A CCR6 variant strongly associated with rheumatoid arthritis in two populations is not associated with ankylosing spondylitis

Rheumatology International

Volumn 33, Issue 9, 2013, Pages 2443-2444

  Cohen, Carla J ^a   Karaderi, Tugce ^a   Pointon, Jennifer J ^a   Wordsworth, B Paul ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR6; INTERLEUKIN 23 RECEPTOR; STAT3 PROTEIN;

ANKYLOSING SPONDYLITIS; CROHN DISEASE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENOTYPE; HAPLOTYPE MAP; HELPER CELL; HEREDITY; HUMAN; LETTER; META ANALYSIS (TOPIC); PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; TH17 CELL;

ARTHRITIS, RHEUMATOID; CROHN DISEASE; GENE FREQUENCY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CCR6; SPONDYLITIS, ANKYLOSING;

EID: 84883149898     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-012-2404-6     Document Type: Letter

References (9)

1. Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP et al (2010) Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 42(6):508-514
2. Kochi Y, Okada Y, Suzuki A, Ikari K, Terao C, Takahashi A et al (2010) A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. Nat Genet 42(6):515-519
3. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD et al (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40(8):955-962
4. Karaderi T, Harvey D, Farrar C, Appleton LH, Stone MA, Sturrock RD et al (2009) Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series. Rheumatology 48(4):386-389
5. Danoy P, Pryce K, Hadler J, Bradbury LA, Farrar C, Pointon J et al (2010) Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet 6(12):e1001195
6. Australo-Anglo-American Spondyloarthritis Consortium (TASC) (2010) Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet 42:123-127
7. Williams IR (2004) Chemokine receptors and leukocyte trafficking in the mucosal immune system. Immunol Res 29(1-3):283-292
8. Hemdan NYA, Birkenmeier G, Wichmann G, Abu El-Saad AM, Krieger T, Conrad K et al (2010) Interleukin-17-producing T helper cells in autoimmunity. Autoimmun Rev 9(11):785-792
9. Romagnani S, Maggi E, Liotta F, Cosmi L, Annunziato F (2009) Properties and origin of human Th17 cells. Mol Immunol 47(1):3-7