Nutritional aspect of tryptophan metabolism

International Journal of Tryptophan Research

Volumn 6, Issue SUPPL.1, 2013, Pages 3-8

  Fukuwatari, Tsutomu ^a   Shibata, Katsumi ^a  

^a UNIVERSITY OF SHIGA PREFECTURE   (Japan)

Author keywords

Nicotinamide; Nutrition; Tryptophan

Indexed keywords

EID: 84882657086     PISSN: None     EISSN: 11786469     Source Type: Journal    
DOI: 10.4137/IJTR.S11588     Document Type: Review

References (42)

1. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington (DC): National Academies Press (US); 1998.
2. Seal AJ, Creeke PI, Dibari F, et al. Low and deficient niacin status and pellagra are endemic in postwar Angola. Am J Clin Nutr. 2007;85(1):218-24.
3. Ministry of Health, Labor, and Welfare of Japan. Dietary reference Intakes for Japanese, 2010. Tokyo; 2009.
4. Ministry of Health, Labor, and Welfare of Japan. The National Health and Nutrition Survey, 2010. Tokyo; 2012.
5. DesGroseilliers JP, Shiffman NJ. Pellagra. Can Med Assoc J. 1976;115(8): 768-70.
6. Shibata K, Matsuo H. Effect of dietary tryptophan levels on the urinary excretion of nicotinamide and its metabolites in rats fed a niacin-free diet or a constant total protein level. J Nutr. 1990;120(10):1191-7.
7. Fukuwatari T, Wada H, Shibata K. Age-related alterations of B-group vitamin contents in urine, blood and liver from rats. J Nutr Sci Vitaminol. 2008;54(5):347-52.
8. Shibata K, Sanada H, Yuyama S, Suzuki T. Evaluation of niacin nutrition in persons of advanced age supposed by the urinary excretion of niacin metabolites. Vitamins (Japan). 1994;68:365-72.
9. Wada H, Fukuwatari T, Sasaki R, et al. Blood NAD and NADP levels in the elderly. Vitamins (Japan). 2006;80(3):125-7.
10. Yoshida R, Nukiwa T, Watanabe Y, Fujiwara M, Hirata F, Hayaishi O. Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice. Arch Biochem Biophys. 1980;203(1): 343-51.
11. Truscott RJ, Elderfield AJ. Relationship between serum tryptophan and tryptophan metabolite levels after tryptophan ingestion in normal subjects and age-related cataract patients. Clin Sci (Lond). 1995;89(6):591-9.
12. Comai S, Costa CV, Ragazzi E, Bertazzo A, Allegri G. The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats. Clin Chim Acta. 2005;360(1-2):67-80.
13. Fukuwatari T, Morikawa Y, Sugimoto E, Shibata K. Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats. Biosci Biotechnol Biochem. 2002;66(6):1196-204.
14. Fukuwatari T, Morikawa Y, Hayakawa F, Sugimoto E, Shibata K. Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats. Biosci Biotechnol Biochem. 2001;65(10):2154-61.
15. Saito K, Fujigaki S, Heyes MP, et al. Mechanism of increases in l-kynurenine and quinolinic acid in renal insufficiency. Am J Physiol Renal Physiol. 2000;279(3):F565-72.
16. Okuno A, Fukuwatari T, Shibata K. Urinary excretory ratio of anthranilic acid/kynurenic acid as an index of the tolerable amount of tryptophan. Biosci Biotechnol Biochem. 2008;72(7):1667-72.
17. Shibata K, Mushiage M, Kondo T, Hayakawa T, Tsuge H. Effects of vitamin B6 deficiency on the conversion ratio of tryptophan to niacin. Biosci Biotechnol Biochem. 1995;59(11):2060-3.
18. Fukuwatari T, Ohsaki S, Fukuoka S, Sasaki R, Shibata K. Phthalate esters enhance quinolinate production by inhibiting a-amino-ß-carboxymuconate-e-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway. Toxicol Sci. 2004;81(2):302-8.
19. Shibata K, Murotani M, Onodera M. Difference in tryptophan-nicotinamide conversion according to dietary nitrogen sources; casein, casein hydrolysate, and mixtures of amino acids. Biosci Biotech Biochem. 1992;56:665-9.
20. Tanabe A, Egashira Y, Fukuoka S, Shibata K, Sanada H. Expression of rat hepatic 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase is affected by a high protein diet and by streptozotocin-induced diabetes. J Nutr. 2002;132(6):1153-9.
21. Fukuwatari T, Murakami M, Ohta M, et al. Changes in the urinary excretion of the metabolites of the tryptophan-niacin pathway during pregnancy in Japanese women and rats. J Nutr Sci Vitaminol. 2004;50(6):392-8.
22. Shibata K, Matsuo H. Effect of dietary tryptophan levels on the urinary excretion of nicotinamide and its metabolites in rats fed a niacin-free diet or a constant total protein level. J Nutr. 1990;120(10):1191-7.
23. Egashira Y, Murotani G, Tanabe A, et al. Differential effects of dietary fatty acids on rat liver a-amino-ß-carboxymuconate-e-semialdehyde decarboxylase activity and gene expression. Biochim Biophys Acta. 2004;1686(1-2): 118-24.
24. Shibata K, Toda S. Effect of thyroxine on the metabolism of tryptophan to nicotinamide in rats. Biosci Biotechnol Biochem. 1994;58:1757-62.
25. Shibata K. Effects of adrenalin on the conversion ratio of tryptophan to niacin in rats. Biosci Biotechnol Biochem. 1995;59(11):2127-9.
26. Shin M, Mori Y, Kimura A, et al. NAD+ biosynthesis and metabolic fluxes of tryptophan in hepatocytes isolated from rats fed a clofibrate-containing diet. Biochem Pharmacol. 1996;52(2):247-52.
27. Shibata K, Fukuwatari T, Sugimoto E. Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats. Biosci Biotechnol Biochem. 2001;65(6): 1339-46.
28. Krehl WA, Teply LJ, Sarma PS, Elvehjem CA. Corn as an etiological factor in the production of a nicotinic acid deficiency in the rat. Science. 1945;101(2620):489-90.
29. Henderson LM, Deoder T, Krehl WA, Elevehjem CA. Factors of affecting the growth of rats receiving niacin-tryptophan-deficient diets. J Biol Chem. 1947;170(1):261-8.
30. Zhang JZ, Henning SM, Swendseid ME. Poly(ADP-ribose) polymerase activity and DNA strand breaks are affected in tissues of niacin-deficient rats. J Nutr. 1993;123(8):E1349-55.
31. Jean MR, Jackson TM, Driscoll ER, Kirkland JB. Niacin deficiency lowers tissue poly (ADP-ribose) and NAD concentrations in Fischer-344 rats. J Nutr. 1994;124:1597-603.
32. Terakata M, Fukuwatari T, Sano M, et al. Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice. J Nutr. 2012;142(12):2148-53.
33. Horwitt MK, Harvey CC, Rothwell WS, Cutler JL, Haffron D. Tryptophan-niacin relationships in man: Studies with diets deficient in riboflavin and niacin, together with observations on the excretion of nitrogen and niacin metabolites. J Nutr. 1956;60:1-43.
34. Goldsmith GA, Miller ON, Unglaub WG. Efficiency of tryptophan as a niacin precursor in man. J Nutr. 1961;73:172-6.
35. Nakagawa I, Takahashi T, Suzuki T, Masana Y. Effect in man of the addition of tryptophan or niacin to the diet on the excretion of their metabolites. J Nutr. 1969;99:325-30.
36. Fukuwatari T, Ohta M, Kimura N, Sasaki R, Shibata K. Conversion ratio of tryptophan to niacin in Japanese women fed on a purified diet conforming to the Japanese Dietary Reference Intakes. J Nutr Sci Vitaminol. 2004;50(6):385-91.
37. Moore MC, Purdy MB, Gibbens EJ, Hollinger ME, Goldsmith G. Food habits of women during pregnancy. J Am Diet Ass. 1947;23:847-53.
38. Shibata K, Onodera M. Comparison of tryptophan-niacin conversion in rats fed with a nicotinic acid-free diet containing egg white, egg white proteolysate, or mixtures of amino acids. Agric Biol Chem. 1991;55: 1291-8.
39. Shibata K. Effect of adding the limiting amino acids to an amino acid diet simulating rice protein on the conversion of tryptophan to nicotinamide in rat. Biosci Biotech Biochem. 1994;58(2):442-3.
40. Shibata K, Kondo T, Yonejima M. Conversion ratio of tryptophan to niacin in rats fed a vitamin B1-free diet. J Nutr Sci Vitaminol. 1997;43(4): 479-83.
41. Kimura N, Fukuwatari T, Sasaki R, Shibata K. The necessity of niacin in rats fed on a high protein diet. Biosci Biotechnol Biochem. 2005;69(2): 273-9.
42. Shibata K, Kondo T. Effect of progesterone and estrone on the conversion of tryptophan to nicotinamide in rats. Biosci Biotech Biochem. 1993;57: 1890-3.