Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 34, 2013, Pages

  Tall, Gregory G ^a   Patel, Bharti R ^a   Chan, Puiyee ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN; RIC 8 PROTEIN; UNCLASSIFIED DRUG;

CAENORHABDITIS ELEGANS; DICTYOSTELIUM; DROSOPHILA; EMBRYONIC STEM CELL; LETTER; NEUROSPORA; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; SPODOPTERA FRUGIPERDA; STEADY STATE; WHOLE CELL;

CHEMOTAXIS; DICTYOSTELIUM; GUANINE NUCLEOTIDE EXCHANGE FACTORS; PROTOZOAN PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84882796709     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307476110     Document Type: Letter

References (3)

1. Kataria R, et al. (2013) Dictyostelium Ric8 is a nonreceptor guanine exchange factor for heterotrimeric G proteins and is important for development and chemotaxis. Proc Natl Acad Sci USA 110(16):6424-6429.
2. Gabay M, et al. (2011) Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association. Sci Signal 4(200):ra79.
3. Chan P, Thomas CJ, Sprang SR, Tall GG (2013) Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein α subunits. Proc Natl Acad Sci USA 110(10):3794-3799.