Group-based trajectory models: A new approach to classifying and predicting long-term medication adherence

Medical Care

Volumn 51, Issue 9, 2013, Pages 789-796

  Franklin, Jessica M ^a   Shrank, William H ^a   Pakes, Juliana ^a   Sanfélix Gimeno, Gabriel ^a,b,c   Matlin, Olga S ^d   Brennan, Troyen A ^d   Choudhry, Niteesh K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c Centro Superior de Investigacion en Salud Publica   (Spain)

^d CVS Caremark   (United States)

Author keywords

Adherence; Comparative effectiveness; Latent class; Longitudinal data

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ACCURACY; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; GROUP BASED TRAJECTORY MODEL; HUMAN; LOGISTIC REGRESSION ANALYSIS; MEDICATION COMPLIANCE; PATIENT CODING; PATIENT COMPLIANCE; PRESCRIPTION; PRIORITY JOURNAL; STATISTICAL MODEL;

ADULT; AGE FACTORS; AGED; DRUG UTILIZATION; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INSURANCE CLAIM REVIEW; MALE; MEDICARE; MEDICATION ADHERENCE; MIDDLE AGED; RESIDENCE CHARACTERISTICS; SOCIOECONOMIC FACTORS; UNITED STATES;

EID: 84883215270     PISSN: 00257079     EISSN: 15371948     Source Type: Journal    
DOI: 10.1097/MLR.0b013e3182984c1f     Document Type: Article

References (38)

1. Choudhry NK, Setoguchi S, Levin R, et al. Trends in adherence to secondary prevention medications in elderly post-myocardial infarction patients. Pharmacoepidemiol Drug Saf. 2008;17: 1189-1196.
2. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353: 487-497.
3. Brookhart MA, Patrick AR, Dormuth C, et al. Adherence to lipidlowering therapy and the use of preventive health services: an investigation of the healthy user effect. Am J Epidemiol. 2007;166: 348-354.
4. Caro JJ, Salas M, Speckman JL, et al. Persistence with treatment for hypertension in actual practice. Can Med Assoc J. 1999;160: 31-37.
5. Solomon DH, Avorn J, Katz JN, et al. Compliance with osteoporosis medications. Arch Intern Med. 2005;165: 2414-2419.
6. Cutrona SL, Choudhry NK, Fischer MA, et al. Targeting cardiovascular medication adherence interventions. J Am Pharm Assoc. 2012;52: 381-397.
7. Ho PM, Bryson CL, Rumsfeld JS. Medication adherence. Circulation. 2009;119: 3028-3035.
8. Steiner JF, Koepsell TD, Fihn SD, et al. A general method of compliance assessment using centralized pharmacy records: description and validation. Med Care. 1988;26: 814-823.
9. Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50: 105-116.
10. Nagin D. Group-based Modeling of Development. Cambridge, MA: Harvard University Press; 2005.
11. Nagin DS. Analyzing developmental trajectories: a semiparametric, group-based approach. Psychol Methods. 1999;4: 139-157.
12. Caldeira KM, O'Grady KE, Garnier-Dykstra LM, et al. Cigarette smoking among college students: longitudinal trajectories and health outcomes. Nicotine Tob Res. 2012;14: 777-785.
13. Conklin CA, Perkins KA, Sheidow AJ, et al. The return to smoking: 1-year relapse trajectories among female smokers. Nicotine Tob Res. 2005;7: 533-540.
14. Hong SI, Hasche L, Bowland S. Structural relationships between social activities and longitudinal trajectories of depression among older adults. The Gerontologist. 2009;49: 1-11.
15. Brame B, Nagin DS, Tremblay RE. Developmental trajectories of physical aggression from school entry to late adolescence. J Child Psychol Psychiatry. 2001;42: 503-512.
16. Broidy LM, Nagin DS, Tremblay RE, et al. Developmental trajectories of childhood disruptive behaviors and adolescent delinquency: a six-site, cross-national study. Dev Psychol. 2003;39: 222-245.
17. Castellanos FX, Lee PP, Sharp W, et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attentiondeficit/ hyperactivity disorder. JAMA. 2002;288: 1740-1748.
18. Verkleij SPJ, Hoekstra T, Rozendaal RM, et al. Defining discriminative pain trajectories in hip osteoarthritis over a 2-year time period. Ann Rheum Dis. 2012;71: 1517-1523.
19. Walsh K, Danielson CK, McCauley J, et al. Longitudinal trajectories of posttraumatic stress disorder symptoms and binge drinking among adolescent girls: the role of sexual victimization. J Adolesc Health. 2012;50: 54-59.
20. Yeates KO, Taylor HG, Rusin J, et al. Longitudinal trajectories of postconcussive symptoms in children with mild traumatic brain injuries and their relationship to acute clinical status. Pediatrics. 2009;123: 735-743.
21. Riegel B. Predictors of objectively measured medication nonadherence in adults with heart failure. Circ Heart Fail. 2011;5: 430-436.
22. Twisk J, Hoekstra T. Classifying developmental trajectories over time should be done with great caution: a comparison between methods. J Clin Epidemiol. 2012;65: 1078-1087.
23. Choudhry NK, Fischer MA, Avorn J, et al. The implications of therapeutic complexity on adherence to cardiovascular medications. Arch Intern Med. 2011;171: 814-822.
24. Benner JS, Glynn RJ, Mogun H, et al. Long-term persistence in use of statin therapy in elderly patients. JAMA. 2002;288: 455-461.
25. Karve S, Cleves MA, Helm M, et al. Good and poor adherence: optimal cut-point for adherence measures using administrative claims data. Curr Med Res Opin. 2009;25: 2303-2310.
26. Shrank WH, Hoang T, Ettner SL, et al. The implications of choice: prescribing generic or preferred pharmaceuticals improves medication adherence for chronic conditions. Arch Intern Med. 2006; 166: 332-337.
27. Chan DC, Shrank WH, Cutler D, et al. Patient, physician, and payment predictors of statin adherence. Med Care. 2010;48: 196-202.
28. Choudhry NK, Shrank WH, Levin RL, et al. Measuring concurrent adherence to multiple related medications. Am J Manag Care. 2009; 15: 457-464.
29. Fischer MA, Choudhry NK, Brill G, et al. Trouble getting started: predictors of primary medication nonadherence. Am J Med. 2011; 124: 1081.e9-1081.e22.
30. Kulik A, Shrank WH, Levin R, et al. Adherence to statin therapy in elderly patients after hospitalization for coronary revascularization. Am J Cardiol. 2011;107: 1409-1414.
31. Setoguchi S, Choudhry N, Levin R, et al. Temporal trends in adherence to cardiovascular medications in elderly patients after hospitalization for heart failure. Clin Pharmacol Ther. 2010;88: 548-554.
32. Harrell F, Lee KL, Mark DB. Tutorial in biostatistics multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors. Stat Med. 1996;15: 361-387.
33. Schwarz G. Estimating the dimension of a model. Ann Stat. 1978;6: 461-464.
34. Jones BL, Nagin DS. Advances in group-based trajectory modeling and an SAS procedure for estimating them. Sociol Methods Res. 2007; 35: 542-571.
35. Liu X, Engel CC. Predicting longitudinal trajectories of health probabilities with random-effects multinomial logit regression. Stat Med. 2012;31: 4087-4101.
36. Muthén B. Latent variable analysis: growth mixture modeling and related techniques for longitudinal data. In: Kaplan D, ed. The Sage Handbook of Quantitative Methodology for the Social Sciences. Thousand Oaks, CA: Sage Publications; 2004: 345-368.
37. Hartigan JA, Wong MA. A k-means clustering algorithm. Appl Stat. 1979;28: 100-108.
38. McCutcheon AL. Latent Class Analysis. Newbury Park, CA: Sage Publications; 1987.