Mapping the Genetic Variation of Regional Brain Volumes as Explained by All Common SNPs from the ADNI Study

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Bryant, Christopher ^a   Giovanello, Kelly S ^b,c   Ibrahim, Joseph G ^a   Chang, Jing ^a   Shen, Dinggang ^c   Peterson, Bradley S ^d   Zhu, Hongtu ^a,c  

^a IL   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALZHEIMER DISEASE; APOE GENE; ARTICLE; AUTOSOME; BRAIN ASYMMETRY; BRAIN SIZE; CEREBROSPINAL FLUID; CLINICAL STUDY; CONTROLLED STUDY; COPY NUMBER VARIATION; FEMALE; GENE; GENE MAPPING; GENETIC DATABASE; GENETIC VARIABILITY; GENOTYPE; GRAY MATTER; HEMISPHERE; HUMAN; INTRACRANIAL VOLUME; LEFT HEMISPHERE; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; PATHOPHYSIOLOGY; PHENOTYPIC VARIATION; PROMOTER REGION; PUBLIC-PRIVATE PARTNERSHIP; RIGHT HEMISPHERE; SINGLE NUCLEOTIDE POLYMORPHISM; WHITE MATTER;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; ORGAN SIZE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84883193582     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071723     Document Type: Article

References (45)

1. Chen CH, Gutierrez ED, Thompson W, Panizzon MS, Jernigan TL, et al. (2012) Hierarchical genetic organization of human cortical surface area. Science 335 (6076) (): 1634-6 PubMed PMID:22461613.
2. Gilmore JH, Schmitt JE, Knickmeyer RC, Smith JK, Lin W, et al. (2010) Genetic and environmental contributions to neonatal brain structure: A twin study. Hum Brain Mapp ((8)) pp. 1174-82 PubMed PMID:20063301.
3. Yoon U, Perusse D, Lee JM, Evans AC, (2011) Genetic and environmental influences on structural variability of the brain in pediatric twin: deformation based morphometry. Neurosci Lett 493 (1-2) (): 8-13 PubMed PMID:21296128.
4. Hulshoff Pol HE, Schnack HG, Mandl RC, Brans RG, van Haren NE, et al. (2006) Gray and white matter density changes in monozygotic and same-sex dizygotic twins discordant for schizophrenia using voxel-based morphometry. Neuroimage ((2)) pp. 482-8 PubMed PMID:16497519.
5. Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, et al. (2012) Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet 44 (5) (): 539-44 PubMed PMID:22504418.
6. Biffi A, Anderson CD, Desikan RS, Sabuncu M, Cortellini L, et al. (2010) Genetic variation and neuroimaging measures in Alzheimer disease. Arch Neurol 67 (6) (): 677-85 PubMed PMID:20558387.
7. Erten-Lyons D, Jacobson A, Kramer P, Grupe A, Kaye J, (2010) The FAS gene, brain volume, and disease progression in Alzheimer's disease. Alzheimers Dement ((2)) pp. 118-24 PubMed PMID:19766542.
8. Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, et al. (2009) Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 18 (4) (): 767-78 PubMed PMID:19010793.
9. Inkster B, Strijbis EM, Vounou M, Kappos L, Radue EW, et al. (2013) Histone deacetylase gene variants predict brain volume changes in multiple sclerosis. Neurobiol Aging 34 (1) (): 238-47 PubMed PMID:22884548.
10. Strijbis EM, Inkster B, Vounou M, Naegelin Y, Kappos L, et al. (2012) Glutamate gene polymorphisms predict brain volumes in multiple sclerosis. Mult Scler 31PubMed PMID:22851457.
11. Kremen WS, Panizzon MS, Neale MC, Fennema-Notestine C, Prom-Wormley E, et al. (2012) Heritability of brain ventricle volume: converging evidence from inconsistent results. Neurobiol Aging 33 (1) (): 1-8 PubMed PMID:20363053.
12. Stein JL, Hua X, Morra JH, Lee S, Hibar DP, et al. (2010) Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease. Neuroimage 51 (2) (): 542-54 PubMed PMID:20197096.
13. Stein JL, Hua X, Lee S, Ho AJ, Leow AD, et al. (2010) Voxelwise genome-wide association study (vGWAS). Neuroimage 53 (3) (): 1160-74 PubMed PMID:20171287.
14. Hibar DP, Stein JL, Kohannim O, Jahanshad N, Saykin AJ, et al. (2011) Voxelwise gene-wide association study (vGeneWAS): multivariate gene-based association testing in 731 elderly subjects. Neuroimage 56 (4) (): 1875-91 PubMed PMID:21497199.
15. Shen L, Kim S, Risacher SL, Nho K, Swaminathan S, et al. (2010) Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. Neuroimage 53 (3) (): 1051-63 PubMed PMID:20100581.
16. Yang J, Manolio TA, Pasquale LR, Boerwinkle E, Caporaso N, et al. (2011) Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet 43 (6) ():: 519-25 PubMed PMID: 21552263.
17. Lee SH, Wray NR, Goddard ME, Visscher PM, (2011) Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 88 (3) ():: 294-305 PubMed PMID: 21376301.
18. Schellenberg GD, Montine TJ, (2012) The genetics and neuropathology of Alzheimer's disease. Acta Neuropathol 124 (3) (): 305-23 PubMed PMID:22618995.
19. Shen D, Davatzikos C, (2004) Measuring temporal morphological changes robustly in brain MR images via 4-dimensional template warping. NeuroImage 21 (4) ():: 1508-1517 PubMed PMID: 15050575.
20. Davatzikos C, Genc A, Xu D, Resnick SM, (2001) Voxel-based morphometry using the RAVENS maps: methods and validation using simulated longitudinal atrophy. Neuroimage 14 (6) (): 1361-9 PubMed PMID:11707092.
21. Goldszal AF, Davatzikos C, Pham DL, Yan MX, Bryan RN, et al. (1998) An image-processing system for qualitative and quantitative volumetric analysis of brain images. J Comput Assist Tomogr 22 (5) (): 827-37 PubMed PMID:9754125.
22. Kabani N, MacDonald D, Holmes C, Evans A, (1998) A 3D atlas of the human brain. Neuroimage 7: S717.
23. Yang J, Lee SH, Goddard ME, Visscher PM, (2011) GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 88 (1) (): 76-82 PubMed PMID:21167468.
24. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, et al. (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42 (7) ():: 565-9 PubMed PMID: 20562875.
25. Frey BJ, Dueck D, (2007) Clustering by passing messages between data points. Science 315 (5814) (): 972-6 PubMed PMID:17218491.
26. Bodenhofer U, Kothmeier A, Hochreiter S, (2011) APCluster: an R package for affinity propagation clustering. Bioinformatics 27 (17) (): 2463-4 PubMed PMID:21737437.
27. Carmelli D, DeCarli C, Swan GE, Jack LM, Reed T, et al. (1998) Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke 29 (6) (): 1177-81 PubMed PMID:9626291.
28. Pfefferbaum A, Sullivan EV, Swan GE, Carmelli D, (2000) Brain structure in men remains highly heritable in the seventh and eighth decades of life. Neurobiol Aging 21 (1) (): 63-74 PubMed PMID:10794850.
29. Kremen WS, Prom-Wormley E, Panizzon MS, Eyler LT, Fischl B, et al. (2010) Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study. Neuroimage 49 (2) (): 1213-23 PubMed PMID:19786105.
30. Peper JS, Brouwer RM, Boomsma DI, Kahn RS, Hulshoff Pol HE, (2007) Genetic influences on human brain structure: a review of brain imaging studies in twins. Hum Brain Mapp 28 (6) (): 464-73 PubMed PMID:17415783.
31. Tramo MJ, Loftus WC, Thomas CE, Green RL, Mott LA, et al. (1995) Surface Area of Human Cerebral Cortex and Its Gross Morphological Subdivisions: In Vivo Measurements in Monozygotic Twins Suggest Differential Hemisphere Effects of Genetic Factors. J Cogn Neurosci 7: 2, 292-302.
32. Wright IC, Sham P, Murray RM, Weinberger DR, Bullmore ET, (2002) Genetic contributions to regional variability in human brain structure: methods and preliminary results. Neuroimage 17 (1) (): 256-71 PubMed PMID:12482082.
33. Niskanen E, Könönen M, Määttä S, Hallikainen M, Kivipelto M, et al. (2011) New insights into Alzheimer's disease progression: a combined TMS and structural MRI study. PLoS One 6 (10) (): e26113 PubMed PMID:22022529.
34. Almeida OP, Burton EJ, McKeith I, Gholkar A, Burn D, et al. (2003) MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's disease. Dement Geriatr Cogn Disord 16 (2) (): 57-63 PubMed PMID:12784028.
35. Madsen SK, Ho AJ, Hua X, Saharan PS, Toga AW, et al. (2010) 3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects. Neurobiol Aging 31 (8) (): 1312-25 PubMed PMID:20538376.
36. Buckner RL, Andrews-Hanna JR, Schacter DL, (2008) The brain's default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci 1124: 1-38 PubMed PMID:18400922.
37. Raichle ME, Snyder AZ, (2007) A default mode of brain function: a brief history of an evolving idea. Neuroimage 37 (4) (): 1083-90; discussion 1097-9 PubMed PMID:17719799.
38. Buckner RL, Snyder AZ, Shannon BJ, LaRossa G, Sachs R, et al. (2005) Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 25 (34) (): 7709-17 PubMed PMID:16120771.
39. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, et al. (1997) Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 42 (1) (): 85-94 PubMed PMID:9225689.
40. Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, et al. (2002) Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 17 (1) (): 302-16 PubMed PMID:12482085.
41. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, et al. (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334 (12) (): 752-8 PubMed PMID:8592548.
42. Weyhenmeyer JA, Gallman EA (2007) Rapid Review of Neuroscience. Mosby Elsevier. p.102.
43. Chakravarthy VS, Joseph D, Bapi RS, (2010) What do the basal ganglia do? A modeling perspective. Biol Cybern 103 (3) (): 237-53 PubMed PMID:20644953.
44. Stocco A, Lebiere C, Anderson JR, (2010) Conditional routing of information to the cortex: a model of the basal ganglia's role in cognitive coordination. Psychol Rev 117 (2) (): 541-74 PubMed PMID:20438237.
45. Ungerlieder L, Mishkin M (1982) Two cortical visual systems. In D.JIngle, M.AGoodale, & R.JMansfield (Eds.), Analysis of Visual Behavior (pp. 549-580). Cambridge, MA: MIT Press.