, Z.; Pu, F.; Ren, J.; Qu, X. Near-Infrared Light-Triggered, Targeted Drug Delivery to Cancer Cells by Aptamer Gated Nanovehicles Adv. Mater. 2012, 24, 2890-2895
5. Jayakumar, M. K. G.; Idris, N. M.; Zhang, Y. Remote Activation of Biomolecules in Deep Tissues Using Near-Infrared-to-UV Upconversion Nanotransducers Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 8483-8488
6. Baeza, A.; Guisasola, E.; Ruiz-Hernández, E.; Vallet-Regí, M. Magnetically Triggered Multidrug Release by Hybrid Mesoporous Silica Nanoparticles Chem. Mater. 2012, 24, 517-524
7. Ge, J.; Neofytou, E.; Cahill, T. J.; Beygui, R. E.; Zare, R. N. Drug Release from Electric-Field-Responsive Nanoparticles ACS Nano 2012, 6, 227-233
8. Thomas, C. R.; Ferris, D. P.; Lee, J.-H.; Choi, E.; Cho, M. H.; Kim, E. S.; Stoddart, J. F.; Shin, J.-S.; Cheon, J.; Zink, J. I. Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles J. Am. Chem. Soc. 2010, 132, 10623-10625
9. Schroeder, A.; Honen, R.; Turjeman, K.; Gabizon, A.; Kost, J.; Barenholz, Y. Ultrasound Triggered Release of Cisplatin from Liposomes in Murine Tumors J. Controlled Release 2009, 137, 63-68
10. Melancon, M. P.; Zhou, M.; Li, C. Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles Acc. Chem. Res. 2011, 44, 947-956
11. Yang, K.; Zhang, S.; Zhang, G.; Sun, X.; Lee, S. T.; Liu, Z. Graphene in Mice: Ultrahigh in Vivo Tumor Uptake and Efficient Photothermal Therapy Nano Lett. 2010, 10, 3318-3323
12. Liu, X.; Tao, H.; Yang, K.; Zhang, S.; Lee, S. T.; Liu, Z. Optimization of Surface Chemistry on Single-Walled Carbon Nanotubes for in Vivo Photothermal Ablation of Tumors Biomaterials 2011, 32, 144-151
13. Xiao, Z. Y.; Ji, C. W.; Shi, J. J.; Pridgen, E. M.; Frieder, J.; Wu, J.; Farokhzad, O. C. DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy Angew. Chem., Int. Ed. 2012, 51, 11853-11857
14. Kang, H.; Trondoli, A. C.; Zhu, G.; Chen, Y.; Chang, Y. J.; Liu, H.; Huang, Y. F.; Zhang, X.; Tan, W. Near-Infrared Light-Responsive Core-Shell Nanogels for Targeted Drug Delivery ACS Nano 2011, 5, 5094-5099
15. Ma, Y.; Liang, X.; Tong, S.; Bao, G.; Ren, Q.; Dai, Z. Gold Nanoshell Nanomicelles for Potential Magnetic Resonance Imaging, Light-Triggered Drug Release, and Photothermal Therapy Adv. Funct. Mater. 2013, 23, 815-822
16. Zhang, Z.; Wang, L.; Wang, J.; Jiang, X.; Li, X.; Hu, Z.; Ji, Y.; Wu, X.; Chen, C. Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment Adv. Mater. 2012, 24, 1418-1423
17. Chen, J.; Glaus, C.; Laforest, R.; Zhang, Q.; Yang, M.; Gidding, M.; Welch, M. J.; Xia, Y. Gold Nanocages as Photothermal Transducers for Cancer Treatment Small 2010, 6, 811-817
18. Chen, J.; Yang, M.; Zhang, Q.; Cho, E. C.; Cobley, C. M.; Kim, C.; Glaus, C.; Wang, L. V.; Welch, M. J.; Xia, Y. Gold Nanocages: A Novel Class of Multifunctional Nanomaterials for Theranostic Applications Adv. Funct. Mater. 2010, 20, 3684-3694
19. Yang, K.; Wan, J.; Zhang, S.; Tian, B.; Zhang, Y.; Liu, Z. The Influence of Surface Chemistry and Size of Nanoscale Graphene Oxide on Photothermal Therapy of Cancer Using Ultra-Low Laser Power Biomaterials 2012, 33, 2206-2214
20. Huang, X.; Tang, S.; Mu, X.; Dai, Y.; Chen, G.; Zhou, Z.; Ruan, F.; Yang, Z.; Zheng, N. Freestanding Palladium Nanosheets with Plasmonic and Catalytic Properties Nat. Nanotechnol. 2011, 6, 28-32
21. Tian, Q.; Tang, M.; Sun, Y.; Zou, R.; Chen, Z.; Zhu, M.; Yang, S.; Wang, J.; Wang, J.; Hu, J. Hydrophilic Flower-Like CuS Superstructures as an Efficient 980 nm Laser-Driven Photothermal Agent for Ablation of Cancer Cells Adv. Mater. 2011, 23, 3542-3547
22. Cheng, L.; Yang, K.; Chen, Q.; Liu, Z. Organic Stealth Nanoparticles for Highly Effective in Vivo Near-Infrared Photothermal Therapy of Cancer ACS Nano 2012, 6, 5605-5613
23. Peer, D.; Karp, J. M.; Hong, S.; Farokhzad, O. C.; Margalit, R.; Langer, R. Nanocarriers as an Emerging Platform for Cancer Therapy Nat. Nanotechnol. 2007, 2, 751-760
24. Yang, K.; Xu, H.; Cheng, L.; Sun, C.; Wang, J.; Liu, Z. In Vitro and in Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles Adv. Mater. 2012, 24, 5586-5592
25. Yang, J.; Choi, J.; Bang, D.; Kim, E.; Lim, E.-K.; Park, H.; Suh, J.-S.; Lee, K.; Yoo, K.-H.; Kim, E.-K. et al. Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells Angew. Chem., Int. Ed. 2011, 50, 441-444
26. Oh, W. K.; Yoon, H.; Jang, J. Size Control of Magnetic Carbon Nanoparticles for Drug Delivery Biomaterials 2010, 31, 1342-1348
27. George, P. M.; Lyckman, A. W.; LaVan, D. A.; Hegde, A.; Leung, Y.; Avasare, R.; Testa, C.; Alexander, P. M.; Langer, R.; Sur, M. Fabrication and Biocompatibility of Polypyrrole Implants Suitable for Neural Prosthetics Biomaterials 2005, 26, 3511-3519
28. Fonner, J. M.; Forciniti, L.; Nguyen, H.; Byrne, J. D.; Kou, Y. F.; Syeda-Nawaz, J.; Schmidt, C. E. Biocompatibility Implications of Polypyrrole Synthesis Techniques Biomed. Mater. 2008, 3, 034124
29. Ramanaviciene, A.; Kausaite, A.; Tautkus, S.; Ramanavicius, A. Biocompatibility of Polypyrrole Particles: An in-Vivo Study in Mice J. Pharm. Pharmacol. 2007, 59, 311-315
30. Wang, X. D.; Gu, X. S.; Yuan, C. W.; Chen, S. J.; Zhang, P. Y.; Zhang, T. Y.; Yao, J.; Chen, F.; Chen, G. Evaluation of Biocompatibility of Polypyrrole in Vitro and in Vivo J. Biomed. Mater. Res. Part A 2004, 68, 411-422
31. Abidian, M. R.; Corey, J. M.; Kipke, D. R.; Martin, D. C. Conducting-Polymer Nanotubes Improve Electrical Properties, Mechanical Adhesion, Neural Attachment, and Neurite Outgrowth of Neural Electrodes Small 2010, 6, 421-429
32. Yoon, H.; Lee, S. H.; Kwon, O. S.; Song, H. S.; Oh, E. H.; Park, T. H.; Jang, J. Polypyrrole Nanotubes Conjugated with Human Olfactory Receptors: High-Performance Transducers for FET-Type Bioelectronic Noses Angew. Chem., Int. Ed. 2009, 48, 2755-2758
33. Kwon, O. S.; Park, S. J.; Jang, J. A High-Performance VEGF Aptamer Functionalized Polypyrrole Nanotube Biosensor Biomaterials 2010, 31, 4740-4747
34. Runge, M. B.; Dadsetan, M.; Baltrusaitis, J.; Ruesink, T.; Lu, L. C.; Windebank, A. J.; Yaszemski, M. J. Development of Electrically Conductive Oligo(polyethylene glycol) Fumarate-Polypyrrole Hydrogels for Nerve Regeneration Biomacromolecules 2010, 11, 2845-2853
35. Runge, M. B.; Dadsetan, M.; Baltrusaitis, J.; Knight, A. M.; Ruesink, T.; Lazcano, E. A.; Lu, L.; Windebank, A. J.; Yaszemski, M. J. The Development of Electrically Conductive Polycaprolactone Fumarate-Polypyrrole Composite Materials for Nerve Regeneration Biomaterials 2010, 31, 5916-5926
36. Chen, M.; Fang, X.; Tang, S.; Zheng, N. Polypyrrole Nanoparticles for High-Performance in Vivo Near-Infrared Photothermal Cancer Therapy Chem. Commun. (Cambridge, U.K.) 2012, 48, 8934-8936
37. Zha, Z.; Yue, X.; Ren, Q.; Dai, Z. Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells Adv. Mater. 2013, 25, 777-782
38. Xuan, S. H.; Wang, F.; Wang, Y. X. J.; Yu, J. C.; Leung, K. C. F. Facile Synthesis of Size-Controllable Monodispersed Ferrite Nanospheres J. Mater. Chem. 2010, 20, 5086-5094
39. Wang, C.; Cheng, L.; Liu, Z. Drug Delivery with Upconversion Nanoparticles for Multi-functional Targeted Cancer Cell Imaging and Therapy Biomaterials 2011, 32, 1110-1120
40. Wang, C.; Ma, X. X.; Ye, S. Q.; Cheng, L.; Yang, K.; Guo, L.; Li, C. H.; Li, Y. G.; Liu, Z. Protamine Functionalized Single-Walled Carbon Nanotubes for Stem Cell Labeling and in Vivo Raman/Magnetic Resonance/Photoacoustic Triple-Modal Imaging Adv. Funct. Mater. 2012, 22, 2363-2375
41. Wang, C.; Cheng, L.; Xu, H.; Liu, Z. Towards Whole-Body Imaging at the Single Cell Level Using Ultra-sensitive Stem Cell Labeling with Oligo-arginine Modified Upconversion Nanoparticles Biomaterials 2012, 33, 4872-4881
42. Liu, Z.; Sun, X. M.; Nakayama-Ratchford, N.; Dai, H. J. Supramolecular Chemistry on Water-Soluble Carbon Nanotubes for Drug Loading and Delivery ACS Nano 2007, 1, 50-56
43. Liu, Z.; Robinson, J. T.; Sun, X. M.; Dai, H. J. PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs J. Am. Chem. Soc. 2008, 130, 10876-10877
44. Liu, Z.; Fan, A. C.; Rakhra, K.; Sherlock, S.; Goodwin, A.; Chen, X. Y.; Yang, Q. W.; Felsher, D. W.; Dai, H. J. Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for in Vivo Cancer Therapy Angew. Chem., Int. Ed. 2009, 48, 7668-7672
45. Tian, B.; Wang, C.; Zhang, S.; Feng, L. Z.; Liu, Z. Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide ACS Nano 2011, 5, 7000-7009
46. Feng, L.; Yang, X.; Shi, X.; Tan, X.; Peng, R.; Wang, J.; Liu, Z. Polyethylene Glycol and Polyethylenimine Dual-Functionalized Nano-Graphene Oxide for Photothermally Enhanced Gene Delivery Small 2013, 10.1002/smll.201202538
47. Sherlock, S. P.; Tabakman, S. M.; Xie, L. M.; Dai, H. J. Photothermally Enhanced Drug Delivery by Ultrasmall Multifunctional FeCo/Graphitic Shell Nanocrystals ACS Nano 2011, 5, 1505-1512
48. Sherlock, S. P.; Dai, H. J. Multifunctional FeCo-graphitic Carbon Nanocrystals for Combined Imaging, Drug Delivery and Tumor-Specific Photothermal Therapy in Mice Nano Res. 2011, 4, 1248-1260
49. Laginha, K. M.; Verwoert, S.; Charrois, G. J. R.; Allen, T. M. Determination of Doxorubicin Levels in Whole Tumor and Tumor Nuclei in Murine Breast Cancer Tumors Clin. Cancer. Res. 2005, 11, 6944-6949
50. Atkinson, R. L.; Zhang, M.; Diagaradjane, P.; Peddibhotla, S.; Contreras, A.; Hilsenbeck, S. G.; Woodward, W. A.; Krishnan, S.; Chang, J. C.; Rosen, J. M. Thermal Enhancement with Optically Activated Gold Nanoshells Sensitizes Breast Cancer Stem Cells to Radiation Therapy Sci. Transl. Med. 2010, 2, 55ra79-55ra79
51. Pelicci, P. G.; Dalton, P.; Orecchia, R. Heating Cancer Stem Cells to Reduce Tumor Relapse Breast Cancer Res. 2011, 13, 305-307
52. Core, D. M. Hyperthermia and Cancer; Plenum Press: New York, 1982.
53. Gabai, V. L.; Meriin, A. B.; Yaglom, J. A.; Volloch, V. Z.; Sherman, M. Y. Role of Hsp70 in Regulation of Stress-Kinase JNK: Implications in Apoptosis and Aging FEBS Lett. 1998, 438, 1-4
54. Mukhopadhaya, A.; Mendecki, J.; Dong, X. Y.; Liu, L. B.; Kalnicki, S.; Garg, M.; Alfieri, A.; Guha, C. Localized Hyperthermia Combined with Intratumoral Dendritic Cells Induces Systemic Antitumor Immunity Cancer Res. 2007, 67, 7798-7806