Is extracapsular tumour spread a prognostic factor in patients with early breast cancer?

International Journal of Clinical Oncology

Volumn 18, Issue 4, 2013, Pages 607-613

  Dobi, Erion ^a,d   Bazan, Fernando ^a,d   Dufresne, Armelle ^a,d   Demarchi, Martin ^a,d   Villanueva, Cristian ^a,d   Chaigneau, Loic ^a,d   Montcuquet, Philipe ^a,d   Ivanaj, Arben ^b,d   Sautière, Jean Loup ^c,d   Maisonnette Escot, Yolande ^c,d   Cals, Laurent ^a,d   Algros, Marie Paule ^a,d   Woronoff, Anne Sophie ^a,d   Pivot, Xavier ^a,d  

^a UNIVERSITY HOSPITAL OF BESANÇON   (France)

^b UNIVERSITY HOSPITAL CENTER MOTHER TERESA   (Albania)

^c Hospital of Besancon   (France)

^d INSERM   (France)

Author keywords

Breast cancer; Disease Free Survival; Extracapsular spread; Overall Survival; Prognostic factors

Indexed keywords

ANTHRACYCLINE DERIVATIVE; AROMATASE INHIBITOR; ESTROGEN RECEPTOR; PROGESTERONE; PROGESTERONE RECEPTOR; TAMOXIFEN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER PATIENT; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL DECISION MAKING; EXTRACAPSULAR TUMOUR SPREAD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; ONCOLOGICAL PARAMETERS; PATIENT IDENTIFICATION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RETROSPECTIVE STUDY; TREATMENT OUTCOME; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; AXILLA; BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPH NODES; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECEPTORS, PROGESTERONE; RETROSPECTIVE STUDIES; TIME FACTORS;

EID: 84882608729     PISSN: 13419625     EISSN: 14377772     Source Type: Journal    
DOI: 10.1007/s10147-012-0439-z     Document Type: Article

References (31)

1. Zhou P, Recht A (2004) Young age and outcome for women with early-stage invasive breast cancer. Cancer 101:1264-1274
2. Rondeau V, Mathoulin-Pélissier S, Tanneau L et al (2010) Separate and combined analysis of successive dependent outcomes after breast-conservation surgery: recurrence, metastases, second cancer and death. BMC Cancer 10:697-706
3. Berg JW, Robbins GF (1966) Factors influencing the short and the long-term survival of breast cancer patients. Surg Gynecol Obstet 122:1311-1336
4. Katz A, Strom EA, Buchholz TA et al (2000) Locoregional recurrence patterns after mastectomy and doxorubicin-based chemotherapy: implications for postoperative irradiation. J Clin Oncol 18:2817-2827
5. Gruber G, Bonetti M, Nasi ML et al (2005) Prognostic value of extracapsular tumour spread for locoregional control in premenopausal patients with node-positive breast cancer treated with classical cyclophosphamide, methotrexate, and fluorouracil: long-term observations from International Breast Cancer Study Group Trial VI. J Clin Oncol 23:7089-7097
6. Fisher BJ, Perera FE, Cooke AL et al (1997) Extracapsular axillary node extension in patients receiving adjuvant systemic therapy: an indication for radiotherapy? Int J Radiat Oncol Biol Phys 38:551-559
7. Kahlert S, Boettcher B, Lebeau A, et al. (1999) Prognostic impact of extended extracapsular component in involved lymph nodes in primary breast cancer. Eur J Cancer 35:S89, (Abstr 292)
8. Leonard C, Corkill M, Tomkin J et al (1995) Are axillary recurrence and overall survival affected by axillary extranodal tumour extension in breast cancer? Implications for radiation therapy. J Clin Oncol 13:47-53
9. Ragaz J, Jackson SM, Le N et al (1997) Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 337:956-962
10. Hetelekidis S, Schnitt SJ, Silver B et al (2000) The significance of extracapsular extension of axillary lymph node metastases in early-stage breast cancer. Int J Radiat Oncol Biol Phys 46:31-34
11. Veronesi U, Rilke F, Luini A et al (1987) Distribution of axillary node metastases by level of invasion: an analysis of 539 cases. Cancer 59:682-687
12. Pierce LJ, Oberman HA, Strawderman MH et al (1995) Microscopic extracapsular extension in the axilla: is this an indication for axillary radiotherapy? Int J Radiat Oncol Biol Phys 33:253-259
13. Vicini FA, Horwitz EM, Lacerna MD et al (1997) The role of regional nodal irradiation in the management of patients with early-stage breast cancer treated with breast-conserving therapy. Int J Radiat Oncol Biol Phys 39:1069-1076
14. Fodor J, Toth J, Major T et al (1999) Incidence and time of occurrence of regional recurrence in stage I-II breast cancer: value of adjuvant irradiation. Int J Radiat Oncol Biol Phys 44:281-287
15. Jager JJ, Volovics L, Schouten LJ et al (1999) Loco-regional recurrences after mastectomy in breast cancer: prognostic factors and implications for postoperative irradiation. Radiother Oncol 50:267-275
16. Gruber G, Menzi S, Forster A et al (2005) Sites of failure in breast cancer patients with extracapsular invasion of axillary lymph node metastases, no need for axillary irradiation?! Strahenther Onkol 181:574-579
17. Fisher ER, Palekar AS, Gregorio RM et al (1976) Pathologic findings from the National Surgical Adjuvant Breast Project (protocol No. 4), III: the significance of extranodal extension of axillary metastases. Am J Clin Pathol 65:439-444
18. Mambo NC, Gallager S (1977) Carcinoma of the breast: the prognostic significance of extranodal extension of axillary disease. Cancer 39:2280-2285
19. Greene FL, Page DL, Fleming ID et al (2002) A.J.C.C. Cancer Staging Mannual, 6th ed. Springer, New York, pp 72-73
20. Kaplan E, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
21. Cox DR (1972) Regression models and lifetables. J R Stat Soc B 34:187-220
22. Brewster AM, Do KA, Thomson PA et al (2007) Relationship between epidemiologic risk factor and breast cancer recurrence. J Clin Oncol 25:4438-4444
23. Marchionni L, Wilson RF, Marinopoulos SS et al (2007) Impact of gene expression profiling tests on breast cancer outcomes. Evid Rep Technol Assess 160:1-105
24. Bucci JA, Kennedy CW, Burn J et al (2001) Implications of extranodal spread in node positive breast cancer: a review of survival and local recurrence. Breast 10:213-219
25. Brenner B, Siris S, Rakowsky E et al (2002) Prediction of outcome in locally advanced breast cancer by post-chemotherapy nodal status and baseline tumour markers. Br J Cancer 87:1404-1410
26. Neri A, Marrelli D, Roviello F et al (2005) Prognostic value of extracapsular extension of axillary lymph node metastases in T1 to T3 breast cancer. Ann Surg Oncol 12:246-253
27. Gruber G, Cole B, Castiglione-Gertsch M et al (2008) Extracapsular tumour spread and the risk of local, axillary and supraclavicular recurrence in node positive, premenopausal patients with breast cancer. Anals Oncology 19:1393-1401
28. Ceilley E, Jagsi R, Goldberg S (2005) Radiotherapy for invasive breast cancer in North America and Europe: results of a survey. Int J Radiat Oncol Biol Phys 61:365-373
29. Overgaard M, Hansen PS, Overgaard J et al (1997) Postoperative radiotherapy in high risk premenopausal women with breast cancer who receive adjuvant chemotherapy: Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 337:949-955
30. Overgaard M, Jensen MB, Overgaard J et al (1999) Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 353:1641-1648
31. Van den Eynden G, Vandenberghe M, Van Dam P et al (2007) Increased sentinel lymph node lymphangiogenesis is associated with nonsentinel axillary node involvement in breast cancer patients with a positive sentinel node. Clin Cancer Res 13:5391-5397