A multicentre randomised trial comparing weekly paclitaxel + S-1 with weekly paclitaxel + 5-fluorouracil for patients with advanced gastric cancer

European Journal of Cancer

Volumn 49, Issue 14, 2013, Pages 2995-3002

  Huang, Dingzhi ^a,b   Ba, Yi ^a   Xiong, Jianping ^c   Xu, Nong ^d   Yan, Zhao ^a   Zhuang, Zhixiang ^e   Yu, Zhuang ^f   Wan, Huiping ^g   Zhang, Yang ^h   Deng, Ting ^a   Zheng, Rongsheng ⁱ   Guo, Zengqing ^j   Hu, Chunhong ^k   Wang, Meiling ^l   Yu, Zhonghe ^m   Yao, Yang ⁿ   Meng, Jichang ^o  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b KEY LABORATORY OF CANCER PREVENTION AND THERAPY   (China)

^c NANCHANG UNIVERSITY   (China)

^d ZHEJIANG UNIVERSITY   (China)

^e THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^f QINGDAO UNIVERSITY   (China)

^g People's Hospital of Jiangxi Province   (China)

^h DALIAN MEDICAL UNIVERSITY   (China)

ⁱ BENGBU MEDICAL COLLEGE   (China)

^j FUJIAN PROVINCIAL TUMOR HOSPITAL   (China)

^k Department of Oncology   (China)

^l SHANGHAI JIAO TONG UNIVERSITY   (China)

^m CHINESE PLA GENERAL HOSPITAL   (China)

ⁿ SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^o Department of Oncology   (China)

more..

Author keywords

Efficacy; Gastric cancer; Paclitaxel; S 1; Safety

Indexed keywords

FLUOROURACIL; FOLINIC ACID; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; PACLITAXEL;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANEMIA; ANOREXIA; ARTICLE; CANCER CONTROL; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL PROTOCOL; CONSTIPATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DIARRHEA; DISEASE CONTROL RATE; DIZZINESS; DRUG EFFICACY; DRUG FEVER; DRUG SAFETY; DRUG TREATMENT FAILURE; FATIGUE; FEMALE; GASTROINTESTINAL DISEASE; HEMATOLOGIC DISEASE; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; MEDICAL PARAMETERS; MULTICENTER STUDY; NAUSEA; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RANDOMIZED CONTROLLED TRIAL; SENSORY NEUROPATHY; STOMACH CANCER; TREATMENT OUTCOME; VOMITING;

EFFICACY; GASTRIC CANCER; PACLITAXEL; S-1; SAFETY;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; ANOREXIA; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; FLUOROURACIL; HUMANS; INFUSIONS, INTRAVENOUS; KAPLAN-MEIER ESTIMATE; LEUCOVORIN; LEUKOPENIA; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NAUSEA; OXONIC ACID; PACLITAXEL; STOMACH NEOPLASMS; TEGAFUR; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84883055254     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.05.021     Document Type: Article

References (24)

1. H. Brenner, D. Rothenbacher, and V. Arndt Epidemiology of stomach cancer Methods Mol Biol 472 2009 467 477
2. A. Jemal, R. Siegel, and J. Xu Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
3. E. Van Cutsem, V.M. Moiseyenko, and S. Tjulandin Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group J Clin Oncol 24 2006 4991 4997
4. D. Cunningham, N. Starling, and S. Rao Capecitabine and oxaliplatin for advanced esophagogastric cancer N Engl J Med 358 2008 36 46
5. W. Koizumi, H. Narahara, and T. Hara S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial Lancet Oncol 9 2008 215 221
6. J.A. Ajani, J. Fairweather, and P. Dumas Phase II study of taxol in patients with advanced gastric carcinoma Cancer J Sci Am 4 1998 269 274
7. S. Cascinu, F. Graziano, and N. Cardarelli Phase II study of paclitaxel in pretreated advanced gastric cancer Anticancer Drugs 9 1998 307 310
8. D. Mavroudis, C. Kourousis, and N. Androulakis Frontline treatment of advanced gastric cancer with docetaxel and granulocyte colony-stimulating factor (G-CSF): a phase II trial Am J Clin Oncol 23 2000 341 344
9. Y.J. Bang, W.K. Kang, and Y.K. Kang Docetaxel 75 mg/m(2) is active and well tolerated in patients with metastatic or recurrent gastric cancer: a phase II trial Jpn J Clin Oncol 32 2002 248 254
10. Y. Kodera, M. Fujiwara, and H. Yokoyama Combination of oral fluoropyrimidine and docetaxel: reappraisal of synergistic effect against gastric carcinoma xenografts In Vivo 19 2005 861 866
11. Y. Kano, M. Akutsu, and S. Tsunoda Schedule-dependent interaction between paclitaxel and 5-fluorouracil in human carcinoma cell lines in vitro Br J Cancer 74 1996 704 710
12. S. Maeda, T. Sugiura, and Y. Saikawa Docetaxel enhances the cytotoxicity of cisplatin to gastric cancer cells by modification of intracellular platinum metabolism Cancer Sci 5 2004 679 684
13. P.A. Vasey, G.C. Jayson, and A. Gordon Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma J Natl Cancer Inst 96 2004 1682 1691
14. Y. Hsu, A.K. Sood, and J.I. Sorosky Docetaxel versus paclitaxel for adjuvant treatment of ovarian cancer: case-control analysis of toxicity Am J Clin Oncol 27 2004 14 18
15. S.H. Park, W.K. Lee, and M. Chung Paclitaxel versus docetaxel for advanced gastric cancer: a randomized phase II trial in combination with infusional 5-fluorouracil Anticancer Drugs 17 2006 225 229
16. Q. Sun, C. Liu, and H. Zhong Multi-center phase II trial of weekly paclitaxel plus cisplatin combination chemotherapy in patients with advanced gastric and gastro-esophageal cancer Jpn J Clin Oncol 39 2009 237 243
17. N. Nagata, M. Kimura, and N. Hirabayashi Phase II study of weekly paclitaxel and cisplatin combination therapy for advanced or recurrent gastric cancer Hepatogastroenterology 55 2008 1846 1850
18. N. Boku, S. Yamamoto, and H. Fukuda Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study Lancet Oncol 10 2009 1063 1069
19. H. Narahara, K. Fujitani, and H. Takiuchi Phase II study of a combination of S-1 and paclitaxel in patients with unresectable or metastatic gastric cancer Oncology 74 2008 37 41
20. H.J. Kang, H.M. Chang, and T.W. Kim A phase II study of paclitaxel and capecitabine as a first-line combination chemotherapy for advanced gastric cancer Br J Cancer 98 2008 316 322
21. Y. Ueda, H. Yamagishi, and D. Ichikawa Multicenter phase II study of weekly paclitaxel plus S-1 combination chemotherapy in patients with advanced gastric cancer Gastric Cancer 13 2010 149 154
22. E. Mochiki, K. Ogata, and T. Ohno Phase II multi-institutional prospective randomised trial comparing S-1+paclitaxel with S-1+cisplatin in patients with unresectable and/or recurrent advanced gastric cancer Br J Cancer 107 2012 31 36
23. Y.H. Kim, W. Koizumi, and K.H. Lee Randomized phase III study of S-1 alone versus S-1 plus docetaxel (DOC) in the treatment for advanced gastric cancer (AGC): the START trial J Clin Oncol 29 2011 7 (meeting abstract)
24. K. Yoshida, M. Fujii, and W. Koizumi S-1 plus docetaxel versus S-1 for advanced gastric cancer (START trial) update 2012 (JACCRO and KCSG study group) Ann Oncol 23 Suppl. 9 2012 19 (meeting abstract)