Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumonia

Respiratory Research

Volumn 14, Issue 1, 2013, Pages

  Lemiale, Virginie ^a   Debrumetz, Alexandre ^a   Delannoy, Alexandra ^b   Alberti, Corinne ^b,c   Azoulay, Elie ^a,c  

^a SAINT LOUIS HOSPITAL   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Immunocompromised host; Mortality; Pneumocystis jiroveci infection

Indexed keywords

ANTINEOPLASTIC AGENT; FLUDARABINE; IMMUNOSUPPRESSIVE AGENT; PREDNISONE; STEROID; VASOACTIVE AGENT;

ADULT; AGED; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; ARTIFICIAL VENTILATION; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HEMATOLOGIC MALIGNANCY; HOSPITAL ADMISSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOXEMIA; IMMUNOSUPPRESSIVE TREATMENT; INTENSIVE CARE UNIT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MORTALITY; ORGAN TRANSPLANTATION; PNEUMOCYSTIS PNEUMONIA; PNEUMOTHORAX; RETROSPECTIVE STUDY; STEROID THERAPY; DOSE RESPONSE; MIDDLE AGED; PNEUMOCYSTIS JIROVECI; RISK FACTOR; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TREATMENT OUTCOME;

ADULT; AGED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; PNEUMOCYSTIS JIROVECII; PNEUMONIA, PNEUMOCYSTIS; PREDNISONE; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STEROIDS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84883131190     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-87     Document Type: Article

References (21)

1. Sepkowitz KA. Pneumocystis carinii pneumonia in patients without AIDS. Clin Infect Dis 1993, 17(Suppl 2):S416-S422.
2. Festic E, Gajic O, Limper AH, et al. Acute respiratory failure due to pneumocystis pneumonia in patients without human immunodeficiency virus infection: outcome and associated features. Chest 2005, 128(2):573-579. 10.1378/chest.128.2.573, 16100140.
3. Magne D, Angoulvant A, Botterel F, Bouges-Michel C, Bougnoux ME, Bouree P, Chochillon C, Cornet M, Dannaoui E, Fekkar A, Galeazzi G, Yera H, Sarfati C, Roux P. Pneumocystosis: a network survey in the Paris area 2003-2008. Eur J Clin Microbiol Infect Dis 2011, 30(5):673-675. 10.1007/s10096-010-1139-0, 21229281.
4. Azoulay E, Mokart D, Rabbat A, et al. Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: prospective multicenter data. Crit Care Med 2008, 36(1):100-107. 10.1097/01.CCM.0000295590.33145.C4, 18090351.
5. Bollée G, Sarfati C, Thiéry G, et al. Clinical picture of Pneumocystis jiroveci pneumonia in cancer patients. Chest 2007, 132(4):1305-1310. 10.1378/chest.07-0223, 17934116.
6. Gagnon S, Boota AM, Fischl MA, et al. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A double-blind, placebo-controlled trial. N Engl J Med 1990, 323(21):1444-1450. 10.1056/NEJM199011223232103, 2233916.
7. Bozzette SA, Sattler FR, Chiu J, et al. A controlled trial of early adjunctive treatment with corticosteroids for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. California Collaborative Treatment Group. N Engl J Med 1990, 323(21):1451-1457. 10.1056/NEJM199011223232104, 2233917.
8. Pareja JG, Garland R, Koziel H. Use of adjunctive corticosteroids in severe adult non-HIV Pneumocystis carinii pneumonia. Chest 1998, 113(5):1215-1224. 10.1378/chest.113.5.1215, 9596297.
9. Delclaux C, Zahar JR, Amraoui G, et al. Corticosteroids as adjunctive therapy for severe Pneumocystis carinii pneumonia in non-human immunodeficiency virus-infected patients: retrospective study of 31 patients. Clin Infect Dis 1999, 29(3):670-672. 10.1086/598651, 10530464.
10. Zahar JR, Robin M, Azoulay E, et al. Pneumocystis carinii pneumonia in critically ill patients with malignancy: a descriptive study. Clin Infect Dis 2002, 35(8):929-934. 10.1086/342338, 12355379.
11. Monnet X, Vidal-Petiot E, Osman D, et al. Critical care management and outcome of severe Pneumocystis pneumonia in patients with and without HIV infection. Crit Care 2008, 12(1):R28. 10.1186/cc6806, 2374632, 18304356.
12. Kovacs JA, Hiemenz JW, Macher AM, et al. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med 1984, 100(5):663-671. 10.7326/0003-4819-100-5-663, 6231873.
13. Limper AH, Offord KP, Smith TF, et al. Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS. Am Rev Respir Dis 1989, 140(5):1204-1209. 10.1164/ajrccm/140.5.1204, 2817582.
14. Azoulay E, Parrot A, Flahault A, Cesari D, Lecomte I, Roux P, Saidi F, Fartoukh M, Bernaudin JF, Cadranel J, Mayaud C. AIDS-related Pneumocystis carinii pneumonia in the era of adjunctive steroids: implication of BAL neutrophilia. Am J Respir Crit Care Med 1999, 160(2):493-499. 10.1164/ajrccm.160.2.9901019, 10430719.
15. Jacobs JA, Dieleman MM, Cornelissen EI, Groen EA, Wagenaar SS, Drent M. Bronchoalveolar lavage fluid cytology in patients with Pneumocystis carinii pneumonia. Acta Cytol 2001, 45(3):317-326. 10.1159/000327625, 11393061.
16. Moon SM, Kim T, Sung H, Kim. Outcomes of mild-to-severe Pneumocystis pneumonia treated with adjunctive steroid in non-HIV-infected patients. Antimicrob Agents Chemother 2011, 55(10):4613-4618. 10.1128/AAC.00669-11, 3186978, 21788460.
17. Peigne V, Rusinová K, Karlin L, et al. Continued survival gains in recent years among critically ill myeloma patients. Intensive Care Med 2009, 35(3):512-518. 10.1007/s00134-008-1320-4, 18853139.
18. Kim T, Moon SM, Sung H. Outcomes of non-HIV-infected patients with Pneumocystis pneumonia and concomitant pulmonary cytomegalovirus infection. Scand J Infect Dis 2012, 44(9):670-677. 10.3109/00365548.2011.652665, 22264016.
19. Wang EH, Partovi N, Levy RD. Pneumocystis pneumonia in solid organ transplant recipients: not yet an infection of the past. Transpl Infect Dis 2012, 14(5):519-525. 10.1111/j.1399-3062.2012.00740.x, 22571389.
20. De Castro N, Neuville S, Sarfati C. Ribaud et al. Occurrence of Pneumocystis jiroveci pneumonia after allogeneic stem cell transplantation: a 6-year retrospective study. Bone Marrow Transpl 2005, 36(10):879-883.
21. Pène F, Percheron S, Lemiale V, et al. Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit. Crit Care Med 2008, 36(3):690-696. 10.1097/CCM.0B013E318165314B, 18431262.