Cellular pathology of neurodegenerative disorders

Clinical Neurology

Volumn 53, Issue 8, 2013, Pages 609-617

  Wakabayashi, Koichi ^a  

^a HIROSAKI UNIVERSITY   (Japan)

Author keywords

Glial cell; Inclusion body; Neurodegenerative disease; Pathology; Peripheral nervous system

Indexed keywords

ALPHA SYNUCLEIN; TAU PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; CELL INCLUSION; CENTRAL NERVOUS SYSTEM; DEGENERATIVE DISEASE; FRONTOTEMPORAL DEMENTIA; GLIA; LEWY BODY; MOLECULAR MECHANICS; PERIPHERAL NERVOUS SYSTEM; PROTEIN AGGREGATION; REVIEW; SHY DRAGER SYNDROME; TAUOPATHY;

HISTOCYTOCHEMISTRY; HUMANS; NEURODEGENERATIVE DISEASES; PERIPHERAL NERVOUS SYSTEM; SYNUCLEINS; TAUOPATHIES; TDP-43 PROTEINOPATHIES;

EID: 84882969680     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: 10.5692/clinicalneurol.53.609     Document Type: Review

References (61)

1. den Hartog Jager WA, Bethlem J. The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans. J Neurol Neurosurg Psychiatry 1960;23:283-290.
2. Couchie D, Charriere-Bertrand C, Nunez J. Expression of the mRNA for tau proteins during brain development and in cultured neurons and astroglial cells. J Neurochem 1988; 50:1894-1899.
3. Muler R, Heinrich M, Heck S, et al. Expression of microtubule-associated protein MAP2 and tau in cultured rat brain oligodendrocytes. Cell Tissue Res 1997;288:239-249.
4. Ihara Y, Nukina N, Miura R, et al. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease. J Biochem (Tokyo) 1986;99:1807-1810.
5. Poorkaj R Bird TD, Wijsman E, et al. Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol 1998; 43:815-825.
6. Spillantini MG, Schmidt ML, Lee VM-Y, et al. a-Synuclein in Lewy bodies. Nature 1997;388:839-840.
7. Baba M, Nakajo S, et al. Aggregation of a-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 1998;152:879-884.
8. Wakabayashi K, Yoshimoto M, Tsuji S, et al. a-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 1998;249:180-182.
9. Fujiwara H, Hasegawa M, Dohmae N, et al. a-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biol 2002;4:160-164.
10. Nishie M, Mori F Fujiwara H, et al. Accumulation of phosphorylated a-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol 2004;107:292-298.
11. Mori F, Nishie M, Kakita A, et al. Relationship among alpha-synuclein accumulation, dopamine synthesis, and neuro-degeneration in Parkinson disease substantia nigra. J Neuropathol Exp Neurol 2006;65:808-815.
12. Nishie M, Mori F, Yoshimoto M, et al. A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy. Neuropathol Appl Neurobiol 2004;30:546-554.
13. Wakabayashi K, Tanji K, Odagiri S, et al. The Lewy body in Parkinson's disease and related neurodegenerative disorders. Mol Neurobiol 2012 May 24. [Epub ahead of print]
14. Wakabayashi K, Takahashi H. Cellular pathology in multiple system atrophy. Neuropathology 2006;26:338-345.
15. Takahashi H, Ohama E, Ikuta E Are Bunina bodies of endoplasmic reticulum origin? An ultrastructural study of subthalamic eosinophilic inclusions in a case of atypical motor neuron disease. Acta Pathol Jpn 1991;41:889-894.
16. Okamoto K, Mizuno Y, Fujita Y. Bunina bodies in amyotrophic lateral sclerosis. Neuropathology 2008;28:109-115.
17. Piao YS, Wakabayashi K, Kakita A, et al. Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000. Brain Pathol 2003;13:10-22.
18. Leigh PN, Anderton BH, Dodson A, et al. Ubiquitin deposits in anterior horn cells in motor neurone disease. Neurosci Lett 1988;93:197-203.
19. Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006;314:130-133.
20. Arai T, Hasegawa M, Akiyama H, et al. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 2006;351:602-611.
21. Mori F, Tanji K, Zhang HX, et al. Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia. Acta Neuropathol 2008; 116:193-203.
22. Nishihira Y, Tan CF Onodera O, et al. Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions. Acta Neuropathol 2008;116:169-182.
23. Miki Y, Mori F, Nunomura J, et al. Sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration: a TDP-43 immunohistochemical study. Neuropathology 2010;30:149-153.
24. Nishihira Y, Tan CE Toyoshima Y, et al. Sporadic amyotrophic lateral sclerosis: Widespread multisystem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator. Neuropathology 2009;29:689-696.
25. Nishihira Y, Tan CE Hoshi Y, et al. Sporadic amyotrophic lateral sclerosis of long duration is associated with relatively mild TDP-43 pathology. Acta Neuropathol 2009;117:45-53.
26. Kosaka T, Fu YJ, Shiga A, et al. Primary lateral sclerosis: upper-motor-predominant amyotrophic lateral sclerosis with frontotemporal lobar degeneration - immunohistochemical and biochemical analyses of TDP-43. Neuropathology 2012;32:373-384.
27. Hasegawa M, Arai T, Nonaka T, et al. Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann Neurol 2008;64:60-70.
28. Graham JG, Oppenheimer DR. Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry 1969;32:28-34.
29. Päpp MI, Kahn JE, Lantos PL. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sei 1989;94:79-100.
30. Nakazato Y, Yamazaki H, Hirato J, et al. Oligodendroglial microtubular tangles in multiple system atrophy. J Neuropathol Exp Neurol 1990;49:521-530.
31. Fujishiro H, Ahn TB, Frigerio R, et al. Glial cytoplasmic inclusions in neurologically normal elderly: prodromal multiple system atrophy? Acta Neuropathol 2008;116:269-275.
32. Kikuchi A, Takeda A, Okamura N, et al. In vivo visualization of a-synuclein deposition by carbon-ll-labelled 2-[2-(2-dimethylaminothiazol-5-yl) ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography in multiple system atrophy. Brain 2010;133:1772-1778.
33. Komori T, Arai N, Oda M, et al. Astrocytic plaques and tufts of abnormal fibers do not coexist in corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol 1998; 96:401-408.
34. Higuchi M, Zhang B, Forman MS, et al. Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. J Neuroscience 2005;25:9434-9443.
35. Dabir DY Robinson MB, Swanson E, et al. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. J Neuroscience 2006;26:644-654.
36. Kosaka K, Iseki E. Recent advances in dementia research in Japan: Non-Alzheimer-type degenerative dementias. Psychiatry Clin Neurosci 1998;52:367-373.
37. Croisier E, Graeber MB. Glial degeneration and reactive gliosis in alpha-synucleinopathies: the emerging concept of primary gliodegeneration. Acta Neuropathol 2006;112:517-530.
38. Wakabayashi K, Mori F, Tanji K, et al. Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain. Acta Neuropathol 2010;120:1-12.
39. den Hartog Jager WA, Bethlem J. The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans. J Neurol Neurosurg Psychiatry 1960;23:283-290.
40. Qualman SJ, Haupt HM, Yang R et al. Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease. Gastroenterology 1984;87:848-856.
41. Wakabayashi K, Takahashi H, Takeda S, et al. Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses. Acta Neuropathol 1988;76:217-221.
42. Wakabayashi K, Takahashi H. Neuropathology of autonomic nervous system in Parkinson's disease. Eur Neurol 1997; 38(suppl 2):2-7.
43. Orimo S, Takahashi A, Uchihara T, et al. Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease. Brain Pathol 2007;17:24-30.
44. Orimo S, Uchihara T, Nakamura A, et al. Axonal a-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease. Brain 2008;131:642-650.
45. Fumimura Y, Ikemura M, Saito Y, et al. Analysis of the adrenal gland is useful for evaluating pathology of the peripheral autonomic nervous system in Lewy body disease. J Neuropathol Exp Neurol 2007;66:354-362.
46. Del Tredici K, Hawkes CH, Ghebremedhin E, et al. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease. Acta Neuropathol 2010;119:703-707.
47. Ikemura M, Saito Y, Sengoku R, et al. Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol 2008; 67:945-953.
48. Miki Y, Tomiyama M, Ueno T, et al. Clinical availability of skin biopsy in the diagnosis of Parkinson's disease. Neurosci Lett 2010;469:357-359.
49. Braak H, Sastre M, Bohl JRE, et al. Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol 2007;113:421-429.
50. Pouclet H, Lebouvier T, Coron E, et al. Analysis of colonic alpha-synuclein pathology in multiple system atrophy. Parkinsonism Relat Disord 2012;18:893-895.
51. Orimo S, Kanazawa T, Nakamura A, et al. Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. Acta Neuropathol 2007;113:81-86.
52. Sone M, Yoshida M, Hashizume Y, et al. a-Synuclein-immuno-reactive structure formation is enhanced in sympathetic ganglia of patients with multiple system atrophy. Acta Neuropathol 2005;110:19-26.
53. Jellinger KA. More frequent Lewy bodies but less frequent Alzheimer-type lesions in multiple system atrophy as compared to age-matched control brains. Acta Neuropathol 2007;114:299-303.
54. Braak H, Del Tredici K, Rüb U, et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24:197-211.
55. Miki Y, Mori F, Wakabayashi K, et al. Incidental Lewy body disease restricted to the heart and stellate ganglia. Mov Disord 2009;24:2299-2301.
56. Braak H, Rüb U, Gai WR et al. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 2003;110:517-536.
57. Braak H, de Vos RAI, Bohl J, et al. Gastric a-synuclein immuno-reactive inclusions in Meissners and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006;396:67-72.
58. Funabe S, Takao M, Saito Y, et al. Neuropathology analysis of Lewy-related a-synucleinopathy in olfactory mucosa. Neuropathology 2013;33:47-58.
59. Li JY, Englund E, Holton JL, et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 2008;14:501-503.
60. Kordower JH, Chu Y, Hauser RA, et al. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008;14:504-506.
61. Lee SJ, Desplats P, Sigurdson C, et al. Cell-to-cell transmission of non-prion protein aggregates. Nat Rev Neurol 2010;6:702-706.