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Volumn 8, Issue 9, 2013, Pages 1457-1461

Strategic targeting of multiple water-mediated interactions: A concise and rational structure-based design approach to potent and selective MMP-13 inhibitors

(2) Fischer, Thomas a Riedl, Rainer a

a ZURICH UNIVERSITY OF APPLIED SCIENCES (Switzerland)

Author keywords

Chemical biology; Matrix metalloproteinase inhibitors; Structure activity relationships; Structure based drug design; Water mediated interactions

Indexed keywords

COLLAGENASE 3 INHIBITOR; COLLAGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

CHEMICAL BIOLOGY; MATRIX METALLOPROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIPS; STRUCTURE-BASED DRUG DESIGN; WATER-MEDIATED INTERACTIONS;

BINDING SITES; DRUG DESIGN; HYDROGEN BONDING; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE INHIBITORS; PHTHALIMIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 84883055699 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201300278 Document Type: Article

Times cited : (18)

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