Slow increase in IgG avidity correlates with prevention of human cytomegalovirus transmission to the fetus

Journal of Medical Virology

Volumn 85, Issue 11, 2013, Pages 1960-1967

  Furione, Milena ^a   Rognoni, Vanina ^a   Sarasini, Antonella ^a   Zavattoni, Maurizio ^a   Lilleri, Daniele ^a   Gerna, Giuseppe ^a   Revello, Maria Grazia ^a,b  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b Fondazione Carlo Denegri   (Italy)

Author keywords

Congenital HCMV infection; IgG avidity; Pregnancy

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; UREA;

ADULT; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; HUMAN; INTRAUTERINE INFECTION; MAJOR CLINICAL STUDY; PREGNANT WOMAN; PRIMARY INFECTION; RETROSPECTIVE STUDY; SOLID; VERTICAL TRANSMISSION;

HUMAN HERPESVIRUS 5;

CONGENITAL HCMV INFECTION; IGG AVIDITY; PREGNANCY;

ADOLESCENT; ADULT; ANTIBODIES, VIRAL; ANTIBODY AFFINITY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; IMMUNOGLOBULIN G; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; YOUNG ADULT;

EID: 84883050611     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.23691     Document Type: Article

References (19)

1. Alford CA, Hayes K, Britt W. 1988. Primary cytomegalovirus infection in pregnancy: Comparison of antibody responses to virus-encoded proteins between women with and without intrauterine infection. J Infect Dis 158:917-924.
2. Cannon MJ, Davis KF. 2005. Washing our hands of the congenital cytomegalovirus disease epidemic. BMC Public Health 5:70.
3. de Vries JJC, Vossen ACTM, Kroes ACM, van der Zeijst BAM. 2011. Implementing neonatal screening for congenital cytomegalovirus: Addressing the deafness of policy makers. Rev Med Virol 21:54-61.
4. Gerna G, Cereda PM, Cattaneo E, Achilli G, Revello MG. 1978. Immunoglobulin G to virus-specific early antigens in congenital, primary, and reactivated human cytomegalovirus infections. Infect Immun 22:833-841.
5. Gerna G, Revello MG, Percivalle E, Zavattoni M, Parea M, Battaglia M. 1990. Quantification of human cytomegalovirus viremia by using monoclonal antibodies to different viral proteins. J Clin Microbiol 28:2681-2688.
6. Gerna G, Sarasini A, Patrone M, Percivalle E, Fiorina L, Campanini G, Gallina A, Baldanti F, Revello MG. 2008. Human cytomegalovirus serum neutralizing antibodies block virus infection of endothelial/epithelial cells, but not fibroblasts, early during primary infection. J Gen Virol 89:853-865.
7. Hayes K, Alford C, Britt W. 1987. Antibody response to virus-encoded proteins after cytomegalovirus mononucleosis. J Infect Dis 156:615-621.
8. Kenneson A, Cannon MJ. 2007. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol 17:253-276.
9. Lilleri D, Kabanova A, Lanzavecchia A, Gerna G. 2012. Antibodies against neutralization epitopes of human cytomegalovirus gH/gL/pUL128-130-131 complex and virus spreading may correlate with virus control in vivo. J Clin Immunol 32:1324-1331.
10. Lilleri D, Kabanova A, Revello MG, Percivalle E, Sarasini A, Genini E, Sallusto F, Lanzavecchia A, Corti D, Gerna G. 2013. Fetal cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131. PLoS ONE 8:e59863.
11. Maidji E, McDonagh S, Genbacev O, Tabato T, Pereira L. 2006. Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis. Am J Pathol 168:1210-1226.
12. Nigro G, Adler SP, La Torre R, Best AM. 2005. Passive immunization during pregnancy for congenital cytomegalovirus infection. N Engl J Med 353:1350-1362.
13. Revello MG, Gerna G. 2004. Pathogenesis and prenatal diagnosis of human cytomegalovirus infection. J Clin Virol 29:71-83.
14. Revello MG, Percivalle E, Zannino M, Rossi V, Gerna G. 1991. Development and evaluation of a capture ELISA for IgM antibody to the human cytomegalovirus major DNA binding protein. J Virol Methods 35:315-329.
15. Revello MG, Zavattoni M, Furione M, Baldanti F, Gerna G. 1999. Quantification of human cytomegalovirus DNA in amniotic fluid of mothers of congenitally infected fetuses. J Clin Microbiol 37:3350-3352.
16. Revello MG, Zavattoni M, Furione M, Lilleri D, Gorini G, Gerna G. 2002. Diagnosis and outcome of preconceptional and periconceptional primary human cytomegalovirus infection. J Infect Dis 186:553-557.
17. Revello MG, Genini E, Gorini G, Klercy C, Piralla A, Gerna G. 2010. Comparative evaluation of eight commercial human citomegalovirus IgG avidity assays. J Clin Virol 48:255-259.
18. Revello MG, Fabbri E, Furione M, Zavattoni M, Lilleri D, Tassis B, Quarenghi A, Cena C, Arossa A, Montanari L, Rognoni V, Spinillo A, Gerna G. 2011. Role of prenatal diagnosis and counseling in the management of 735 pregnancies complicated by primary human citomegalovirus infection: A 20-year experience. J Clin Virol 50:303-307.
19. Stagno S, Reynolds DW, Smith RJ. 1978. Use of isolated nuclei in the indirect fluorescent-antibody test for human cytomegalovirus infection: Comparison with microneutralization, anticomplement, and conventional indirect fluorescent-antibody assay. J Clin Microbiol 7:486-489.