Rapid LC-MS drug metabolite profiling using bioreactor particles

Methods in Molecular Biology

Volumn 987, Issue , 2013, Pages 129-134

  Zhao, Linlin ^a   Bajrami, Besnik ^a   Rusling, James F ^a,b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Cytochrome P450; High throughput; LC MS MS; Magnetic separation; Metabolism; Sample preparation

Indexed keywords

DNA; DRUG METABOLITE; MAGNETIC NANOPARTICLE; MICROSOME ENZYME; 2,4 THIAZOLIDINEDIONE DERIVATIVE; CHROMAN DERIVATIVE; DICLOFENAC; DRUG; TROGLITAZONE;

ANIMAL CELL; ARTICLE; BIOREACTOR; DNA ADDUCT; DNA DAMAGE; DRUG ANALYSIS; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; REACTION TIME; ANIMAL; METABOLISM; METHODOLOGY; MICROSOME; TANDEM MASS SPECTROMETRY; TIME;

ANIMALS; BIOREACTORS; CHROMANS; CHROMATOGRAPHY, LIQUID; DICLOFENAC; HUMANS; MICROSOMES; PHARMACEUTICAL PREPARATIONS; RATS; TANDEM MASS SPECTROMETRY; THIAZOLIDINEDIONES; TIME FACTORS;

EID: 84882935214     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-321-3_11     Document Type: Article

References (3)

1. Bajrami B, Zhao L, Schenkman JB, Rusling JF (2009) Rapid LC-MS drug metabolite pro filing using microsomal enzyme bioreactors in a parallel processing format. Anal Chem 81: 9921-9929
2. Bajrami B, Hvastkovs EG, Jensen GC, Schenkman JB, Rusling JF (2008) Enzyme-DNA biocolloids for DNA adduct and reactive metabolite detection by chromatography-mass spectrometry. Anal Chem 80:922-932
3. Zhao L, Schenkman JB, Rusling JF (2010) High-throughput metabolic toxicity screening using magnetic biocolloid reactors and LC-MS/MS. Anal Chem 82:10172-10178