The frontal cortex IGF system is down regulated in the term, intrauterine growth restricted fetal baboon

Growth Hormone and IGF Research

Volumn 23, Issue 5, 2013, Pages 187-192

  Xie, L ^a   Antonow Schlorke, I ^b   Schwab, M ^b   McDonald, T J ^a   Nathanielsz, P W ^a   Li, C ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Baboon fetus; Binding proteins; Brain; IGF; IGF receptors; IGFI; IUGR; MTOR; S6

Indexed keywords

HYDROCORTISONE; MAMMALIAN TARGET OF RAPAMYCIN; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN S6; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BABOON; BRAIN GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DIET RESTRICTION; DOWN REGULATION; FEMALE; FETUS; FRONTAL CORTEX; GLIA CELL; HYDROCORTISONE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INTRAUTERINE GROWTH RETARDATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BABOON FETUS; BINDING PROTEINS; BRAIN; IGF; IGF RECEPTORS; IGFI; IUGR; MTOR; S6;

ANIMALS; DOWN-REGULATION; FEMALE; FETAL GROWTH RETARDATION; FETUS; FRONTAL LOBE; GESTATIONAL AGE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MALE; PAPIO; PREGNANCY; SIGNAL TRANSDUCTION; SOMATOMEDINS; TERM BIRTH;

EID: 84882878544     PISSN: 10966374     EISSN: 15322238     Source Type: Journal    
DOI: 10.1016/j.ghir.2013.07.003     Document Type: Article

References (41)

1. Li C., McDonald T.J., Wu G., Nijland M.J., Nathanielsz P.W. Intrauterine growth restriction alters term fetal baboon hypothalamic appetitive peptide balance. J. Endocrinol. 2013, 217.
2. Kramer M.S., Platt R.W., Wen S.W., et al. A new and improved population-based Canadian reference for birth weight for gestational age. Pediatrics 2001, 108:E35.
3. Antonow-Schlorke I., Schwab M., Cox L.A., et al. Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:3011-3016.
4. Han V.K.M., Hill D.J. Growth factors in fetal growth. Textbook of Fetal Physiology 1994, 48-69. Oxford University Press. G.D. Thorburn, R. Harding (Eds.).
5. Li C., Schlabritz-Loutsevitch N.E., Hubbard G.B., et al. Effects of maternal global nutrient restriction on fetal baboon hepatic IGF system genes and gene products. Endocrinology 2009, 150(10):4634-4642.
6. Popken G.J., Dechert-Zeger M., Ye P., D'Ercole A.J. Brain development. Adv. Exp. Med. Biol. 2005, 567:187-220.
7. Niblock M.M., Brunso-Bechtold J.K., Riddle D.R. Insulin-like growth factor I stimulates dendritic growth in primary somatosensory cortex. J. Neurosci. 2000, 20:4165-4176.
8. Fernandez-Cancio M., Esteban C., Carrascosa A., Toran N., Andaluz P., Audi L. IGF-I and not IGF-II expression is regulated by glucocorticoids in human fetal epiphyseal chondrocytes. Growth Horm. IGF Res. 2008, 18:497-505.
9. Fowden A.L., Giussani D.A., Forhead A.J. Intrauterine programming of physiological systems: causes and consequences. Physiology (Bethesda) 2006, 21:29-37.
10. Lee E.K., Gorospe M. Minireview: posttranscriptional regulation of the insulin and insulin-like growth factor systems. Endocrinology 2010, 151:1403-1408.
11. Peng T., Golub T.R., Sabatini D.M. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol. Cell. Biol. 2002, 22:5575-5584.
12. McDonald T., Nijland M., Nathanielsz P. The insulin-like growth factor system and the fetal brain: effects of poor maternal nutrition. Rev. Endocr. Metab. Disord. 2007, 8:71-84.
13. Tsai V., Parker W.E., Orlova K.A., et al. Fetal brain mTOR signaling activation in tuberous sclerosis complex. Cereb. Cortex 2012.
14. Schlabritz-Loutsevitch N.E., Howell K., Rice K., et al. Development of a system for individual feeding of baboons maintained in an outdoor group social environment. J. Med. Primatol. 2004, 33:117-126.
15. Schlabritz-Loutsevitch N.E., Hubbard G.B., Dammann M.J., et al. Normal concentrations of essential and toxic elements in pregnant baboon and fetuses (Papio species). J. Med. Primatol. 2004, 33:152-162.
16. Li C., Schlabritz-Loutsevitch N.E., Hubbard G.B., et al. Effects of maternal global nutrient restriction on fetal baboon hepatic insulin-like growth factor system genes and gene products. Endocrinology 2009, 150:4634-4642.
17. Schlabritz-Loutsevitch N.E., Lopez-Alvarenga J.C., Comuzzie A.G., et al. The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species. Reprod. Sci. 2009, 16:308-319.
18. Rother K.I., Accili D. Role of insulin receptors and IGF receptors in growth and development. Pediatr. Nephrol. 2000, 14:558-561.
19. Dudek H., Datta S.R., Franke T.F., et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997, 275:661-665.
20. Chrysis D., Calikoglu A.S., Ye P., D'Ercole A.J. Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. J. Neurosci. 2001, 21:1481-1489.
21. D'Mello S.R., Galli C., Ciotti T., Calissano P. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:10989-10993.
22. Feldman E.L., Sullivan K.A., Kim B., Russell J.W. Insulin-like growth factors regulate neuronal differentiation and survival. Neurobiol. Dis. 1997, 4:201-214.
23. Cheng C.M., Reinhardt R.R., Lee W.H., Joncas G., Patel S.C., Bondy C.A. Insulin-like growth factor 1 regulates developing brain glucose metabolism. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:10236-10241.
24. Lopez-Lopez C., LeRoith D., Torres-Aleman I. Insulin-like growth factor I is required for vessel remodeling in the adult brain. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:9833-9838.
25. Hellström A., Carlsson B., Niklasson A., et al. IGF-I is critical for normal vascularization of the human retina. J. Clin. Endocrinol. Metab. 2002, 87:3413-3416.
26. Kim J.D., Näntö-Salonen K., Szczepankiewicz J.R., Rosenfeld R.G., Glasscock G.F. Evidence for pituitary regulation of somatic growth, insulin-like growth factors-I and -II, and their binding proteins in the fetal rat. Pediatr. Res. 1993, 33:144-151.
27. Gluckman P.D., Gunn A.J., Wray A., et al. Congenital idiopathic growth hormone deficiency associated with prenatal and early postnatal growth failure. The International Board of the Kabi Pharmacia International Growth Study. J. Pediatr. 1992, 121:920-923.
28. Woods K.A., Camacho-Hübner C., Savage M.O., Clark A.J. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N. Engl. J. Med. 1996, 335:1363-1367.
29. Fernandez C., Tatard V.M., Bertrand N., Dahmane N. Differential modulation of Sonic-hedgehog-induced cerebellar granule cell precursor proliferation by the IGF signaling network. Dev. Neurosci. 2010, 32:59-70.
30. Ko J.M., Park H.K., Yang S., Hwang I.T. Influence of catch-up growth on IGFBP-2 levels and association between IGFBP-2 and cardiovascular risk factors in Korean children born SGA. Endocr. J. 2012, 59:725-733.
31. Nijland M.J., Mitsuya K., Li C., et al. Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability. J. Physiol. 2010, 588:1349-1359.
32. Sonenberg N., Hinnebusch A.G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 2009, 136:731-745.
33. Jacinto E., Hall M.N. TOR signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol. 2003, 4:117-126.
34. Ito T., Funamoto K., Sato N., et al. Maternal undernutrition induces the expression of hypoxia-related genes in the fetal brain. J. Exp. Med. 2012, 226:37-44.
35. Yung H.W., Calabrese S., Hynx D., et al. Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction. Am. J. Pathol. 2008, 173:451-462.
36. Rosario F.J., Jansson N., Kanai Y., Prasad P.D., Powell T.L., Jansson T. Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters. Endocrinology 2011, 152:1119-1129.
37. Gatford K.L., Owens J.A., Li S., et al. Repeated betamethasone treatment of pregnant sheep programs persistent reductions in circulating IGF-I and IGF-binding proteins in progeny. Am. J. Physiol. Endocrinol. Metab. 2008, 295:E170-E178.
38. Ye P., Umayahara Y., Ritter D., et al. Regulation of insulin-like growth factor I (IGF-I) gene expression in brain of transgenic mice expressing an IGF-I-luciferase fusion gene. Endocrinology 1997, 138:5466-5475.
39. Chesik D., De Keyser J. Progesterone and dexamethasone differentially regulate the IGF-system in glial cells. Neurosci. Lett. 2010, 468:178-182.
40. Li C., Ramahi E., Nijland M.J., et al. Up-regulation of the fetal baboon hypothalamus-pituitary-adrenal axis in intrauterine growth restriction: coincidence with hypothalamic glucocorticoid receptor insensitivity and leptin receptor down-regulation. Endocrinology 2013, 154(7):2364-2373.
41. Rodriguez J.S., Bartlett T.Q., Keenan K.E., Nathanielsz P.W., Nijland M.J. Sex-dependent cognitive performance in baboon offspring following maternal caloric restriction in pregnancy and lactation. Reprod. Sci. 2012, 19:493-504.