Evaluation of arginine metabolism for the analysis of M1/M2 macrophage activation in human clinical specimens

Inflammation Research

Volumn 62, Issue 9, 2013, Pages 865-869

  Geelhaar Karsch, Anika ^a,b   Schinnerling, Katina ^a,b   Conrad, Kristina ^a   Friebel, Julian ^a   Allers, Kristina ^a   Schneider, Thomas ^a   Moos, Verena ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Arginase activity; Macrophage function and differentiation; Nitrite detection; Whipple's disease

Indexed keywords

ARGINASE; CD14 ANTIGEN; CD163 ANTIGEN; NITRITE; UREA;

ADULT; AGED; AMINO ACID METABOLISM; ARTICLE; CELL DIFFERENTIATION; CELL LYSATE; CELL POLARIZATION; CELLULAR PARAMETERS; CONTROLLED STUDY; DUODENUM BIOPSY; ENZYME ACTIVITY; FEASIBILITY STUDY; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INTESTINE LIPODYSTROPHY; M1 MACROPHAGE; M2 MACROPHAGE; MACROPHAGE; MACROPHAGE ACTIVATION; MAJOR CLINICAL STUDY; MALE; SUPERNATANT;

EID: 84882579352     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-013-0642-z     Document Type: Article

References (15)

1. Martinez FO, Sica A, Mantovani A, Locati M. Macrophage activation and polarization. Front Biosci. 2008;13:453-61.
2. Benoit M, Desnues B, Mege JL. Macrophage polarization in bacterial infections. J Immunol. 2008;181:3733-9.
3. Pesce JT, Ramalingam TR, Mentink-Kane MM, Wilson MS, El Kasmi KC, Smith AM, et al. Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog. 2009;5:e1000371.
4. Bogdan C. Nitric oxide and the immune response. Nat Immunol. 2001;2:907-16.
5. Munder M, Eichmann K, Moran JM, Centeno F, Soler G, Modolell M. Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol. 1999;163:3771-7.
6. Mege JL, Mehraj V, Capo C. Macrophage polarization and bacterial infections. Curr Opin Infect Dis. 2011;24:230-4.
7. Amin AR, Attur M, Vyas P, Leszczynska-Piziak J, Levartovsky D, Rediske J, et al. Expression of nitric oxide synthase in human peripheral blood mononuclear cells and neutrophils. J Inflamm. 1995;47:190-205.
8. Wang WW, Jenkinson CP, Griscavage JM, Kern RM, Arabolos NS, Byrns RE, et al. Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide. Biochem Biophys Res Commun. 1995;210:1009-16.
9. Schneider T, Moos V, Loddenkemper C, Marth T, Fenollar F, Raoult D. Whipple's disease: new aspects of pathogenesis and treatment. Lancet Infect Dis. 2008;8:179-90.
10. Moos V, Schmidt C, Geelhaar A, Kunkel D, Allers K, Schinnerling K, et al. Impaired immune functions of monocytes and macrophages in Whipple's disease. Gastroenterology. 2010;138:210-20.
11. Horowitz S, Binion DG, Nelson VM, Kanaa Y, Javadi P, Lazarova Z, et al. Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1323-36.
12. Corraliza IM, Campo ML, Soler G, Modolell M. Determination of arginase activity in macrophages: a micromethod. J Immunol Methods. 1994;174:231-5.
13. Wei LH, Morris SM Jr, Cederbaum SD, Mori M, Ignarro LJ. Induction of arginase II in human Caco-2 tumor cells by cyclic AMP. Arch Biochem Biophys. 2000;374:255-60.
14. Albina JE. On the expression of nitric oxide synthase by human macrophages. Why no NO? J Leukoc Biol. 1995;58:643-9.
15. Boven LA, van Meurs M, Boot RG, Mehta A, Boon L, Aerts JM, et al. Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages. Am J Clin Pathol. 2004;122:359-69.