A clinicopathological study of resected small-sized squamous cell carcinomas of the peripheral lung: Prognostic significance of serum carcinoembryonic antigen levels

Annals of Thoracic and Cardiovascular Surgery

Volumn 19, Issue 5, 2013, Pages 351-357

  Nagashima, Takuya ^a   Sakao, Yukinori ^a   Mun, Mingyon ^a   Ishikawa, Yuichi ^a   Nakagawa, Ken ^a   Masuda, Munetaka ^b   Okumura, Sakae ^a  

^a CANCER INSTITUTE HOSPITAL   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Carcinoembryonic antigen; Lung cancer; Squamous cell cancer

Indexed keywords

CARCINOEMBRYONIC ANTIGEN;

AGE; AGED; ARTICLE; BLOOD; CHI SQUARE DISTRIBUTION; DISEASE FREE SURVIVAL; FEMALE; HUMAN; KAPLAN MEIER METHOD; LUNG RESECTION; LUNG TUMOR; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MALE; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; RISK FACTOR; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; TIME; TREATMENT OUTCOME; TUMOR VOLUME; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; CARCINOEMBRYONIC ANTIGEN; CARCINOMA, SQUAMOUS CELL; CHI-SQUARE DISTRIBUTION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PNEUMONECTOMY; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL RATE; TIME FACTORS; TREATMENT OUTCOME; TUMOR BURDEN;

EID: 84883030884     PISSN: 13411098     EISSN: 21861005     Source Type: Journal    
DOI: 10.5761/atcs.oa.12.01843     Document Type: Article

References (28)

1. Hammer SP, Petrovichev N, Carvalho L, Brambilla C, Matsuno Y, et al. Squamous cell carcinoma. In: Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC eds.; World Health Organization classification of tumors. Pathology and genetics of tumors of lung, pleura, thymus and heart. Lyon: IARC Press, 2004; pp 26-30.
2. Asamura H, Nakayama H, Kondo H, et al. Lymph node involvement, recurrence, and prognosis in resected small, peripheral, non-small-cell lung carcinomas: are these carcinomas candidates for video-assisted lobectomy? J Thorac Cardiovasc Surg 1996; 111: 1125-1134.
3. Funai K, Yokose T, Ishii G, et al. Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung. Am J Surg Pathol 2003; 27: 978-984.
4. Sakurai H, Asamura H, Watanabe S, et al. Clinicopathologic features of peripheral squamous cell carcinoma of the lung. Ann Thorac Surg 2004; 78: 222-227.
5. Maeshima AM, Maeshima A, Asamura H, et al. Histologic prognostic factors for small-sized squamous cell carcinomas of the peripheral lung. Lung Cancer 2006; 52: 53-58.
6. Yousem SA. Peripheral squamous cell carcinoma of lung: patterns of growth with particular focus on airspace filling. Hum Pathol 2009; 40: 861-867.
7. Ou SH, Zell JA, Ziogas A, et al. Prognostic factors for survival of stage I nonsmall cell lung cancer patients: a population-based analysis of 19,702 stage I patients in the California Cancer Registry from 1989 to 2003. Cancer 2007; 110: 1532-1541.
8. León-Atance P, Moreno-Mata N, González-Aragoneses F, et al. Multicenter analysis of survival and prognostic factors in pathologic stage I non-small-cell lung cancer according to the new 2009 TNM classification. Arch Bronconeumol 2011; 47: 441-446 (in English, Spanish).
9. Mostertz W, Stevenson M, Acharya C, et al. Age- and sex-specific genomic profiles in non-small cell lung cancer. JAMA 2010; 303: 535-543.
10. Shimada H, Nabeya Y, Okazumi S, et al. Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. Surgery 2003; 133: 486-494.
11. Kosugi S, Nishimaki T, Kanda T, et al. Clinical significance of serum carcinoembryonic antigen, carbohydrate antigen 19-9, and squamous cell carcinoma antigen levels in esophageal cancer patients. World J Surg 2004; 28: 680-685.
12. Chen SW, Liang JA, Hung YC, et al. Clinical implications of elevated pretreatment carcinoembryonic antigen in patients with advanced squamous cell carcinoma of the uterine cervix. Tumour Biol 2008; 29: 255-261.
13. Büntzel J, Hornig A, Glatzel M, et al. Tumor markers and lymphatic metastasis in head and neck cancer patients. Anticancer Res 2005; 25: 1539-1542.
14. Kandiloros D, Eleftheriadou A, Chalastras T, et al. Prospective study of a panel of tumor markers as prognostic factors in patients with squamous cell carcinoma of head and neck. Med Oncol 2006; 23: 463-470.
15. Krimmel M, Hoffmann J, Krimmel C, et al. Relevance of SCC-Ag, CEA, CA 19.9 and CA 125 for diagnosis and follow-up in oral cancer. J Craniomaxillofac Surg 1998; 26: 243-248.
16. Costey M, Mora J, León X, et al. CEA and Cyfra 21.1 study pre-treatment in 252 patients with head and neck carcinomas. Acta Otorrinolaringol Esp 2004; 55: 338-342. (in Spanish)
17. Tas F, Aydiner A, Topuz E, et al. Utility of the serum tumor markers: CYFRA 21.1, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCC) in squamous cell lung cancer. J Exp Clin Cancer Res 2000; 19: 477-481.
18. Kulpa J, Wójcik E, Reinfuss M, et al. Carcinoembryonic antigen, squamous cell carcinoma antigen, CYFRA 21-1, and neuron-specific enolase in squamous cell lung cancer patients. Clin Chem 2002; 48: 1931-1937.
19. Tomita M, Matsuzaki Y, Edagawa M, et al. Prognostic significance of preoperative serum carcinoembryonic antigen level in lung adenocarcinoma but not squamous cell carcinoma. Ann Thorac Cardiovasc Surg 2004; 10: 76-80.
20. Body JJ, Sculier JP, Raymakers N, et al. Evaluation of squamous cell carcinoma antigen as a new marker for lung cancer. Cancer 1990; 65: 1552-1556.
21. Huhti E, Saloheimo M, Sutinen S, et al. Does the location of lung cancer affect its prognosis? Eur J Respir Dis 1983; 64: 460-465.
22. Matsuguma H, Nakahara R, Igarashi S, et al. Pathologic stage I non-small cell lung cancer with high levels of preoperative serum carcinoembryonic antigen: clinicopathologic characteristics and prognosis. J Thorac Cardiovasc Surg 2008; 135: 44-49.
23. Inoue M, Minami M, Shiono H, et al. Clinicopathologic study of resected, peripheral, small-sized, nonsmall cell lung cancer tumors of 2 cm or less in diameter: pleural invasion and increase of serum carcinoembryonic antigen level as predictors of nodal involvement. J Thorac Cardiovasc Surg 2006; 131: 988-993.
24. Okada M, Nishio W, Sakamoto T, et al. Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease. Ann Thorac Surg 2004; 78: 216-221.
25. Sakao Y, Sakuragi T, Natsuaki M, et al. Clinicopathological analysis of prognostic factors in clinical IA peripheral adenocarcinoma of the lung. Ann Thorac Surg 2003; 75: 1113-1117.
26. Veronesi G, Pelosi G, Sonzogni A, et al. Tumour CEA as predictor of better outcome in squamous cell carcinoma of the lung. Lung Cancer 2005; 48: 233-240.
27. Okamura A, Ohkawa J, Fujisawa H, et al. Clinicopathological study on the relationship between serum-CEA and tissue-CEA of resected lung cancer cases. Acta Pathol Jpn 1984; 34: 1209-1219.
28. Saijo T, Ishii G, Nagai K, et al. Differences in clinicopathological and biological features between centraltype and peripheral-type squamous cell carcinoma of the lung. Lung Cancer 2006; 52: 37-45.