LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition

Nature Communications

Volumn 4, Issue , 2013, Pages

  Jin, Jing ^a,b   Yu, Qian ^b   Han, Chaofeng ^b   Hu, Xiang ^c   Xu, Sheng ^b   Wang, Qingqing ^a   Wang, Jianli ^a   Li, Nan ^b   Cao, Xuetao ^a,b,c  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LRRFIP2 PROTEIN; NLRP3 INFLAMMASOME; PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID; HORMONE; INHIBITION; MOLECULAR ANALYSIS; PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; EXPRESSION VECTOR; FEMALE; FLOW CYTOMETRY; GENE SILENCING; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PERITONITIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; RNA INTERFERENCE; TANDEM MASS SPECTROMETRY;

ANIMALS; CARRIER PROTEINS; CASPASE 1; CASPASE INHIBITORS; CELLS, CULTURED; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; FEMALE; INFLAMMASOMES; MACROPHAGES; MICE; MICE, INBRED C57BL; PERITONITIS; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS;

EID: 84883127402     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3075     Document Type: Article

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