Measurement of tear film thickness using ultrahigh- resolution optical coherence tomography

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 8, 2013, Pages 5578-5583

  Werkmeister, René M ^a   Alex, Aneesh ^a   Kaya, Semira ^b   Unterhuber, Angelika ^a   Hofer, Bernd ^a   Riedl, Jasmin ^a   Bronhagl, Michael ^a   Vietauer, Martin ^a   Schmidl, Doreen ^b   Schmoll, Tilman ^a   Garhöfer, Gerhard ^b   Drexler, Wolfgang ^a   Leitgeb, Rainer A ^a   Groeschl, Martin ^c   Schmetterer, Leopold ^a,b  

^a Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Dry eyes; Optical coherence tomography; Tear film thickness

Indexed keywords

ADULT; ARTICLE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SIGNAL NOISE RATIO; SLIT LAMP; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TEAR FILM THICKNESS; VISUAL SYSTEM PARAMETERS;

DRY EYES; OPTICAL COHERENCE TOMOGRAPHY; TEAR FILM THICKNESS;

ADULT; BLINKING; CORNEA; DRY EYE SYNDROMES; FEMALE; HUMANS; IMAGE ENHANCEMENT; MALE; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; TEARS; TOMOGRAPHY, OPTICAL COHERENCE; YOUNG ADULT;

EID: 84882756728     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-11920     Document Type: Article

References (34)

1. Epidemiology Subcommittee of the International Dry Eye WorkShop. The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop. Ocul Surf. 2007;5:93-107.
2. Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop. Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye WorkShop. Ocul Surf. 2007;5:108-152.
3. Ehlers N. The thickness of the precorneal film. Acta Ophthalmol. 1965;43:92-100.
4. Mishima S. Some physiological aspects of the precorneal tear film. Arch Ophthalmol. 1965;73:233-241.
5. Benedetto DA, Shah DO, Kaufman HE. The instilled fluid dynamics and surface chemistry of polymers in the preocular tear film. Invest Ophthalmol. 1975;14:887-902.
6. Fogt N, King-Smith PE, Tuell G. Interferometric measurement of tear film thickness by use of spectral oscillations. J Opt Soc Am A Opt Image Sci Vis. 1998;15:268-275.
7. Prydal JI, Artal P, Woon H, Campbell FW. Study of human precorneal tear film thickness and structure using laser interferometry. Invest Ophthalmol Vis Sci. 1992;33:2006-2011.
8. Muscat S, McKay N, Parks S, Kemp E, Keating D. Repeatability and reproducibility of corneal thickness measurements by optical coherence tomography. Invest Ophthalmol Vis Sci. 2002;43:1791-1795.
9. Schmoll T, Unterhuber A, Kolbitsch C, Le T, Stingl A, Leitgeb R. Precise thickness measurements of Bowman's layer, epithelium, and tear film. Optom Vis Sci. 2012;89:E795-E802.
10. Christopoulos V, Kagemann L, Wollstein G, et al. In vivo corneal high-speed, ultra high-resolution optical coherence tomography. Arch Ophthalmol. 2007;125:1027-1035.
11. Leitgeb R, Drexler W, Unterhuber A, et al. Ultrahigh resolution Fourier domain optical coherence tomography. Opt Express. 2004;12:2156-2165.
12. Torzicky T, Pircher M, Zotter S, Bonesi M, Gotzinger E, Hitzenberger CK. Automated measurement of choroidal thickness in the human eye by polarization sensitive optical coherence tomography. Opt Express. 2012;20:7564-7574.
13. Nassif N, Cense B, Park B, et al. In vivo high-resolution videorate spectral-domain optical coherence tomography of the human retina and optic nerve. Opt Express. 2004;12:367-376.
14. Alex A, Povazay B, Hofer B, et al. Multispectral in vivo threedimensional optical coherence tomography of human skin. J Biomed Opt. 2010;15:026025.
15. Wang J, Fonn D, Simpson TL, Jones L. Precorneal and pre-and postlens tear film thickness measured indirectly with optical coherence tomography. Invest Ophthalmol Vis Sci. 2003;44: 2524-2528.
16. Wang J, Aquavella J, Palakuru J, Chung S, Feng C. Relationships between central tear film thickness and tear menisci of the upper and lower eyelids. Invest Ophthalmol Vis Sci. 2006;47: 4349-4355.
17. Chen Q, Wang J, Tao A, Shen M, Jiao S, Lu F. Ultrahighresolution measurement by optical coherence tomography of dynamic tear film changes on contact lenses. Invest Ophthalmol Vis Sci. 2010;51:1988-1993.
18. Palakuru JR, Wang J, Aquavella JV. Effect of blinking on tear volume after instillation of midviscosity artificial tears. Am J Ophthalmol. 2008;146:920-924.
19. Yadav R, Lee KS, Rolland JP, Zavislan JM, Aquavella JV, Yoon G. Micrometer axial resolution OCT for corneal imaging. Biomed Opt Express. 2011;2:3037-3046.
20. Kottaiyan R, Yoon G, Wang Q, Yadav R, Zavislan JM, Aquavella JV. Integrated multimodal metrology for objective and noninvasive tear evaluation. Ocul Surf. 2012;10:43-50.
21. Qiu X, Gong L, Lu Y, Jin H, Robitaille M. The diagnostic significance of Fourier-domain optical coherence tomography in Sjögren syndrome, aqueous tear deficiency and lipid tear deficiency patients. Acta Ophthalmol. 2012;90:e359-e366.
22. American National Standards Institute. American National Standard for Safe Use of Lasers. Orlando, FL: The Laser Institute of America; 2000; ANSI Z136.1-2000.
23. Thevenaz P, Ruttimann UE, Unser M. A pyramid approach to subpixel registration based on intensity. IEEE Trans Image Process. 1998;7:27-41.
24. Dijkstra EW. A note on two problems in connexion with graphs. Numerische Mathematik. 1959;1:269-271.
25. Tuchin VV. Optical Clearing of Tissue and Blood. Bellingham, WA: SPIE Publications; 2005.
26. Craig JP, Simmons PA, Patel S, Tomlinson A. Refractive index and osmolality of human tears. Optom Vis Sci. 1995;72:718-724.
27. Lin RC, Shure MA, Rollins AM, Izatt JA, Huang D. Group index of the human cornea at 1.3-microm wavelength obtained in vitro by optical coherence domain reflectometry. Opt Lett. 2004;29:83-85.
28. Bartko JJ, Carpenter WT Jr. On the methods and theory of reliability. J Nerv Ment Dis. 1976;163:307-317.
29. Nichols JJ, Mitchell GL, King-Smith PE. Thinning rate of the precorneal and prelens tear films. Invest Ophthalmol Vis Sci. 2005;46:2353-2361.
30. King-Smith PE, Nichols JJ, Nichols KK, Fink BA, Braun RJ. Contributions of evaporation and other mechanisms to tear film thinning and break-up. Optom Vis Sci. 2008;85:623-630.
31. Graig JP, Tomlinson A, McCann A. Tear Film. In: Besharse J, Dana R, eds. Encyclopedia of the Eye. Oxford, UK: Elsevier B.V.; 2010.
32. Wang J, Cui L, Shen M, Perez VL, Wang MR. Ultra-high resolution optical coherence tomography for monitoring tear meniscus volume in dry eye after topical cyclosporine treatment. Clin Ophthalmol. 2012;6:933-938.
33. Tomlinson A, Bron AJ, Korb DR, et al. The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee. Invest Ophthalmol Vis Sci. 2011;52: 2006-2049.
34. Nichols KK, Foulks GN, Bron AJ, et al. The international workshop on meibomian gland dysfunction: executive summary. Invest Ophthalmol Vis Sci. 2011;52:1922-1929.