CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of hepatitis C virus-infected cells and induction of interferon-alpha

Hepatology

Volumn 58, Issue 3, 2013, Pages 940-949

  Zhang, Shuye ^a   Kodys, Karen ^a   Babcock, Gregory J ^a   Szabo, Gyongyi ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD81 ANTIGEN; CD9 ANTIGEN; RAC PROTEIN; TOLL LIKE RECEPTOR 7; VIRUS RNA;

ANTIGEN RECOGNITION; ARTICLE; CELL CONTACT; CELL LOSS; CELL MEMBRANE; COCULTURE; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME INHIBITION; HEPATITIS C; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTERFERON INDUCTION; INTERFERON PRODUCTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; REPLICON; VIRUS IMMUNITY; VIRUS PARTICLE; VIRUS REPLICATION;

ANTIGENS, CD81; ANTIGENS, CD9; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; CELL COMMUNICATION; CELL LINE, TUMOR; COCULTURE TECHNIQUES; DENDRITIC CELLS; ENDOCYTOSIS; HEPACIVIRUS; HEPATITIS C; HEPATOCYTES; HUMANS; INTERFERON-ALPHA; LEUKOCYTES, MONONUCLEAR; LIVER NEOPLASMS; MEMBRANE MICRODOMAINS; TETRASPANINS; VIRUS REPLICATION;

EID: 84883239355     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25827     Document Type: Article

References (34)

1. Moradpour D, Penin F, Rice CM.Replication of hepatitis C virus.Nat Rev Microbiol 2007;5:453-463.
2. Rehermann B, Nascimbeni M.Immunology of hepatitis B virus and hepatitis C virus infection.Nat Rev Immunol 2005;5:215-229.
3. Feld JJ, Hoofnagle JH.Mechanism of action of interferon and ribavirin in treatment of hepatitis C.Nature 2005;436:967-972.
4. Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J.Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.Nature 2005;437:1167-1172.
5. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, et al.Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF.Proc Natl Acad Sci U S A 2005;102:2992-2997.
6. Sarasin-Filipowicz M, Oakeley EJ, Duong FH, Christen V, Terracciano L, Filipowicz W, Heim MH.Interferon signaling and treatment outcome in chronic hepatitis C.Proc Natl Acad Sci U S A 2008;105:7034-7039.
7. Lau DT, Fish PM, Sinha M, Owen DM, Lemon SM, Gale M, Jr.Interferon regulatory factor-3 activation, hepatic interferon-stimulated gene expression, and immune cell infiltration in hepatitis C virus patients.Hepatology 2008;47:799-809.
8. Gilliet M, Cao W, Liu YJ.Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases.Nat Rev Immunol 2008;8:594-606.
9. Barton GM, Kagan JC.A cell biological view of Toll-like receptor function: regulation through compartmentalization.Nat Rev Immunol 2009;9:535-542.
10. Ebihara T, Shingai M, Matsumoto M, Wakita T, Seya T.Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells.Hepatology 2008;48:48-58.
11. Shiina M, Rehermann B.Cell culture-produced hepatitis C virus impairs plasmacytoid dendritic cell function.Hepatology 2008;47:385-395.
12. Gondois-Rey F, Dental C, Halfon P, Baumert TF, Olive D, Hirsch I.Hepatitis C virus is a weak inducer of interferon alpha in plasmacytoid dendritic cells in comparison with influenza and human herpesvirus type-1.PLoS One 2009;4:e4319.
13. Takahashi K, Asabe S, Wieland S, Garaigorta U, Gastaminza P, Isogawa M, Chisari FV.Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection.Proc Natl Acad Sci U S A 2010;107:7431-7436.
14. von Hahn T, Rice CM.Hepatitis C virus entry.J Biol Chem 2008;283:3689-3693.
15. Farquhar MJ, Harris HJ, McKeating JA.Hepatitis C virus entry and the tetraspanin CD81.Biochem Soc Trans 2011;39:532-536.
16. Broering TJ, Garrity KA, Boatright NK, Sloan SE, Sandor F, Thomas WDJr., et al.Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus.J Virol 2009;83:12473-12482.
17. Yanez-Mo M, Barreiro O, Gordon-Alonso M, Sala-Valdes M, Sanchez-Madrid F.Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes.Trends Cell Biol 2009;19:434-446.
18. Silvie O, Charrin S, Billard M, Franetich JF, Clark KL, van Gemert GJ, et al.Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites.J Cell Sci 2006;119:1992-2002.
19. Levy S, Shoham T.The tetraspanin web modulates immune-signalling complexes.Nat Rev Immunol 2005;5:136-148.
20. Charrin S, Manie S, Thiele C, Billard M, Gerlier D, Boucheix C, Rubinstein E.A physical and functional link between cholesterol and tetraspanins.Eur J Immunol 2003;33:2479-2489.
21. Coffey GP, Rajapaksa R, Liu R, Sharpe O, Kuo CC, Krauss SW, et al.Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin.J Cell Sci 2009;122:3137-3144.
22. Brazzoli M, Bianchi A, Filippini S, Weiner A, Zhu Q, Pizza M, Crotta S.CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes.J Virol 2008;82:8316-8329.
23. Quast T, Eppler F, Semmling V, Schild C, Homsi Y, Levy S, et al.CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration.Blood 2011;118:1818-1827.
24. Lui G, Manches O, Angel J, Molens JP, Chaperot L, Plumas J.Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells.PLoS One 2009;4:e7111.
25. Schmidt B, Ashlock BM, Foster H, Fujimura SH, Levy JA.HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration.Virology 2005;343:256-266.
26. Lepelley A, Louis S, Sourisseau M, Law HK, Pothlichet J, Schilte C, et al.Innate sensing of HIV-infected cells.PLoS Pathog 2011;7:e1001284.
27. Murakami H, Akbar SM, Matsui H, Horiike N, Onji M.Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C.Clin Exp Immunol 2004;137:559-565.
28. Mengshol JA, Golden-Mason L, Castelblanco N, Im KA, Dillon SM, Wilson CC, Rosen HR.Impaired plasmacytoid dendritic cell maturation and differential chemotaxis in chronic hepatitis C virus: associations with antiviral treatment outcomes.Gut 2009;58:964-973.
29. Wertheimer AM, Bakke A, Rosen HR.Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease.Hepatology 2004;40:335-345.
30. Szabo G, Dolganiuc A.Subversion of plasmacytoid and myeloid dendritic cell functions in chronic HCV infection.Immunobiology 2005;210:237-247.
31. Swiecki M, Wang Y, Vermi W, Gilfillan S, Schreiber RD, Colonna M.Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo.J Exp Med 2011;208:2367-2374.
32. Nattermann J, Zimmermann H, Iwan A, von Lilienfeld-Toal M, Leifeld L, Langhans B, et al.Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C.Hepatology 2006;44:945-954.
33. Crotta S, Stilla A, Wack A, D'Andrea A, Nuti S, D'Oro U, et al.Inhibition of natural killer cells through engagement of CD81 by the major hepatitis C virus envelope protein.J Exp Med 2002;195:35-41.
34. Tseng CT, Klimpel GR.Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions.J Exp Med 2002;195:43-49.