PH and temperature effects on the hydrolysis of three β-lactam antibiotics: Ampicillin, cefalotin and cefoxitin

Science of the Total Environment

Volumn 466-467, Issue , 2014, Pages 547-555

  Mitchell, Shannon M ^a   Ullman, Jeffrey L ^b   Teel, Amy L ^a   Watts, Richard J ^a  

^a Washington State University   (United States)

^b J Crayton Pruitt Family Department of Biomedical Engineering   (United States)

Author keywords

lactam; Ampicillin; Antibiotic hydrolysis; Cefalotin; Cefoxitin; Cephalosporin

Indexed keywords

AMPICILLIN; ANTIBIOTIC HYDROLYSIS; CEFALOTIN; CEFOXITIN; CEPHALOSPORIN;

ALKALINITY; DEGRADATION; FUNCTIONAL GROUPS; HYDROLYSIS;

ANTIBIOTICS;

AMPICILLIN; CEFALOTIN; CEFOXITIN; ANTIINFECTIVE AGENT;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; DEGRADATION; HYDROLYSIS; PH; TEMPERATURE EFFECT;

ANTIMICROBIAL ACTIVITY; ARTICLE; CATALYSIS; DRUG DEGRADATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG SOLUBILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENVIRONMENTAL TEMPERATURE; EPIMERIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH TEMPERATURE; LOW TEMPERATURE; MASS SPECTROMETRY; NUCLEOPHILICITY; PH; PRIORITY JOURNAL; TEMPERATURE; CHEMISTRY; HYDROLYSIS; METABOLISM;

AMPICILLIN; ANTI-BACTERIAL AGENTS; CEFOXITIN; CEPHALOTHIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; TEMPERATURE;

EID: 84882755074     PISSN: 00489697     EISSN: 18791026     Source Type: Journal    
DOI: 10.1016/j.scitotenv.2013.06.027     Document Type: Article

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