Medications in the first trimester of pregnancy: Most common exposures and critical gaps in understanding fetal risk

Pharmacoepidemiology and Drug Safety

Volumn 22, Issue 9, 2013, Pages 1013-1018

  Thorpe, Phoebe G ^a   Gilboa, Suzanne M ^a   Hernandez Diaz, Sonia ^b   Lind, Jennifer ^a   Cragan, Janet D ^a   Briggs, Gerald ^c,d,e   Kweder, Sandra ^f   Friedman, Jan M ^g   Mitchell, Allen A ^h   Honein, Margaret A ^a  

^a NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e WASHINGTON STATE UNIVERSITY   (United States)

^f CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^g UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^h BOSTON UNIVERSITY   (United States)

Author keywords

Fetal risk; Medication; Pharmacoepidemiology; Pregnancy; Teratogen

Indexed keywords

ACETYLSALICYLIC ACID; AMOXICILLIN; BISMUTH SALICYLATE; CETIRIZINE; CHLORPHENIRAMINE; DEXTROMETHORPHAN; DIPHENHYDRAMINE; DOCUSATE SODIUM; DOXYLAMINE; ESTROGEN; FAMOTIDINE; FEXOFENADINE; GESTAGEN; GUAIFENESIN; IBUPROFEN; ISPAGULA; LORATADINE; MICONAZOLE; NAPROXEN; OMEPRAZOLE; OXYMETAZOLINE; PARACETAMOL; PHENYLEPHRINE; PROGESTERONE; PROMETHAZINE; PSEUDOEPHEDRINE; RANITIDINE; SALBUTAMOL; SIMETHICONE; UNINDEXED DRUG;

ARTICLE; BIRTH DEFECT; CLINICAL ASSESSMENT; CONTROLLED STUDY; DELIVERY; DRUG INFORMATION; DRUG SAFETY; DRUG USE; FEMALE; FETUS RISK; FIRST TRIMESTER PREGNANCY; HUMAN; INFANT; MAJOR CLINICAL STUDY; MEDICAL EXPERT; MOTHER; MULTICENTER STUDY; ORAL CONTRACEPTION; PREGNANT WOMAN; PRENATAL DRUG EXPOSURE; PRESCRIPTION; PRIORITY JOURNAL; RATING SCALE; RISK FACTOR; SELF REPORT; TERATOGENICITY; TERIS SCALE;

FETAL RISK; MEDICATION; PHARMACOEPIDEMIOLOGY; PREGNANCY; TERATOGEN;

ADVERSE DRUG REACTION REPORTING SYSTEMS; DRUG PRESCRIPTIONS; DRUG UTILIZATION REVIEW; FEMALE; FETAL DEVELOPMENT; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; MATERNAL EXPOSURE; NONPRESCRIPTION DRUGS; PHARMACOEPIDEMIOLOGY; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PRESCRIPTION DRUGS; QUESTIONNAIRES; RISK; UNITED STATES;

EID: 84882634149     PISSN: 10538569     EISSN: 10991557     Source Type: Journal    
DOI: 10.1002/pds.3495     Document Type: Article

References (14)

1. Mitchell AA, Gilboa SM, Werler MM, et al. Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008. Am J Obstet Gynecol 2011; 205(1): 51.e1-51.e8.
2. Adam MP, Polifka JE, Friedman JM. Evolving knowledge of the teratogenicity of medications in human pregnancy. Am J Med Genet C Semin Med Genet 2011; 157(3): 175-182.
3. Werler MM, Mitchell AA, Hernandez-Diaz S, et al. Use of over-the-counter medications during pregnancy. Am J Obstet Gynecol 2005; 193; 771-777.
4. Mitchell AA, Cottler LB, Shapiro S. Effect of questionnaire design on recall of drug exposure in pregnancy. Am J Epidemiol 1986; 123(4): 670-676.
5. Friedman JM, Polifka JE. TERIS. In Micromedex Reproductive Risk Information System (REPRORISK). Englewood, Colorado: Thomson MICROMEDEX, 2011.
6. FDA product labels accessed for pregnancy categories at Dailymed. http://dailymed.nlm.nih.gov/dailymed/about.cfm. (accessed 15 May 2012).
7. Federal Register. Washington, DC: Office of the Federal Register, National Archives and Records Administration. In; 1979.
8. Lo WY, Friedman JM. Teratogenicity of recently introduced medications in human pregnancy. Obstet Gynecol 2002; 100(3): 465-473.
9. Ahluwalia IB, Mack KA, Mokdad A. Report from the CDC. Changes in selected chronic disease-related risks and health conditions for nonpregnant women 18-44years old BRFSS. J Womens Health (Larchmt) 2005; 14(5): 382-386.
10. Wysowski DK, Governale LA, Swann J. Trends in outpatient prescription drug use and related costs in the US: 1998-2003. Pharmacoeconomics 2006; 24(3): 233-236.
11. American College of Obstretricians and Gynecologists Committee on Obstetric Practices. ACOG Committee Opinion No. 494: Sulfonamides, nitrofurantoin, and risk of birth defects. Obstet Gynecol 2011; 117(6): 1484-1485.
12. Briggs GB, Freeman RK, Sumner JY (Eds.). (2011). Drugs in Pregnancy and Lactation (9th edn), Philadelphia, PA: Lippincott Williams & Wilkins.
13. Kweder SL. Drugs and biologics in pregnancy and breastfeeding: FDA in the 21st century. Birth Defects Res A Clin Mol Teratol 2008; 82(9): 605-609.
14. Petersen EE, Rasmussen SA, Daniel KL, Yazdy MM, Honein MA. Prescription medication borrowing and sharing among women of reproductive age. J Womens Health (Larchmt) 2008; 17(7): 1073-1080.