Bronchial Thermoplasty. A Novel Therapy for Severe Asthma.

Clinics in Chest Medicine

Volumn 34, Issue 3, 2013, Pages 437-444

  Sheshadri, Ajay ^a   Castro, Mario ^a   Chen, Alexander ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Airway remodeling; Airway smooth muscle; Bronchial thermoplasty; Severe asthma

Indexed keywords

BECLOMETASONE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CORTICOSTEROID; LONG ACTING DRUG; PREDNISONE;

ASTHMA; BREATHING MUSCLE; BRONCHIAL THERMOPLASTY; BRONCHOSCOPE; BRONCHOSCOPY; BRONCHOSPASM; CATHETER; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG MEGADOSE; DRUG TREATMENT FAILURE; EQUIPMENT DESIGN; EVIDENCE BASED MEDICINE; HUMAN; INFLAMMATION; LUNG CANCER; LUNG RESECTION; MODERATE PERSISTENT ASTHMA; PRIORITY JOURNAL; RADIOFREQUENCY; REVIEW; SEVERE PERSISTENT ASTHMA; SMOOTH MUSCLE; SPIROMETRY; SYMPTOM; THERAPY EFFECT;

AIRWAY REMODELING; AIRWAY SMOOTH MUSCLE; BRONCHIAL THERMOPLASTY; SEVERE ASTHMA;

ADULT; ASTHMA; BRONCHI; BRONCHOSCOPY; CATHETER ABLATION; HUMANS;

EID: 84883050074     PISSN: 02725231     EISSN: 15578216     Source Type: Journal    
DOI: 10.1016/j.ccm.2013.03.003     Document Type: Review

References (31)

1. Akinbami L.J., Moorman J.E., Bailey C., et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010. NCHS Data Brief 2012, 94. Available at:, Accessed August 10, 2012. http://www.cdc.gov/nchs/data/databriefs/db94.pdf.
2. Barnett S.B., Nurmagambetov T.A. Costs of Asthma in the United States: 2002-2007. JAllergy Clin Immunol 2011, 127:145-152.
3. Akinbami LJ, Moorman JE, Liu X. Asthma prevalence, health care use, and mortality: United States, 2005-2009. National Health Statistics Report 2011; No. 32. Available at: Accessed August 10, 2012. http://www.cdc.gov/nchs/data/nhsr/nhsr032.pdf.
4. Lange P., Parner J., Vestbo J., et al. A15-year follow-up study of ventilatory function in adults with asthma. NEngl J Med 1998, 339:1194-1200.
5. O'Byrne P.M., Pederson S., Lamm C.J., et al. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med 2009, 179:19-24.
6. Bai T.R., Vonk J.M., Postma D.S., et al. Severe exacerbations predict lung function decline in asthma. Eur Respir J 2007, 30:452-456.
7. Moore W.C., Bleecker E.R., Curran-Evveret D., et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. JAllergy Clin Immunol 2007, 119:405-413.
8. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000, 162:2341-2351.
9. Panettieri R.A., Kotlikoff M.I., Gerthoffer W.T., et al. Airway smooth muscle in bronchial tone, inflammation, and remodeling. Am J Respir Crit Care Med 2008, 177:248-252.
10. Ebina M., Takahashi T., Chiba T., et al. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma: a 3-D morphometric study. Am Rev Respir Dis 1993, 148:720-726.
11. James A.L., Elliot J.G., Jones R.L., et al. Airway smooth muscle hypertrophy and hyperplasia in asthma. Am J Respir Crit Care Med 2012, 185:1058-1064.
12. Fernando H.C., De Hoyos A., Landreneau R.J., et al. Radiofrequency ablation for the treatment of non-small cell lung cancer in marginal surgical candidates. JThorac Cardiovasc Surg 2005, 129:639-644.
13. Bruix J., Sherman M. Management of hepatocellular carcinoma. Hepatology 2005, 42:1208-1236.
14. Benussi S., Nascimbene S., Calori G., et al. Surgical ablation of atrial fibrillation with a novel bipolar radiofrequency device. JThorac Cardiovasc Surg 2005, 130:491-497.
15. Danek C.J., Lombard C.M., Dungworth D.L., et al. Reduction of airway hyperresponsiveness to methacholine by the application of RF energy in dogs. JAppl Physiol 2004, 97:1946-1953.
16. Dryda P., Tazzeo T., DoHarris L., et al. Acute response of airway muscle to extreme temperature induces disruption of actin-myosin interaction. Am J Respir Cell Mol Biol 2011, 44:213-221.
17. Despas P.J., Leroux M., Macklem P.T. Site of airway obstruction as determined by measuring maximal expiratory flow breathing air and a helium-oxygen mixture. JClin Invest 1975, 55:1090-1099.
18. Mayse M.L., Laviolette M., Rubin A.S., et al. Clinical pearls for bronchial thermoplasty. JBronchol 2007, 14:115-123.
19. Castro M., Rubin A.S., Laviolette M., et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multi-center, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med 2010, 181:116-124.
20. Banyai A. The middle lobe syndrome and its quasi-variants. Chest 1974, 65:135.
21. Miller J.D., Cox G., Vincic L., et al. Aprospective feasibilty study of bronchial thermoplasty in the human airway. Chest 2005, 127:1999-2006.
22. Cox G., Miller J.D., McWilliams A., et al. Bronchial thermoplasty for asthma. Am J Respir Crit Care Med 2006, 173:965-969.
23. Cox G., Thomson N.C., Rubin A.S., et al. Asthma control during the year after bronchial thermoplasty. NEngl J Med 2007, 356:1327-1337.
24. Pavord I.D., Cox G., Thomson N.C., et al. Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med 2007, 176:1185-1191.
25. Linde K., Streng A., Jürgen S., et al. Acupuncture for patients with migraine: a randomized controlled trial. JAMA 2005, 293:2118-2125.
26. Leon M.B., Kornowski R., Downey W.E., et al. Ablinded, randomized placebo-controlled trial of percutaneous laser myocardial revascularization to improve angina symptoms in patients with severe coronary disease. JAm Coll Cardiol 2005, 46:1812-1819.
27. Cox G., Laviolette M., Rubin A., et al. Long term safety of bronchial thermoplasty (BT): 3 year data from multiple studies. Am J Respir Crit Care Med 2009, 179:A2780.
28. Cox G., Laviolette M., Rubin A., et al. 5-year safety of bronchial thermoplasty demonstrated in patients with moderate to severe asthma: Asthma Intervention Research (AIR) trial. Am J Respir Crit Care Med 2010, 181:A6839.
29. Thomson N.C., Rubin A.S., Niven R.M., et al. Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial. BMC Pulm Med 2011, 11:8.
30. Pavord I. 5-year safety of bronchial thermoplasty demonstrated in patients with severe refractory asthma: Research in Severe Asthma (RISA) trial. Am J Respir Crit Care Med 2011, 183:A6382.
31. Castro M., Rubin A.S., Laviolette M., et al. Two-year persistence of fffect of bronchial thermoplasty (BT) in patients with severe asthma: AIR2 trial. Chest 2010, 138:768A.