Chronic bovine besnoitiosis: Intra-organ parasite distribution, parasite loads and parasite-associated lesions in subclinical cases

Veterinary Parasitology

Volumn 197, Issue 1-2, 2013, Pages 95-103

  Frey, C F ^a,b   Gutierrez Exposito D ^a   Ortega Mora, L M ^a   Benavides, J ^c   Marcen J M ^d   Castillo, J A ^d   Casasus I ^e   Sanz, A ^e   Garcia Lunar P ^a   Esteban Gil, A ^d   Alvarez Garcia G ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF BERN   (Switzerland)

^c Instituto de Ganadería de Montana   (Spain)

^d UNIVERSITY OF ZARAGOZA   (Spain)

^e Agrifood Institute of Aragón IA2   (Spain)

Author keywords

Besnoitia besnoiti; Bovine besnoitiosis; Histopathology; IHQ; Quantitative real time PCR; Subclinical infection

Indexed keywords

PARASITE ANTIBODY;

ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; ASYMPTOMATIC INFECTION; BESNOITIOSIS; CONJUNCTIVA; CONTROLLED STUDY; COW; CYST (RESTING STAGE); FEMALE; GENITAL SYSTEM; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; MACROPHAGE; MONOCYTE; NONHUMAN; PARASITE LOAD; PARASITE LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SEROCONVERSION; SKIN; T LYMPHOCYTE; UPPER RESPIRATORY TRACT; VAGINA; VULVA;

ANIMALIA; BESNOITIA; BESNOITIA BESNOITI; BOVINAE;

BESNOITIA BESNOITI; BOVINE BESNOITIOSIS; HISTOPATHOLOGY; IHQ; QUANTITATIVE REAL-TIME PCR; SUBCLINICAL INFECTION;

ANIMALS; CATTLE; CATTLE DISEASES; CHRONIC DISEASE; COCCIDIOSIS; FEMALE;

EID: 84883247578     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2013.04.023     Document Type: Article

References (38)

1. Agosti M., Belloni A., Morini Vacirca G. Segnalazione di un focolaio di Besnoitiosi in bovini da carne importati. Praxis 1994, 15:5-6.
2. Basso W., Schares G., Gollnick N.S., Rutten M., Deplazes P. Exploring the life cycle of Besnoitia besnoiti - experimental infection of putative definitive and intermediate host species. Vet. Parasitol. 2011, 178(3-4):223-234.
3. Basson P.A., McCully R.M., Bigalke R.D. Observations on the pathogenesis of bovine and antelope strains of Besnoitia besnoiti (Marotel, 1912) infection in cattle and rabbits. Onderstepoort J. Vet. Res. 1970, 37(2):105-126.
4. Besnoit C., Robin V. Sarcosporidiose Cutanée Chez Une Vache. Rev. Med. Vet. 1912, 37:649-663.
5. Bigalke R.D. New concepts on the epidemiological features of bovine besnoitiosis as determined by laboratory and field investigations. Onderstepoort J. Vet. Res. 1968, 35(1):3-137.
6. Collantes-Fernández E., Zaballos A., Álvarez-García G., Ortega-Mora L.M. Quantitative detection of Neospora caninum in bovine aborted fetuses and experimentally infected mice by real-time PCR. J. Clin. Microbiol. 2002, 40(4):1194-1198.
7. Cortes H.C., Leitão A., Vidal R., Vila-Viçosa M.J., Ferreira M.L., Caeiro V., Hjerpe C.A. Besnoitiosis in bulls in Portugal. Vet. Rec. 2005, 157(9):262-264.
8. Cortes H.C., Reis Y., Gottstein B., Hemphill A., Leitao A., Muller N. Application of conventional and real-time fluorescent ITS1 rDNA PCR for detection of Besnoitia besnoiti infections in bovine skin biopsies. Vet. Parasitol. 2007, 146(3-4):352-356.
9. Diesing L., Heydorn A.O., Matuschka F.R., Bauer C., Pipano E., de Waal D.T., Potgieter F.T. Besnoitia besnoiti: studies on the definitive host and experimental infections in cattle. Parasitol. Res. 1988, 75(2):114-117.
10. Dubey J.P., Lindsay D.S., Rosenthal B.M., Sreekumar C., Hill D.E., Shen S.K., Kwok O.C., Rickard L.G., Black S.S., Rashmir-Raven A. Establishment of Besnoitia darlingi from opossums (Didelphis virginiana) in experimental intermediate and definitive hosts, propagation in cell culture, and description of ultrastructural and genetic characteristics. Int. J. Parasitol. 2002, 32(8):1053-1064.
11. Dubey J.P., Lindsay D.S. Development and ultrastructure of Besnoitia oryctofelisi tachyzoites, tissue cysts, bradyzoites, schizonts and merozoites. Int. J. Parasitol. 2003, 33(8):807-819.
12. Dubey J.P., Yabsley M.J. Besnoitia neotomofelis n. sp. (Protozoa: Apicomplexa) from the southern plains woodrat (Neotoma micropus). Parasitology 2010, 137(12):1731-1747.
13. Ducrocq J., Beauchamp G., Kutz S., Simard M., Elkin B., Croft B., Taillon J., Cote S.D., Brodeur V., Campbell M., Cooley D., Cuyler C., Lair S. Comparison of gross visual and microscopic assessment of four anatomic sites to monitor Besnoitia tarandi in barren-ground caribou (Rangifer tarandus). J. Wildl. Dis. 2012, 48(3):732-738.
14. EFSA European Food Safety Authority Bovine Besnoitiosis: an emerging disease in Europe. EFSA J. 2010, 8:1499. Scientific statement on Bovine Besnoitiosis. Question No. EFSA-Q-2009-00879, adopted 28.01.2010. http://www.efsa.europa.eu/en/scdocs/1499.htm.
15. Fernández-García A., Risco-Castillo V., Pedraza-Díaz S., Aguado-Martínez A., Álvarez-García G., Gómez-Bautista M., Collantes-Fernández E., Ortega-Mora L.M. First isolation of Besnoitia besnoiti from a chronically infected cow in Spain. J. Parasitol. 2009, 95(2):474-476.
16. Fernández-Garcia A., Álvarez-García G., Risco-Castillo V., Aguado-Martínez A., Marcen J.M., Rojo-Montejo S., Castillo J.A., Ortega-Mora L.M. Development and use of an indirect ELISA in an outbreak of bovine besnoitiosis in Spain. Vet. Rec. 2010, 166(26):818-822.
17. García-Lunar P., Ortega-Mora L.M., Schares G., Gollnick N.S., Jacquiet P., Grisez C., Prevot F., Frey C.F., Gottstein B., Álvarez-García G. An inter-laboratory comparative study of serological tools employed in the diagnosis of Besnoitia besnoiti infection in bovines. Transbound. Emerg. Dis. 2012, 10.1111/j. 1865-1682.2012.01318.x.
18. Gentile A., Militerno G., Schares G., Nanni A., Testoni S., Bassi P., Gollnick N.S. Evidence for bovine besnoitiosis being endemic in Italy-First in vitro isolation of Besnoitia besnoiti from cattle born in Italy. Vet. Parasitol. 2012, 184(2-4):108-115.
19. Gollnick N.S., Gentile A., Schares G. Diagnosis of bovine besnoitiosis in a bull born in Italy. Vet. Rec. 2010, 166(19):599.
20. Gutiérrez-Expósito D., Ortega-Mora L.M., Gajadhar A.A., García-Lunar P., Dubey J.P., Álvarez-García G. Serological evidence of Besnoitia spp. infection in Canadian wild ruminants and strong cross-reaction between Besnoitia besnoiti and Besnoitia tarandi. Vet. Parasitol. 2012, 190(1-2):19-28.
21. Kumi-Diaka J., Wilson S., Sanusi A., Njoku C.E., Osori D.I. Bovine besnoitiosis and its effect on the male reproductive system. Theriogenology 1981, 16(5):523-530.
22. Lesser M., Braun U., Deplazes P., Gottstein B., Hilbe M., Basso W. First cases of besnoitiosis in cattle in Switzerland. Schweiz. Arch. Tierheilkd. 2012, 154(11):469-474.
23. Liénard E., Salem A., Grisez C., Prévot F., Bergeaud J.P., Franc M., Gottstein B., Alzieu J.P., Lagalisse Y., Jacquiet P. A longitudinal study of Besnoitia besnoiti infections and seasonal abundance of Stomoxys calcitrans in a dairy cattle farm of southwest France. Vet. Parasitol. 2011, 177(1-2):20-27.
24. Liénard E., Salem A., Jacquiet P., Grisez C., Prévot F., Blanchard B., Bouhsira E., Franc M. Development of a protocol testing the ability of Stomoxys calcitrans (Linnaeus, 1758) (Diptera: Muscidae) to transmit Besnoitia besnoiti (Henry, 1913) (Apicomplexa: Sarcocystidae). Parasitol. Res. 2012, 10.1007/s00436-012-3157-6.
25. Majzoub M., Breuer W., Gollnick N.S., Rostaher A., Schares G., Hermanns W. Ein Ausbruch von Besnoitiose bei Rindern in Deutschland: pathomorphologische ultrastrukturelle und molekularbiologische Untersuchungen. Wien. Tierarztl. Monatsschr. 2010, 97:9-15.
26. Manuali E., Lepri E., Salamida S., D'Avino N., Mangili P., Vitellozzi G., Grelloni V., Filippini G. An outbreak of bovine besnoitiosis in beef cattle born in central Italy. Transbound. Emerg. Dis. 2011, 58(5):464-467.
27. McCully R.M., Basson P.A., Van Niekerk J.W., Bigalkie R.D. Observations on Besnoitia cysts in the cardiovascular system of some wild antelopes and domestic cattle. Onderstepoort J. Vet. Res. 1966, 33(2):245-276.
28. Mehlhorn H., Klimpel S., Schein E., Heydorn A.O., Al-Quraishy S., Selmair J. Another African disease in Central Europa: Besnoitiosis of cattle. I. Light and electron microscopical study. Parasitol. Res. 2009, 104(4):861-868.
29. Ness S.L., Peters-Kennedy J., Schares G., Dubey J.P., Mittel L.D., Mohammed H.O., Bowman D.D., Felippe M.J., Wade S.E., Shultz N., Divers T.J. Investigation of an outbreak of besnoitiosis in donkeys in northeastern Pennsylvania. J. Am. Vet. Med. Assoc. 2012, 240(11):1329-1337.
30. Nobel T.A., Klopfer U., Perl S., Nyska A., Neumann M., Brenner G. Histopathology of genital besnoitiosis of cows in Israel. Vet. Parasitol. 1981, 8:271-276.
31. Pols J.W. Studies on bovine besnoitiosis with special reference to the aetiology. Onderstepoort J. Vet. Res. 1960, 28(3):265-356.
32. Rostaher A., Mueller R.S., Majzoub M., Schares G., Gollnick N.S. Bovine besnoitiosis in Germany. Vet. Dermatol. 2010, 21:329-334.
33. Schares G., Basso W., Majzoub M., Cortes H.C., Rostaher A., Selmair J., Hermanns W., Conraths F.J., Gollnick N.S. First in vitro isolation of Besnoitia besnoiti from chronically infected cattle in Germany. Vet. Parasitol. 2009, 163(4):315-322.
34. Schares G., Basso W., Majzoub M., Rostaher A., Scharr J.C., Langenmayer M.C., Selmair J., Dubey J.P., Cortes H.C., Conraths F.J., Gollnick N.S. Comparative evaluation of immunofluorescent antibody and new immunoblot tests for the specific detection of antibodies against Besnoitia besnoiti tachyzoites and bradyzoites in bovine sera. Vet. Parasitol. 2010, 171(1-2):32-40.
35. Schares G., Maksimov A., Basso W., More G., Dubey J.P., Rosenthal B., Majzoub M., Rostaher A., Selmair J., Langenmayer M.C., Scharr J.C., Conraths F.J., Gollnick N.S. Quantitative real time polymerase chain reaction assays for the sensitive detection of Besnoitia besnoiti infection in cattle. Vet. Parasitol. 2011, 178(3-4):208-216.
36. Schulz K.C.A. A report on naturally acquired besnoitiosis in bovines with special reference to its pathology. J. S. Afr. Vet. Med. Assoc. 1960, 31:21-35.
37. Soulas C., Conerly C., Kim W.K., Burdo T.H., Álvarez X., Lackner A.A., Williams K.C. Recently infiltrating MAC387(+)monocytes/macrophages a third macrophage population involved in SIV and HIV encephalitic lesion formation. Am. J. Pathol. 2011, 178(5):2121-2135.
38. Thrusfield M. Diagnostic testing. Veterinary Epidemiology 1995, 266-285. Blackwell, Oxford, U.K. 2nd ed.