Synergistic effect of combination topotecan and chronomodulated radiation therapy on xenografted human nasopharyngeal carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 87, Issue 2, 2013, Pages 356-362

  Zhang, Yanling ^a   Chen, Xin ^a   Ren, Peirong ^a   Su, Zhou ^a   Cao, Hongying ^a   Zhou, Jie ^a   Zou, Xiaoyan ^a   Fu, Shaozhi ^a   Lin, Sheng ^a   Fan, Juan ^a   Yang, Bo ^a   Sun, Xiaoyang ^a   Zhou, Yan ^a   Chen, Yue ^a   Yang, Linglin ^a   Wu, Jingbo ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL RHYTHM; IMMUNOHISTOCHEMISTRY; METHODS AND MATERIALS; NASOPHARYNGEAL CARCINOMA; POSSIBLE MECHANISMS; RADIO-SENSITIZATION; SYNERGISTIC EFFECT; THERAPEUTIC EFFECTS;

CELL DEATH; MAMMALS; PHOSPHORYLATION; RADIOTHERAPY; SYNCHRONIZATION;

TUMORS;

DNA TOPOISOMERASE; HISTONE H2AX; PIMONIDAZOLE; TOPOTECAN;

ADJUVANT CHEMORADIOTHERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIZATION; TUMOR XENOGRAFT;

ANIMALS; CELL HYPOXIA; CHRONOTHERAPY; COMBINED MODALITY THERAPY; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, RADIATION; HISTONES; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NASOPHARYNGEAL NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; NITROIMIDAZOLES; PHOSPHORYLATION; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; TIME FACTORS; TOPOISOMERASE I INHIBITORS; TOPOTECAN; TRANSPLANTATION, HETEROLOGOUS;

EID: 84882870934     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2013.05.047     Document Type: Article

References (17)

1. K.C. Chan, J.M. Yee Ko, and K.L. Lung Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma Int J Cancer 129 2011 1826 1837
2. W.C. Cho Nasopharyngeal carcinoma: Molecular biomarker discovery and progress Mol Cancer 6 2007 1 9
3. C. Smith, J. Tsang, and L. Beagley Effective treatment of metastatic forms of Epstein-Barr virus-associated nasopharyngeal carcinoma with a novel adenovirus-based adoptive immunotherapy Cancer Res 72 2012 1116 1125
4. D.M. Brizel, G.S. Sibley, and L.R. Prosnitz Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck Int J Radiat Oncol Biol Phys 38 1997 285 289
5. S. Sahar, and P.S. Corsi Metabolism and cancer: The circadian clock connection Nat Rev Cancer 9 2009 886 896
6. J.S. Takahashi, H.K. Hong, and C.H. Ko The genetics of mammalian circadian order and disorder: Implications for physiology and disease Nat Rev Genet 9 2008 764 775
7. M.W. Greene Circadian rhythms and tumor growth Cancer Lett 318 2012 115 123
8. D. Chapman, A.P. Reuvers, and J. Borsa Chemical radioprotection and radiosensitization of mammalian cells growing in vitro Radiat Res 178 2012 214 222
9. B. Coudert, C. Focan, and E. Donato di Paola It's time for chronotherapy! Eur J Cancer 38 2002 S50 S53
10. G.A. Bjarnason, R.G. Mackenzie, and A. Nabid Comparison of toxicity associated with early morning versus late afternoon radiotherapy in patients with head-and-neck cancer: A prospective randomized trial of the national cancer institute of Canada Clinical Trials Group (HN3) Int J Radiat Oncol Biol Phys 73 2009 166 172
11. C. Savvidis, and M. Koutsilieris Circadian rhythm disruption in cancer biology Mol Med 18 2012 1249 1260
12. M.W. Wu, Z.L. Zeng, and S. Li Circadian variation of plasma cortisol and whole blood reduced glutathione levels in nasopharyngeal carcinoma patients Chin J Cancer 27 2008 237 242
13. L.J. Xian, S. Jian, and Q.Y. Cao Circadian rhythms of DNA synthesis in nasopharyngeal carcinoma cells Chronobiol Int 19 2002 69 76
14. K.A. Mason, R. Komaki, and J.D. Cox Biology-based combined-modality radiotherapy: Workshop report Int J Radiat Oncol Biol Phys 50 2001 1079 1089
15. R.D. Blumenthal, L. Osorio, and R. Ochakovskaya Regulation of tumor drug delivery by blood flow chronobiology Eur J Cancer 36 2000 1876 1884
16. H.C. Xia, F. Wang, and Y.H. Li The circadian gene expression of Per1 and Per2 and their influence on radiotherapeutic sensitivity of glioma in vitro Future Neurol 7 2012 341 348
17. P.F. Innominato, F.A. Levi, and G.A. Bjarnason Chronotherapy and the molecular clock: Clinical implications in oncology Adv Drug Delivery Rev 62 2010 979 1001