-
1
-
-
0033965997
-
Placental leptin
-
Ashworth C.J., Hoggard N., Thomas L., Mercer J.G., Wallace J.M., Lea R.G. Placental leptin. Reproduction 2000, 5:18.
-
(2000)
Reproduction
, vol.5
, pp. 18
-
-
Ashworth, C.J.1
Hoggard, N.2
Thomas, L.3
Mercer, J.G.4
Wallace, J.M.5
Lea, R.G.6
-
2
-
-
79551527735
-
Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy
-
Bouchard L., Thibault S., Guay S.P., Santure M., Monpetit A., St-Pierre J., Perron P., Brisson D. Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy. Diabetes Care 2010, 33:2436-2441.
-
(2010)
Diabetes Care
, vol.33
, pp. 2436-2441
-
-
Bouchard, L.1
Thibault, S.2
Guay, S.P.3
Santure, M.4
Monpetit, A.5
St-Pierre, J.6
Perron, P.7
Brisson, D.8
-
3
-
-
0035289610
-
Leptin in reproduction
-
Caprio M., Fabbrini E., Isidori A.M., Aversa A., Fabbri A. Leptin in reproduction. TRENDS in Endocrinology and Metabolism 2001, 12:65-72.
-
(2001)
TRENDS in Endocrinology and Metabolism
, vol.12
, pp. 65-72
-
-
Caprio, M.1
Fabbrini, E.2
Isidori, A.M.3
Aversa, A.4
Fabbri, A.5
-
4
-
-
33645650384
-
Elevated amniotic fluid leptin levels in pregnant women who are destined to develop preeclampsia
-
Chan T.F., Su J.H., Chung Y.F., Hsu Y.H., Yeh Y.T., Yuan S.S.F. Elevated amniotic fluid leptin levels in pregnant women who are destined to develop preeclampsia. Acta Obstetricia et Gynecologica Scandinavica 2006, 85:171-174.
-
(2006)
Acta Obstetricia et Gynecologica Scandinavica
, vol.85
, pp. 171-174
-
-
Chan, T.F.1
Su, J.H.2
Chung, Y.F.3
Hsu, Y.H.4
Yeh, Y.T.5
Yuan, S.S.F.6
-
6
-
-
84857189974
-
Understanding transgenerational epigenetic inheritance via the gametes in mammals
-
Daxinger L., Whitelaw E. Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nature Reviews Genetics 2012, 13:153-162.
-
(2012)
Nature Reviews Genetics
, vol.13
, pp. 153-162
-
-
Daxinger, L.1
Whitelaw, E.2
-
7
-
-
2642543386
-
A new growth chart for preterm babies: Babson and Benda's chart updated with recent data and a new format
-
Fenton T. A new growth chart for preterm babies: Babson and Benda's chart updated with recent data and a new format. BMC Pediatrics 2003, 3:13.
-
(2003)
BMC Pediatrics
, vol.3
, pp. 13
-
-
Fenton, T.1
-
8
-
-
84876991711
-
A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants
-
Fenton T.R., Kim J.H. A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants. BMC Pediatrics 2013, 13:59.
-
(2013)
BMC Pediatrics
, vol.13
, pp. 59
-
-
Fenton, T.R.1
Kim, J.H.2
-
9
-
-
79957554838
-
Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta
-
Filiberto A.C., Maccani M.A., Koestler D., Wilhelm-Benartzi C., Avissar-Whiting M., Banister C.E., Gagne L.A., Marsit C.J. Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta. Epigenetics 2011, 6:566-572.
-
(2011)
Epigenetics
, vol.6
, pp. 566-572
-
-
Filiberto, A.C.1
Maccani, M.A.2
Koestler, D.3
Wilhelm-Benartzi, C.4
Avissar-Whiting, M.5
Banister, C.E.6
Gagne, L.A.7
Marsit, C.J.8
-
10
-
-
84856487711
-
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010
-
Flegal K.M., Carroll M.D., Kit B.K., Ogden C.L. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012, 307:491-497.
-
(2012)
JAMA
, vol.307
, pp. 491-497
-
-
Flegal, K.M.1
Carroll, M.D.2
Kit, B.K.3
Ogden, C.L.4
-
11
-
-
53749086325
-
Pre-pregnancy body mass index, gestational weight gain, and other maternal characteristics in relation to infant birth weight
-
Frederick I.O., Williams M.A., Sales A.E., Martin D.P., Killien M. Pre-pregnancy body mass index, gestational weight gain, and other maternal characteristics in relation to infant birth weight. Maternal and Child Health Journal 2008, 12:557-567.
-
(2008)
Maternal and Child Health Journal
, vol.12
, pp. 557-567
-
-
Frederick, I.O.1
Williams, M.A.2
Sales, A.E.3
Martin, D.P.4
Killien, M.5
-
12
-
-
79955701330
-
Leptin and the regulation of body weigh
-
Friedman J.M. Leptin and the regulation of body weigh. The Keio Journal of Medicine 2011, 60:1-9.
-
(2011)
The Keio Journal of Medicine
, vol.60
, pp. 1-9
-
-
Friedman, J.M.1
-
13
-
-
84856016663
-
Elsevier Trophoblast Research Award lecture: Molecular mechanisms underlying estrogen functions in trophoblastic cells - focus on leptin expression
-
Gambino Y.P., Maymo J.L., Perez Perez A., Calvo J.C., Sanchez-Margalet V., Varone C.L. Elsevier Trophoblast Research Award lecture: Molecular mechanisms underlying estrogen functions in trophoblastic cells - focus on leptin expression. Placenta 2012, 33(Suppl.):S63-S70.
-
(2012)
Placenta
, vol.33
, Issue.SUPPL.
-
-
Gambino, Y.P.1
Maymo, J.L.2
Perez Perez, A.3
Calvo, J.C.4
Sanchez-Margalet, V.5
Varone, C.L.6
-
16
-
-
0031834764
-
Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy
-
Highman T.J., Friedman J.E., Huston L.P., Wong W.W., Catalano P.M. Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy. American Journal of Obstetrics and Gynecology 1998, 178:1010-1015.
-
(1998)
American Journal of Obstetrics and Gynecology
, vol.178
, pp. 1010-1015
-
-
Highman, T.J.1
Friedman, J.E.2
Huston, L.P.3
Wong, W.W.4
Catalano, P.M.5
-
17
-
-
84869507003
-
Prenatal and perinatal environmental influences on the human fetal and placental epigenome
-
Hogg K., Price E.M., Hanna C.W., Robinson W.P. Prenatal and perinatal environmental influences on the human fetal and placental epigenome. Clinical Pharmacology and Therapeutics 2012, 92:716-726.
-
(2012)
Clinical Pharmacology and Therapeutics
, vol.92
, pp. 716-726
-
-
Hogg, K.1
Price, E.M.2
Hanna, C.W.3
Robinson, W.P.4
-
19
-
-
41349108655
-
Impact of maternal body mass index on neonate birthweight and body composition
-
Hull H.R., Dinger M.K., Knehans A.W., Thompson D.M., Fields D.A. Impact of maternal body mass index on neonate birthweight and body composition. American Journal of Obstetrics and Gynecology 2008, 198:416e1-416e6.
-
(2008)
American Journal of Obstetrics and Gynecology
, vol.198
-
-
Hull, H.R.1
Dinger, M.K.2
Knehans, A.W.3
Thompson, D.M.4
Fields, D.A.5
-
20
-
-
84879093004
-
Pregnancy outcomes with weight gain above or below the 2009 Institute of Medicine Guidelines
-
Johnson J., Clifton R.G., Roberts J.M., Myatt L., Hauth J.C., Spong C.Y., Varner M.W., Wapner R.J., Thorp J.M., Mercer B.M. Pregnancy outcomes with weight gain above or below the 2009 Institute of Medicine Guidelines. Obstetrics and Gynecology 2013, 121:969-975.
-
(2013)
Obstetrics and Gynecology
, vol.121
, pp. 969-975
-
-
Johnson, J.1
Clifton, R.G.2
Roberts, J.M.3
Myatt, L.4
Hauth, J.C.5
Spong, C.Y.6
Varner, M.W.7
Wapner, R.J.8
Thorp, J.M.9
Mercer, B.M.10
-
21
-
-
84863986133
-
Functions of DNA methylation: islands, start sites, gene bodies and beyond
-
Jones P.A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nature Reviews Genetics 2012.
-
(2012)
Nature Reviews Genetics
-
-
Jones, P.A.1
-
22
-
-
80052664767
-
Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome
-
Jousse C., Parry L., Lambert-Langlais S., Maurin A.C., Averous J., Bruhat A., Carraro V., Tost J., Letteron P., Chen P. Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. The FASEB Journal 2011, 25:3271-3278.
-
(2011)
The FASEB Journal
, vol.25
, pp. 3271-3278
-
-
Jousse, C.1
Parry, L.2
Lambert-Langlais, S.3
Maurin, A.C.4
Averous, J.5
Bruhat, A.6
Carraro, V.7
Tost, J.8
Letteron, P.9
Chen, P.10
-
23
-
-
79551580902
-
Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta-analysis
-
Karakosta P., Chatzi L., Plana E., Margioris A., Castanas E., Kogevinas M. Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta-analysis. Paediatric and Perinatal Epidemiology 2011, 25:150-163.
-
(2011)
Paediatric and Perinatal Epidemiology
, vol.25
, pp. 150-163
-
-
Karakosta, P.1
Chatzi, L.2
Plana, E.3
Margioris, A.4
Castanas, E.5
Kogevinas, M.6
-
24
-
-
84867668434
-
Maternal adiposity - a determinant of perinatal and offspring outcomes?
-
Lawlor D.A., Relton C., Sattar N., Nelson S.M. Maternal adiposity - a determinant of perinatal and offspring outcomes?. Nature Review Endocrinology 2012, 8:679-688.
-
(2012)
Nature Review Endocrinology
, vol.8
, pp. 679-688
-
-
Lawlor, D.A.1
Relton, C.2
Sattar, N.3
Nelson, S.M.4
-
25
-
-
0034974283
-
Prenatal leptin production: evidence that fetal adipose tissue produces leptin
-
Lepercq J., Challier J.C., Guerre-Millo M., Cauzac M., Vidal H., Hauguel-de Mouzon S. Prenatal leptin production: evidence that fetal adipose tissue produces leptin. Journal of Clinical Endocrinology and Metabolism 2001, 86:2409-2413.
-
(2001)
Journal of Clinical Endocrinology and Metabolism
, vol.86
, pp. 2409-2413
-
-
Lepercq, J.1
Challier, J.C.2
Guerre-Millo, M.3
Cauzac, M.4
Vidal, H.5
Hauguel-de Mouzon, S.6
-
26
-
-
80053452296
-
Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter
-
Marchi M., Lisi S., Curcio M., Barbuti S., Piaggi P., Ceccarini G., Nannipieri M., Anselmino M., Di Salvo C., Vitti P. Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter. Epigenetics 2011, 6:1198-1206.
-
(2011)
Epigenetics
, vol.6
, pp. 1198-1206
-
-
Marchi, M.1
Lisi, S.2
Curcio, M.3
Barbuti, S.4
Piaggi, P.5
Ceccarini, G.6
Nannipieri, M.7
Anselmino, M.8
Di Salvo, C.9
Vitti, P.10
-
27
-
-
84858164821
-
Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome
-
Marsit C.J., Maccani M.A., Padbury J.F., Lester B.M. Placental 11-beta hydroxysteroid dehydrogenase methylation is associated with newborn growth and a measure of neurobehavioral outcome. PloS One 2012, 7:e33794.
-
(2012)
PloS One
, vol.7
-
-
Marsit, C.J.1
Maccani, M.A.2
Padbury, J.F.3
Lester, B.M.4
-
28
-
-
33646061633
-
Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small-for-gestational-age infants
-
Martinez-Cordero C., Amador-Licona N., Guizar-Mendoza J.M., Hernandez-Mendez J., Ruelas-Orozco G. Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small-for-gestational-age infants. Archives of Medical Research 2006, 37:490-494.
-
(2006)
Archives of Medical Research
, vol.37
, pp. 490-494
-
-
Martinez-Cordero, C.1
Amador-Licona, N.2
Guizar-Mendoza, J.M.3
Hernandez-Mendez, J.4
Ruelas-Orozco, G.5
-
29
-
-
0031770679
-
Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor
-
Mason M.M., He Y., Chen H., Quon M.J., Reitman M. Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor. Endocrinology 1998, 139:1013.
-
(1998)
Endocrinology
, vol.139
, pp. 1013
-
-
Mason, M.M.1
He, Y.2
Chen, H.3
Quon, M.J.4
Reitman, M.5
-
30
-
-
0030866843
-
Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans
-
Masuzaki H., Ogawa Y., Sagawa N., Hosoda K., Matsumoto T., Mise H., Nishimura H., Yoshimasa Y., Tanaka I., Mori T. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Medicine 1997, 3:1029-1033.
-
(1997)
Nature Medicine
, vol.3
, pp. 1029-1033
-
-
Masuzaki, H.1
Ogawa, Y.2
Sagawa, N.3
Hosoda, K.4
Matsumoto, T.5
Mise, H.6
Nishimura, H.7
Yoshimasa, Y.8
Tanaka, I.9
Mori, T.10
-
31
-
-
79952004504
-
Review: leptin gene expression in the placenta - regulation of a key hormone in trophoblast proliferation and survival
-
Maymo J.L., Pérez Pérez A., Gambino Y., Calvo J.C., Sánchez-Margalet V., Varone C.L. Review: leptin gene expression in the placenta - regulation of a key hormone in trophoblast proliferation and survival. Placenta 2011, 32:S146-S153.
-
(2011)
Placenta
, vol.32
-
-
Maymo, J.L.1
Pérez Pérez, A.2
Gambino, Y.3
Calvo, J.C.4
Sánchez-Margalet, V.5
Varone, C.L.6
-
33
-
-
0037160056
-
Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter
-
Melzner I., Scott V., Dorsch K., Fischer P., Wabitsch M., Bruderlein S., Hasel C., Moller P. Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. Journal of Biology and Chemistry 2002, 277:45420-45427.
-
(2002)
Journal of Biology and Chemistry
, vol.277
, pp. 45420-45427
-
-
Melzner, I.1
Scott, V.2
Dorsch, K.3
Fischer, P.4
Wabitsch, M.5
Bruderlein, S.6
Hasel, C.7
Moller, P.8
-
34
-
-
84882762952
-
The role of epigenetics in the developmental origins of health and disease
-
Michels K.B., Waterland R.A. The role of epigenetics in the developmental origins of health and disease. Epigenetic Epidemiology 2012, 105-116.
-
(2012)
Epigenetic Epidemiology
, pp. 105-116
-
-
Michels, K.B.1
Waterland, R.A.2
-
35
-
-
79551504493
-
The influence of overweight and obesity on longitudinal trends in maternal serum leptin levels during pregnancy
-
Misra V.K., Trudeau S. The influence of overweight and obesity on longitudinal trends in maternal serum leptin levels during pregnancy. Obesity (Silver Spring) 2011, 19:416-421.
-
(2011)
Obesity (Silver Spring)
, vol.19
, pp. 416-421
-
-
Misra, V.K.1
Trudeau, S.2
-
36
-
-
33746640414
-
Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue
-
Noer A., Sorensen A.L., Boquest A.C., Collas P. Stable CpG hypomethylation of adipogenic promoters in freshly isolated, cultured, and differentiated mesenchymal stem cells from adipose tissue. Molecular Biology of the Cell 2006, 17:3543-3556.
-
(2006)
Molecular Biology of the Cell
, vol.17
, pp. 3543-3556
-
-
Noer, A.1
Sorensen, A.L.2
Boquest, A.C.3
Collas, P.4
-
37
-
-
84869504738
-
The ever growing complexity of placental epigenetics - role in adverse pregnancy outcomes and fetal programming
-
Novakovic B., Saffery R. The ever growing complexity of placental epigenetics - role in adverse pregnancy outcomes and fetal programming. Placenta 2012, 33:959-970.
-
(2012)
Placenta
, vol.33
, pp. 959-970
-
-
Novakovic, B.1
Saffery, R.2
-
38
-
-
66149172037
-
Maternal and child obesity: the causal link
-
Oken E. Maternal and child obesity: the causal link. Obstetrics and Gynecology Clinics 2009, 36.
-
(2009)
Obstetrics and Gynecology Clinics
, vol.36
-
-
Oken, E.1
-
39
-
-
79951654676
-
Obesity in pregnancy: implications for the mother and lifelong health of the child. A consensus statement
-
Poston L., Harthoorn L.F., Van Der Beek E.M. Obesity in pregnancy: implications for the mother and lifelong health of the child. A consensus statement. Pediatric Research 2011, 69:175-180.
-
(2011)
Pediatric Research
, vol.69
, pp. 175-180
-
-
Poston, L.1
Harthoorn, L.F.2
Van Der Beek, E.M.3
-
40
-
-
78049348070
-
Recommendations for weight gain during pregnancy in the context of the obesity epidemic
-
Rasmussen K.M., Abrams B., Bodnar L.M., Butte N.F., Catalano P.M., Siega-Riz A.M. Recommendations for weight gain during pregnancy in the context of the obesity epidemic. Obstetrics and Gynecology 2010, 116:1191-1195.
-
(2010)
Obstetrics and Gynecology
, vol.116
, pp. 1191-1195
-
-
Rasmussen, K.M.1
Abrams, B.2
Bodnar, L.M.3
Butte, N.F.4
Catalano, P.M.5
Siega-Riz, A.M.6
-
42
-
-
78649647280
-
A meta-analysis of relationship between birth weight and cord blood leptin levels in newborns
-
Ren R.X., Shen Y. A meta-analysis of relationship between birth weight and cord blood leptin levels in newborns. World Journal of Pediatrics 2010, 6:311-316.
-
(2010)
World Journal of Pediatrics
, vol.6
, pp. 311-316
-
-
Ren, R.X.1
Shen, Y.2
-
43
-
-
84857287862
-
Fetal programming and metabolic syndrome
-
Rinaudo P., Wang E. Fetal programming and metabolic syndrome. Annual Review in Physiology 2012, 74:107-130.
-
(2012)
Annual Review in Physiology
, vol.74
, pp. 107-130
-
-
Rinaudo, P.1
Wang, E.2
-
44
-
-
33746911576
-
The Dutch famine and its long-term consequences for adult health
-
Roseboom T., de Rooij S., Painter R. The Dutch famine and its long-term consequences for adult health. Early Human Development 2006, 82:485-491.
-
(2006)
Early Human Development
, vol.82
, pp. 485-491
-
-
Roseboom, T.1
de Rooij, S.2
Painter, R.3
-
45
-
-
34249679093
-
Small for gestational age: short stature and beyond
-
Saenger P., Czernichow P., Hughes I., Reiter E.O. Small for gestational age: short stature and beyond. Endocrinology Review 2007, 28:219-251.
-
(2007)
Endocrinology Review
, vol.28
, pp. 219-251
-
-
Saenger, P.1
Czernichow, P.2
Hughes, I.3
Reiter, E.O.4
-
46
-
-
76049126281
-
Allelic skewing of DNA methylation is widespread across the genome
-
Schalkwyk L.C., Meaburn E.L., Smith R., Dempster E.L., Jeffries A.R., Davies M.N., Plomin R., Mill J. Allelic skewing of DNA methylation is widespread across the genome. American Journal of Human Genetics 2010, 86:196-212.
-
(2010)
American Journal of Human Genetics
, vol.86
, pp. 196-212
-
-
Schalkwyk, L.C.1
Meaburn, E.L.2
Smith, R.3
Dempster, E.L.4
Jeffries, A.R.5
Davies, M.N.6
Plomin, R.7
Mill, J.8
-
47
-
-
0031006009
-
Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight
-
Schubring C., Kiess W., Englaro P., Rascher W., Dötsch J., Hanitsch S., Attanasio A., Blum W.F. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. Journal of Clinical Endocrinology and Metabolism 1997, 82:1480-1483.
-
(1997)
Journal of Clinical Endocrinology and Metabolism
, vol.82
, pp. 1480-1483
-
-
Schubring, C.1
Kiess, W.2
Englaro, P.3
Rascher, W.4
Dötsch, J.5
Hanitsch, S.6
Attanasio, A.7
Blum, W.F.8
-
48
-
-
36749093765
-
In vivo methylation patterns of the leptin promoter in human and mouse
-
Stöger R. In vivo methylation patterns of the leptin promoter in human and mouse. Epigenetics 2006, 1:155-162.
-
(2006)
Epigenetics
, vol.1
, pp. 155-162
-
-
Stöger, R.1
-
49
-
-
80052236883
-
The global obesity pandemic: shaped by global drivers and local environments
-
Swinburn B.A., Sacks G., Hall K.D., McPherson K., Finegood D.T., Moodie M.L., Gortmaker S.L. The global obesity pandemic: shaped by global drivers and local environments. The Lancet 2011, 378:804-814.
-
(2011)
The Lancet
, vol.378
, pp. 804-814
-
-
Swinburn, B.A.1
Sacks, G.2
Hall, K.D.3
McPherson, K.4
Finegood, D.T.5
Moodie, M.L.6
Gortmaker, S.L.7
-
50
-
-
70349999407
-
DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
-
Tobi E.W., Lumey L.H., Talens R.P., Kremer D., Putter H., Stein A.D., Slagboom P.E., Heijmans B.T. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Human Molecular Genetics 2009, 18:4046-4053.
-
(2009)
Human Molecular Genetics
, vol.18
, pp. 4046-4053
-
-
Tobi, E.W.1
Lumey, L.H.2
Talens, R.P.3
Kremer, D.4
Putter, H.5
Stein, A.D.6
Slagboom, P.E.7
Heijmans, B.T.8
-
52
-
-
0036160648
-
DNA demethylation modulates mouse leptin promoter activity during the differentiation of 3T3-L1 cells
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Yokomori N., Tawata M., Onaya T. DNA demethylation modulates mouse leptin promoter activity during the differentiation of 3T3-L1 cells. Diabetologia 2002, 45:140-148.
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(2002)
Diabetologia
, vol.45
, pp. 140-148
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Yokomori, N.1
Tawata, M.2
Onaya, T.3
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