Exosome-enclosed microRNAs in exhaled breath hold potential for biomarker discovery in patients with pulmonary diseases

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 1, 2013, Pages

  Sinha, Anirban ^a   Yadav, Amit Kumar ^a   Chakraborty, Samarpana ^a   Kabra, S K ^b   Lodha, R ^b   Kumar, Manish ^a   Kulshreshtha, Ankur ^a   Sethi, Tavpritesh ^a   Pandey, Rajesh ^a   Malik, Gaurav ^a   Laddha, Saurabh ^a   Mukhopadhyay, Arijit ^a   Dash, Debasis ^a   Ghosh, Balaram ^a   Agrawal, Anurag ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; MICRORNA; RNA INDUCED SILENCING COMPLEX; TRANSCRIPTION FACTOR PAX7;

AIRWAY; ALGORITHM; ASTHMA; BREATHING; DNA SYNTHESIS; EPITHELIUM CELL; EXHALATION; EXOSOME; GENE EXPRESSION PROFILING; HUMAN; LETTER; LUNG ALVEOLUS EPITHELIUM; LUNG BIOPSY; LUNG DISEASE; LUNG TUBERCULOSIS; MEMBRANE VESICLE; NOSE MUCOSA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS;

EID: 84882885522     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.03.035     Document Type: Article

References (9)

1. Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA. MicroRNAs in body fluids-the mix of hormones and biomarkers. Nat Rev Clin Oncol 2011;8:467-77.
2. Jung M, Schaefer A, Steiner I, Kempkensteffen C, Stephan C, Erbersdobler A, et al. Robust microRNA stability in degraded RNA preparations from human tissue and cell samples. Clin Chem 2010;56:998-1006.
3. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-medi-ated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007;9:654-9.
4. Sinha A, Krishnan V, Sethi T, Roy S, Ghosh B, Lodha R, et al. Metabolomic signatures in nuclear magnetic resonance spectra of exhaled breath condensate identify asthma. Eur Respir J 2012;39:500-2.
5. Horvath I, Hunt J, Barnes PJ, Alving K, Antczak A, Baraldi E, et al. Exhaled breath condensate: methodological recommendations and unresolved questions. Eur Respir J 2005;26:523-48.
6. Bloemen K, Van Den Heuvel R, Govarts E, Hooyberghs J, Nelen V, Witters E, et al. A new approach to study exhaled proteins as potential biomarkers for asthma. Clin Exp Allergy 2011;41:346-56.
7. Garbacki N, Di Valentin E, Huynh-Thu VA, Geurts P, Irrthum A, Crahay C, et al. MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets. PLoS One 2011;6:e16509.
8. Izzotti A, Larghero P, Longobardi M, Cartiglia C, Camoirano A, Steele VE, et al. Dose-responsiveness and persistence of microRNA expression alterations induced by cigarette smoke in mouse lung. Mutat Res 2011; 717:9-16.
9. Keller S, Sanderson MP, Stoeck A, Altevogt P. Exosomes: from biogenesis and secretion to biological function. Immunol Lett 2006;107:102-8.