Redirecting neutrophils against bladder cancer cells by BCG and Smac mimetic combination

OncoImmunology

Volumn 1, Issue 7, 2012, Pages 1161-1162

  Jinesh, Goodwin G ^a   Kamat, Ashish M ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

BCG; Bladder cancer; FASL; Neutrophils; Smac mimetics; TNF ; TRAIL

Indexed keywords

BCG VACCINE; FAS LIGAND; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER IMMUNOTHERAPY; CHEMOSENSITIZATION; DRUG RESPONSE; HUMAN; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TUMOR MICROENVIRONMENT;

EID: 84883237221     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.20928     Document Type: Article

References (7)

1. Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol 2012; 12:253-68; PMID:22437938; http://dx.doi.org/10.1038/nri3175.
2. Suttmann H, Riemensberger J, Bentien G, Schmaltz D, Stöckle M, Jocham D, et al. Neutrophil granulocytes are required for effective Bacillus Calmette-Guérin immunotherapy of bladder cancer and orchestrate local immune responses. Cancer Res 2006; 66:8250-7; PMID:16912205; http://dx.doi.org/10.1158/0008-5472.CAN-06-1416.
3. de Boer EC, de Jong WH, van der Meijden AP, Steerenberg PA, Witjes F, Vegt PD, et al. Leukocytes in the urine after intravesical BCG treatment for superficial bladder cancer. A flow cytofluorometric analysis. Urol Res 1991; 19:45-50; PMID:2028562; http:// dx.doi.org/10.1007/BF00294021.
4. Ethuin F, Gérard B, Benna JE, Boutten A, Gougereot-Pocidalo MA, Jacob L, et al. Human neutrophils produce interferon gamma upon stimulation by interleukin-12. Lab Invest 2004; 84:1363-71; PMID:15220936; http://dx.doi.org/10.1038/labinvest. 3700148.
5. Jinesh GG, Chunduru S, Kamat AM. Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNFalpha but not through TRAIL and FasL. J Leukoc Biol 2012; In Press; PMID: 22517918.
6. Kemp TJ, Ludwig AT, Earel JK, Moore JM, Vanoosten RL, Moses B, et al. Neutrophil stimulation with Mycobacterium bovis bacillus Calmette-Guerin (BCG) results in the release of functional soluble TRAIL/ Apo-2L. Blood 2005; 106:3474-82; PMID:16037389; http://dx.doi.org/10.1182/blood-2005-03-1327.
7. Fulda S, Vucic D. Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov 2012; 11:109-24; PMID:22293567; http://dx.doi.org/10.1038/nrd3627.