Effects of humidity and solution viscosity on electrospun fiber morphology

Tissue Engineering - Part C: Methods

Volumn 19, Issue 10, 2013, Pages 810-819

  Nezarati, Roya M ^a   Eifert, Michelle B ^a   Cosgriff Hernandez, Elizabeth ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC HUMIDITY; DEGRADATION; ELECTROSPINNING; ELECTROSTATIC DEVICES; ELECTROSTATIC DISCHARGE; MECHANICAL PROPERTIES; MORPHOLOGY; PHASE SEPARATION; POLYCAPROLACTONE; POLYETHYLENE GLYCOLS; POLYMERS; SCAFFOLDS (BIOLOGY); SCANNING ELECTRON MICROSCOPY; VAPORS; VISCOSITY;

ENVIRONMENTAL PARAMETER; HIGH RELATIVE HUMIDITIES; LOW RELATIVE HUMIDITIES; POLYCARBONATE URETHANE; SOLUTION PARAMETERS; SOLVENT VOLATILITY; TISSUE ENGINEERING SCAFFOLD; VAPOR-INDUCED PHASE SEPARATION;

FIBERS;

MACROGOL; POLYCAPROLACTONE; URETHAN DERIVATIVE; WATER;

ARTICLE; CHEMICAL STRUCTURE; CONDUCTANCE; CONTACT ANGLE; DIELECTRIC CONSTANT; ELECTROSPINNING; FLOW KINETICS; FLOW RATE; HUMIDITY; HYDROPHOBICITY; MISCIBILITY; MOLECULAR MECHANICS; MOLECULAR WEIGHT; PHASE SEPARATION; PHYSICAL PARAMETERS; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STATIC ELECTRICITY; SURFACE PROPERTY; TISSUE ENGINEERING; VISCOSITY; VOLATILITY; WATER ABSORPTION;

HUMIDITY; MICROSCOPY, ELECTRON, SCANNING; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; POLYURETHANES; SOLUTIONS; TISSUE ENGINEERING; VISCOSITY;

EID: 84883025854     PISSN: 19373384     EISSN: 19373392     Source Type: Journal    
DOI: 10.1089/ten.tec.2012.0671     Document Type: Article

References (71)

1. Reneker, D., and Chun, I. Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology 7, 216, 1996.
2. Hohman, M., Shin, M., Rutledge, G., and Brenner, M. Electrospinning and electrically forced jets. I. Stability theory. Phys Fluids 13, 2201, 2001.
3. Shin, Y.M., Hohman, M.M., Brenner, M.P., and Rutledge, G.C. Electrospinning: a whipping fluid jet generates submicron polymer fibers. Appl Phys Lett 78, 1149, 2001.
4. Doshi, J., and Reneker, D.H. Electrospinning process and applications of electrospun fibers. J Electrost 35, 151, 1995.
5. Lee, K., Kim, H., Ryu, Y., Kim, K., and Choi, S. Mechanical behavior of electrospun fiber mats of poly(vinyl chloride)/ polyurethane polyblends. J Polym Sci Part B Polym Phys 41, 1256, 2003.
6. Tan, E.P.S., Ng, S.Y., and Lim, C.T. Tensile testing of a single ultrafine polymeric fiber. Biomaterials 26, 1453, 2005.
7. Wong, S.-C., Baji, A., and Leng, S. Effect of fiber diameter on tensile properties of electrospun poly(e-caprolactone). Polymer 49, 4713, 2008.
8. Stylianopoulos, T., Bashur, C., Goldstein, A., Guelcher, S.A., and Barocas, V. Computational predictions of the tensile properties of electrospun fibre meshes: Effect of fibre diameter and fibre orientation. J Mech Behav Biomed Mater 1, 326, 2008.
9. Kim, K., Yu, M., Zong, X., Chiu, J., Fang, D., Seo, Y.-S., Hsiao, B.S., Chu, B., and Hadjiargyrou, M. Control of degradation rate and hydrophilicity in electrospun non-woven poly(d,l-lactide) nanofiber scaffolds for biomedical applications. Biomaterials 24, 4977, 2003.
10. Bolgen, N., Menceloglu, Y., Acatay, K., Vargel, I., and Piskin, E. In vitro and in vivo degradation of non-woven materials made of poly(e-caprolactone) nanofibers prepared by electrospinning under different conditions. J Biomater Sci Polymer Edn 16, 1537, 2005.
11. Yang, F., Murugan, R., Wang, S., and Ramakrishna, S. Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 26, 2603, 2005.
12. Chew, S., Mi, R., Hoke, A., and Leong, K. The effect of the alignment of electrospun fibrous scaffolds on Schwann cell maturation. Biomaterials 29, 653, 2008.
13. Keun Kwon, I., Kidoaki, S., and Matsuda, T. Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential. Biomaterials 26, 3929, 2005.
14. Baiguera, S., del Gaudio, C., Fioravanzo, L., Bianco, A., Grigioni, M., and Folin, M. In vitro astrocyte and cerebral endothelial cell response to electrospun poly(e-caprolactone) mats of different architecture. J Mater Sci Mater Med 21, 1353, 2010.
15. Gupta, D., Venugopal, J., Prabhakaran, M., Dev, V., Low, S., Choon, A., and Ramakrishna, S. Aligned and random nanofibrous substrate for the in vitro culture of Schwann cells for neural tissue engineering. Acta Biomater 5, 2560, 2009.
16. Xu, C., Inai, R., Kotaki, M., and Ramakrishna, S. Electrospun nanofiber fabrication as synthetic extracellular matrix and its potential for vascular tissue engineering. Tissue Eng 10, 1160, 2004.
17. Soletti, L., Hong, Y., Guan, J., Stankus, J., El-Kurdi, M., Wagner, W., and Vorp, D. A bilayered elastomeric scaffold for tissue engineering of small diameter vascular grafts. Acta Biomater 6, 110, 2010.
18. Hong, Y., Ye, S., Nienponice, A., Soletti, L., Vorp, D., and Wagner, W. A small diameter, fibrous vascular conduit generated from a poly(ester urethane)urea and a phospholipid polymer blend. Biomaterials 30, 2457, 2009.
19. Bini, T., Gao, S., Tan, T., Wang, S., Lim, A., Hai, L., and Ramakrishna, S. Electrospun poly(L-lactide-co-glycolide) biodegradable polymer nanofibre tubes for peripheral nerve regeneration. Nanotechnology 15, 1459, 2004.
20. Ghasemi-Mobarakeh, L., Prabhakaran, M., Morshed, M., Nasr-Esfahani, M., and Ramakrishna, S. Electrospun poly(ecaprolactone)/ gelatin nanofibrous scaffolds for nerve tissue enginering. Biomaterials 29, 4532, 2008.
21. Prabhakaran, M., Venugopal, J., Chyan, T., Hai, L., Chan, C., Lim, A., and Ramakrishna, S. Electrospun biocomposite nanofibrous scaffolds for neural tissue engineering. Tissue Eng Part A 14, 1787, 2008.
22. Kumbar, S.G., Nukavarapu, S.P., James, R., Nair, L.S., and Laurencin, C.T. Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering. Biomaterials 29, 4100, 2008.
23. Zhu, X., Cui, W., Li, X., and Jin, Y. Electrospun fibrous mats with high porosity as potential scaffolds for skin tissue engineering. Biomacromolecules 9, 1795, 2008.
24. Khil, M., Cha, D., Kim, H., Kim, I., and Bhattarai, N. Electrospun nanofibrous polyurethane membrane as wound dressing. J Biomed Mater Res Part B 67B, 675, 2003.
25. Yoshimoto, H., Shin, Y., Terai, H., and Vacanti, J. A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials 24, 2077, 2003.
26. Li, C., Vepari, C., Jin, H.-J., Kim, H.J., and Kaplan, D.L. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 27, 3115, 2006.
27. Jarusuwannapoom, T., Hongrojjanawiwat, W., Jitjaicham, S., Wannatong, L., Nithitanakul, M., Pattamaprom, C., Koombhongse, P., Rangkupan, R., and Supaphol, P. Effect of solvents on electro-spinnability of polystyrene solutions and morphological appearance of resulting electrospun polystyrene fibers. Eur Polym J 41, 409, 2005.
28. Ki, C.S., Baek, D.H., Gang, K.D., Lee, K.H., Um, I.C., and Park, Y.H. Characterization of gelatin nanofiber prepared from gelatin-formic acid solution. Polymer 46, 5094, 2005.
29. Geng, X., Kwon, O., and Jang, J. Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials 26, 5427, 2005.
30. Zong, X., Kim, K., Fang, D., Ran, S., Hsiao, B., and Chu, B. Structure and process relationship of electrospun bioabsorbable nanofiber membranes. Polymer 43, 4403, 2002.
31. Deitzel, J., Kleinmeyer, J., Harris, D., and Tan, N. The effect of processing variables on the morphology of electrospun nanofibers and textiles. Polymer 42, 261, 2001.
32. Katti, D.S., Robinson, K.W., Ko, F.K., and Laurencin, C.T. Bioresorbable nanofiber-based systems for wound healing and drug delivery: optimization of fabrication parameters. J Biomed Mater Res Part B 70B, 286, 2004.
33. Lee, J.S., Choi, K.H., Ghim, H.D., Kim, S.S., Chun, D.H., Kim, H.Y., and Lyoo, W.S. Role of molecular weight of atactic poly(vinyl alcohol) (PVA) in the structure and properties of PVA nanofabric prepared by electrospinning. J Appl Polym Sci 93, 1638, 2004.
34. Buchko, C.J., Chen, L.C., Shen, Y., and Martin, D.C. Processing and microstructural characterization of porous biocompatible protein polymer thin films. Polymer 40, 7397, 1999.
35. Lee, K., Kim, H., La, Y., Lee, D., and Sung, N. Influence of a mixing solvent with tetrahydrofuran and N,N-dimethylformamide on electrospun poly(vinyl chloride) nonwoven mats. J Polym Sci Part B Polym Phys 40, 2259, 2002.
36. Yuan, X., Zhang, Y., Dong, C., and Sheng, J. Morphology of ultrafine polysulfone fibers prepared by electrospinning. Polym Int 53, 1704, 2004.
37. Jeun, J., Lim, Y., and Nho, Y. Study on morphology of electrospun poly(caprolactone) nanofiber. J Ind Eng Chem 11, 573, 2005.
38. Zhang, C., Yuan, X., Wu, L., Han, Y., and Sheng, J. Study on morphology of electrospun poly(vinyl alcohol) mats. Eur Polym J 41, 423, 2005.
39. Zuo, W., Zhu, M., Yang, W., Yu, H., Chen, Y., and Zhang, Y. Experimental study on relationship between jet instability and formation of beaded fibers during electrospinning. Polym Eng Sci 45, 704, 2005.
40. Wannatong, L., Sirivat, A., and Supaphol, P. Effects of solvents on electrospun polymeric fibers: preliminary study on polystyrene. Polym Int 53, 1851, 2004.
41. Koski, A., Yim, K., and Shivkumar, S. Effect of molecular weight on fibrous PVA produced by electrospinning. Mater Lett 58, 493, 2004.
42. Tao, J., and Shivkumar, S. Molecular weight dependent structural regimes during the electrospinning of PVA. Mater Lett 61, 2325, 2007.
43. Duan, B., Dong, C., Yuan, X., and Yao, K. Electrospinning of chitosan solutions in acetic acid with poly(ethylene oxide). J Biomater Sci Polym Ed 15, 797, 2004.
44. Kim, H., Kim, K., Jin, H., and Chin, I. Morphological characterization of electrospun nano-fibrous membranes of biodegradable poly(L-lactide) and poly(lactide-co-glycolide). Macromol Symp 224, 145, 2005.
45. Zhao, Z., Li, J., Yuan, X., Li, X., Zhang, Y., and Sheng, J. Preparation and properties of electrospun poly(vinylidene fluoride) membranes. J Appl Polym Sci 97, 466, 2005.
46. Gupta, P., Elkins, C., Long, T.E., and Wilkes, G.L. Electrospinning of linear homopolymers of poly(methyl methacrylate): exploring relationships between fiber formation, viscosity, molecular weight and concentration in a good solvent. Polymer 46, 4799, 2005.
47. Mit-uppatham, C., Nithitanakul, M., and Supaphol, P. Ultrafine electrospun polyamide-6 fibers: effect of solution conditions on morphology and average fiber diameter. Macromol Chem Phys 205, 2327, 2004.
48. Jiang, H., Fang, D., Hsiao, B.S., Chu, B., and Chen, W. Optimization and characterization of dextran membranes prepared by electrospinning. Biomacromolecules 5, 326, 2004.
49. Son, W., Youk, J., Lee, T., and Park, W. The effects of solution properties and polyelectrolyte on electrospinning of ultrafine poly(ethylene oxide) fibers. Polymer 45, 2959, 2004.
50. Fong, H., Chun, I., and Reneker, D. Beaded nanofibers formed during electrospinning. Polymer 40, 4585, 1999.
51. Kenawy, E.R., Layman, J.M., Watkins, J.R., Bowlin, G.L., J.A., M., Simpson, D.G., and Wnek, G.E. Electrospinning of poly(ethylene-co-vinyl alcohol) fibers. Biomaterials 24, 907, 2003.
52. McKee, M., Wilkes, G., Colby, R., and Long, T. Correlations of solution rheology with electrospun fiber formation of linear and branched polyesters. Macromolecules 37, 1760, 2004.
53. Ryu, Y., Kim, H., Lee, K., Park, H., and Lee, D. Transport properties of electrospun nylon 6 nonwoven mats. Eur Polym J 39, 1883, 2003.
54. Cha, D., Kim, H., Lee, K., Jung, Y., Cho, J., and Chun, B. Electrospun nonwovens of shape-memory polyurethane block copolymers. J Appl Polym Sci 96, 460, 2005.
55. Tong, H., and Wang, M. Electrospinning of fibrous polymer scaffolds using positive voltage or negative voltage: a comparative study. Biomed Mater 5, 1, 2010.
56. Ding, B., Kim, H.-Y., Lee, S.-C., Shao, C.-L., Lee, D.-R., Park, S.-J., Kwag, G.-B., and Choi, K.-J. Preparation and characterization of a nanoscale poly(vinyl alcohol) fiber aggregate produced by an electrospinning method. J Polym Sci Part B Polym Phys 40, 1261, 2002.
57. Huang, L., Nagapudi, K., Apkarian, R.P., and Chaikof, E.L. Engineered collagen-PEO nanofibers and fabrics. J Biomater Sci Polym Ed 12, 979, 2001.
58. Guarino, V., Cirillo, V., Taddei, P., Alvarez-Perez, M.A., and Ambrosio, L. Tuning size scale and crystallinity of PCL electrospun fibres via solvent permittivity to address hMSC response. Macromol Biosci 11, 1694, 2011.
59. Li, D., and Xia, Y. Electrospinning of nanofibers: reinventing the wheel? Adv Mater 16, 1151, 2004.
60. Megelski, S., Stephens, J.S., Chase, D.B., and Rabolt, J.F. Micro- and nanostructured surface morphology on electrospun polymer fibers. Macromolecules 35, 8456, 2002.
61. Demir, M., Yilgor, I., Yilgor, E., and Erman, B. Electrospinning of polyurethane fibers. Polymer 43, 3303, 2002.
62. Medeiros, E.S., Mattoso, L.H.C., Offeman, R.D., Wood, D.F., and Orts, W.J. Effect of relative humidity on the morphology of electrospun polymer fibers. Can J Chem 86, 590, 2008.
63. Huang, L., Bui, N.-N., Manickam, S.S., and McCutcheon, J.R. Controlling electrospun nanofiber morphology and mechanical properties using humidity. J Polym Sci Part B Polym Phys 49, 1734, 2011.
64. Hardick, O., Stevens, B., and Bracewell, D. Nanofibre fabrication in a temperature and humidity controlled environment for improved fibre consistency. J Mater Sci 46, 3890, 2011.
65. Kim, G.T., Lee, J.S., Shin, J.H., Ahn, Y.C., Hwang, Y.J., Shin, H.S., Lee, J.K., and Sung, C.M. Investigation of pore formation for polystyrene electrospun fiber: effect of relative humidity. Korean J Chem Eng 22, 783, 2005.
66. Peresin, M.S., Habibi, Y., Vesterinen, A.-H., Rojas, O.J., Pawlak, J.J., and Seppä lä , J.V. Effect of moisture on electrospun nanofiber composites of poly(vinyl alcohol) and cellulose nanocrystals. Biomacromolecules 11, 2471, 2010.
67. Kalayci, V., Patra, P., Kim, Y., Ugbolue, S., and Warner, S. Charge consequences in electrospun polyacrylonitrile (PAN) nanofibers. Polymer 46, 7191, 2005.
68. Lin, J., Ding, B., Yu, J., and Hsieh, Y. Direct fabrication of highly nanoporous polystyrene fibers via electrospinning. ACS Appl Mater Interfaces 2, 521, 2010.
69. Zheng, J., Zhang, H., Zhao, Z., and Han, C.C. Construction of hierarchical structures by electrospinning or electrospraying. Polymer 53, 546, 2012.
70. Casper, C.L., Stephens, J.S., Tassi, N.G., Chase, D.B., and Rabolt, J.F. Controlling surface morphology of electrospun polystyrene fibers: effect of humidity and molecular weight in the electrospinning process. Macromolecules 37, 573, 2003.
71. Pai, C.-L., Boyce, M.C., and Rutledge, G.C. Morphology of porous and wrinkled fibers of polystyrene electrospun from dimethylformamide. Macromolecules 42, 2102, 2009.