Block of gap junctions eliminates aberrant activity and restores light responses during retinal degeneration

Journal of Neuroscience

Volumn 33, Issue 35, 2013, Pages 13972-13977

  Toychiev, Abduqodir H ^a   Ivanova, Elena ^a   Yee, Christopher W ^a   Sagdullaev, Botir T ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MECLOFENAMIC ACID;

ANIMAL TISSUE; ARTICLE; BURST FORMING UNIT; CONTROLLED STUDY; ELECTRICAL SYNAPSE; ELECTROPHYSIOLOGY; GAP JUNCTION; MOUSE; NERVE POTENTIAL; NERVE STIMULATION; NEUROTRANSMISSION; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; RETINA DEGENERATION; RETINA GANGLION CELL; SIGNAL TRANSDUCTION; SPIKE WAVE; SYNAPTIC POTENTIAL; VISUAL IMPAIRMENT; VISUAL STIMULATION;

ACTION POTENTIALS; ANIMALS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6; EXCITATORY POSTSYNAPTIC POTENTIALS; GAP JUNCTIONS; LIGHT; LIGHT SIGNAL TRANSDUCTION; MECLOFENAMIC ACID; MICE; MICE, TRANSGENIC; PHOTORECEPTOR CELLS; RETINAL DEGENERATION; RETINAL GANGLION CELLS; VISION, OCULAR;

EID: 84883001947     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2399-13.2013     Document Type: Article

References (20)

1. Bloomfield SA, Völgyi B (2009) The diverse functional roles and regulation of neuronal gap junctions in the retina. Nat Rev Neurosci 10: 495-506. CrossRef Medline
2. Borowska J, Trenholm S, Awatramani GB (2011) An intrinsic neural oscillator in the degenerating mouse retina. J Neurosci 31:5000-5012. CrossRef Medline
3. Busskamp V, Duebel J, Balya D, Fradot M, Viney TJ, Siegert S, Groner AC, Cabuy E, Forster V, Seeliger M, Biel M, Humphries P, Paques M, Mohand-Said S, Trono D, Deisseroth K, Sahel JA, Picaud S, Roska B (2010) Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 329:413-417. CrossRef Medline
4. Deans MR, Volgyi B, Goodenough DA, Bloomfield SA, Paul DL (2002) Connexin36 is essential for transmission of rod-mediated visual signals in the mammalian retina. Neuron 36:703-712. CrossRef Medline
5. Freeman DK, Rizzo JF 3rd, Fried SI (2011) Encoding visual information in retinal ganglion cells with prosthetic stimulation. J Neural Eng 8:035005. CrossRef Medline
6. Gargini C, Terzibasi E, Mazzoni F, Strettoi E (2007) Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study. J Comp Neurol 500:222-238. CrossRef Medline
7. Hartong DT, Berson EL, Dryja TP (2006) Retinitis pigmentosa. Lancet 368: 1795-1809. CrossRef Medline
8. Jones BW, Kondo M, Terasaki H, Lin Y, McCall M, Marc RE (2012) Retinal remodeling. Jpn J Ophthalmol 56:289-306. CrossRef Medline
9. Lin B, Masland RH, Strettoi E (2009) Remodeling of cone photoreceptor cells after rod degeneration in rd mice. Exp Eye Res 88:589-599. CrossRef Medline
10. Margolis DJ, Newkirk G, Euler T, Detwiler PB (2008) Functional stability of retinal ganglion cells after degeneration-induced changes in synaptic input. J Neurosci 28:6526-6536. CrossRef Medline
11. Menzler J, Zeck G (2011) Network oscillations in rod-degenerated mouse retinas. J Neurosci 31:2280-2291. CrossRef Medline
12. Pan F, Mills SL, Massey SC (2007) Screening of gap junction antagonists on dye coupling in the rabbit retina. Vis Neurosci 24:609-618. CrossRef Medline
13. Sahel JA, Roska B (2013) Gene therapy for blindness. Annu Rev Neurosci 36:467-488. CrossRef Medline
14. Sampath AP, Rieke F (2004) Selective transmission of single photon responses by saturation at the rod-to-rod bipolar synapse. Neuron 41:431-443. CrossRef Medline
15. Stasheff SF, Shankar M, Andrews MP (2011) Developmental time course distinguishes changes in spontaneous and light-evoked retinal ganglion cell activity in rd1 and rd10 mice. J Neurophysiol 105:3002-3009. CrossRef Medline
16. Thyagarajan S, van Wyk M, Lehmann K, Löwel S, Feng G, Wässle H (2010) Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci 30:8745-8758. CrossRef Medline
17. Toychiev AH, Sagdullaev B, Yee CW, Ivanova E, Sagdullaev BT (2013) A time and cost efficient approach to functional and structural assessment of living neuronal tissue. J Neurosci Methods 214:105-112. CrossRef Medline
18. + channels. J Physiol 590: 2501-2517. CrossRef Medline
19. Veruki ML, Hartveit E (2009) Meclofenamic acid blocks electrical synapses of retinal AII amacrine and on-cone bipolar cells. J Neurophysiol 101: 2339-2347. CrossRef Medline
20. Yee CW, Toychiev AH, Sagdullaev BT (2012) Network deficiency exacerbates impairment in a mouse model of retinal degeneration. Front Syst Neurosci 6:8. CrossRef Medline