Lack of association between allelic status and myostatin content in lambs with the myostatin g+6723G > A allele

Journal of Animal Science

Volumn 91, Issue 1, 2013, Pages 78-89

  Haynes, F E M ^a,e   Greenwood, P L ^a,b   McDonagh, M B ^a,c   McMahon, C D ^d   Nicholas, G D ^d   Berry, C J ^d   Oddy, V H ^e  

^a Sheep CRC   (Australia)

^b UNIVERSITY OF NEW ENGLAND   (Australia)

^c NSW DEPARTMENT OF PRIMARY INDUSTRIES   (Australia)

^d DEPARTMENT OF PRIMARY INDUSTRIES   (Australia)

^e RUAKURA RESEARCH CENTRE   (New Zealand)

Author keywords

Carcass; Computed tomography; Lamb; Myofibers; Myostatin; Myostatin protein

Indexed keywords

MYOSTATIN;

AGING; ALLELE; ANIMAL; ARTICLE; EATING; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; MALE; METABOLISM; POINT MUTATION; SHEEP; SKELETAL MUSCLE; WEIGHT GAIN;

AGING; ALLELES; ANIMALS; EATING; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; MALE; MUSCLE, SKELETAL; MYOSTATIN; POINT MUTATION; SHEEP; WEIGHT GAIN;

EID: 84882625125     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2012-5482     Document Type: Article

References (37)

1. Aus-Meat. 1998. Handbook of Australian meat. Aus-Meat, Brisbane, QLD, Australia.
2. Arthur, P. F. 1995. Double muscling in cattle: A review. Aust. J. Agr. Res. 46:1493-1515.
3. Bignell, C., A. Malau-Aduli, P. Nicholas, R. McCulloch, and J. W. Kijas. 2010. East Friesian sheep carry a Myostatin allele known to cause muscle hypertrophy in other breeds. Anim. Genet. 41:445-446.
4. Boman, A., G. Klemetsdal, T. Blichfeldt, O. Nafstad, and D. I. Våge. 2009. A frameshift mutation in the coding region of myostatin gene (MSTN) affects carcass conformation and fatness in Norwegian White Sheep (Ovis aries). Anim. Genet. 40. 418-422.
5. Bullough, W. S. 1962. The control of mitotic activity in adult mammalian tissues. Biol. Rev. 37:307-342.
6. Bullough, W. S. 1965. Mitotic and functional homeostasis: Aspeculative review. Cancer Res. 25:1683-1727.
7. Bünger, L., E. A. Navajas, L. Stevenson, N. R. Lambe, C. A. Maltin, G. Simm, A. V. Fisher, and K. C. Chang. 2009. Muscle fibre characteristics of two contrasting sheep breeds: Scottish Blackface and Texel. Meat Sci. 81:372-381.
8. Clop, A., F. Marcq, H. Takeda, D. Pirottin, X. Tordoir, B. Bibe, J. Bouix, F. Caiment, J. M. Elsen, F. Eychenne, C. Larzul, E. Laville, F. Meish, D. Milenkovic, J. Tobin, C. Charlier, and M. Georges. 2006. A mutation creating a potential illegitimate microRNA target site in the myostatin gene effects muscularity in sheep. Nat. Genet. 38:813-818.
9. Gonzalez-Cadavid, N. F., W. E. Taylor, K. Yarasheski, I. Sinha-Hikim, K. Ma, S. Ezzat, R. Shen, R. Lalani, S. Asa, M. Mamita, G. Nair, S. Arver, and S. Bhasin. 1998. Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. P. Natl. Acad. Sci. USA. 95:14938-14943.
10. Greenwood, P. L. 2008. Phenotyping sheep genetic variants. NSW Department of Primary Industries. Meat and Livestock Limited, Armidale, NSW, Australia.
11. Greenwood, P. L., J. J. Davis, G. M. Gaunt, and G. R. Ferrier. 2006a. Influences on the loin and cellular characteristics of the m. longissimus lumborum of Australian Poll Dorset-sire lambs. Aust. J. Agr. Res. 57:1-12.
12. Greenwood, P. L., G. E. Gardner, and R. S. Hegarty. 2006b. Lamb myofibre characteristics are influenced by sire estimated breeding values and pastoral nutritional systems. Aust. J. Agr. Res. 57:627-639.
13. Greenwood, P. L., S. Harden, and D. L. Hopkins. 2007. Myofibre characteristics of ovine longissimus and semitendinosus muscles are influenced by sire breed, gender, rearing type, age and carcass weight. Aust. J. Exp. Agr. 47:1137-1146.
14. Greenwood, P. L., R. M. Slepetis, J. W. Hermanson, and A. W. Bell. 1999. Intrauterine growth retardation is associated with reduced cell cycle activity, but not myofibre number, in ovine fetal muscle. Reprod. Fert. Develop. 11:281-291.
15. Grobet, L., L. J. Martin, D. Poncelet, D. Pirottin, B. Brouwers, J. Riquet, A. Schoeberlein, S. Dunner, F. Menissier, J. Massabanda, R. Fries, R. Hanset, and M. Georges. 1997. A deletion in the bovine myostatin gene causes the double muscled phenotype in cattle. Nat. Genet. 17:71-74.
16. Hadjipavlou, G., O. Matika, A. Clop, and S. C. Bishop. 2008. Two single nucleotide polymorphisms in the myostatin (GDF8) gene have significant association with muscle depth of commercial Charollais sheep. Anim. Genet. 39:346-353.
17. Haynes, F. E. M., P. L. Greenwood, M. B. McDonagh, and V. H. Oddy. 2012. Myostatin allelic status interacts with level of nutrition to affect growth, body composition and myofiber characteristics of lambs. J. Anim. Sci. In press (DOI: 10.2527/jas20114452).
18. Haynes, F. E. M., P. L. Greenwood, J. P. Siddell, M. B. McDonagh, and V. H. Oddy. 2010. Computer tomography software program 'Osirix' aids prediction of sheep body composition. Proc. Aust. Soc. Anim. Prod. 28:49.
19. Hickford, J. G. H., R. H. Forrest, H. Zhou, Q. Fang, J. Han, C. M. Frampton, and A. L. Horrell. 2010. Polymorphisms in the ovine myostatin gene (MSTN) and their association with growth and carcass traits in New Zealand Romney sheep. Anim. Genet. 41:64-72.
20. Hill, J. J., M. V. Davies, A. A. Pearson, J. H. Wang, R. M. Hewick, N. M. Wolfman, and Q. Yongchang. 2002. The myostatin propeptide and the follistatin-related gene are inhibortory binding proteins of myostatin in normal serum. J. Biol. Chem. 277:40735-40741.
21. Johnson, P. L., K. G. Dodds, W. E. Bain, G. J. Greer, N. J. McLean, R. J. McLaren, S. M. Galloway, T. C. van Stijn, and J. C. McEwan. 2009. Investigations into the GDF8 g+6273G-A polymorphism in New Zealand Texel sheep. J. Anim. Sci. 87:1856-1864.
22. Kambadur, R., M. Sharma, T. P. L. Smith, and J. J. Bass. 1997. Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Res. 7:910-16.
23. Kijas, J. W., R. McCulloch, J. E. Hocking Edwards, V. H. Oddy, S. H. Lee, and J. van der Werf. 2007. Evidence for multiple alleles effecting muscling and fatness at the Ovine GDF8 locus. BMC Genet. 8:80.
24. Lee, S. J. 2004. Regulation of muscle mass by myostatin. Annu. Rev. Cell Dev. Bi. 20:61-86.
25. Maier, A., J. C. McEwan, K. G. Dodds, D. A. Fischman, R. B. Fitzsimons, and A. J. Harris. 1992. Myosin heavy chain composition of single fibres and their origins and distribution in developing fascicles of sheep tibialis cranialis muscles. J. Muscle Res. Cell Motil. 13:551-572.
26. Masri, A. Y., N. R. Lambe, J. M. Macfarlane, S. Brotherstone, W. Haresign, and L. Bünger. 2011. Evaluating the effects of a single copy of a mutation in the myostatin gene (c.*1232 G > A) on carcass traits in crossbred lambs. Meat Sci. 87:412-418.
27. McFarlane, C., G. Z. Hui, W. Z. Wei Amanda, H. Y. Lau, S. Lokireddy, G. Xiaojia, V. Mouly, G. Butler-Browne, P. D. Gluckman, M. Sharma, and R. Kambadur. 2011. Human myostatin negatively regulates human myoblast growth and differentiation. Am. J. Cell. Physiol. 301:C195-C203.
28. McMahon, C. D., L. Popovic, F. Jeanplong, J. M. Oldham, S. P. Kirk, C. C. Osepchook, K. W. Y. Wong, M. Sharma, R. Kambadur, and J. J. Bass. 2003. Sexual dimorphism is associated with decreased expression of processed myostatin in males. Am. J. Physiol. Endocrinol. Metab. 284:E377-E381.
29. McPherron, A. C. 2010. Metabolic functions of myostatin and GDF11. Immunol. Endocr. Metab. Agents Med. Chem. 10:217-231.
30. McPherron, A. C., A. M. Lawler, and S. J. Lee. 1997. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 387:83-90.
31. Oldham, J. M., C. C. Osepchook, F. Jeanplong, S. J. Falconer, K. G. Matthews, J. V. Conaglen, D. F. Gerrard, H. K. Smith, R. J. Wilkins, J. J. Bass, and C. D. McMahon. 2009. The decrease in mature myostatin protein in male skeletal muscle is developmentally regulated by growth hormone. J. Physiol. 587.3:669-77.
32. Picard, B., M. P. Duris, and C. Jurie. 1998. Classification of bovine muscle fibres by different histochemical techniques. Histochem. J. 30:473-479.
33. Picard, B., L. Lefaucheur, C. Berri, and M. J. Duclos. 2002. Muscle fibre ontogenesis in farm animal species. Reprod. Nutr. Dev. 42:415-431.
34. Ren, H., L. Li, H. Su, L. Xu, C. Wei, L. Zhang, H. Li, W. Liu, and L. Du. 2011. Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumquin sheep. BMC Genomics 12:411.
35. Sharma M., R. Kambadur, K. G. Matthews, W. G. Somers, G. P. Devlin, J. V. Conaglen, P. J. Fowke, and J. J. Bass. 1999. Myostatin, a transforming growth factor-b superfamily member, is expressed in heartmuscle and is upregulated in cardiomyocytes after infarct. J. Cell Physiol. 180:1-9.
36. Thomas, M., B. Langley, C. Berry, M. Sharma, S. Kirk, J. Bass, and R. Kambadur. 2000. Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. J. Biol. Chem. 275:40235-40243.
37. Wegner, J., E. Albrecht, I. Fiedler, F. Teuscher, H. J. Papstein, and K. Ender. 2000. Growth-and breed-related changes of muscle fiber characteristics in cattle. J. Anim. Sci. 78:1485-1496.