Effects of oral supplementation with glutamate or combination of glutamate and N-carbamylglutamate on intestinal mucosa morphology and epithelium cell proliferation in weanling piglets

Journal of Animal Science

Volumn 90, Issue SUPPL4, 2012, Pages 337-339

  Wu, X ^a   Zhang, Y ^a   Liu, Z ^a   Li, T J ^a   Yin, Y L ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Amino acids; Digestion; Pigs

Indexed keywords

BETA CATENIN; CYCLINE; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; N CARBAMYLGLUTAMATE; N-CARBAMYLGLUTAMATE; VASCULOTROPIN A;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; CELL PROLIFERATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOLOGY; DIET; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; ILEUM; INTESTINE MUCOSA; JEJUNUM; METABOLISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; REAL TIME POLYMERASE CHAIN REACTION; SWINE; WEANING;

ADMINISTRATION, ORAL; ANIMAL FEED; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; BETA CATENIN; CELL PROLIFERATION; DIET; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; GLUTAMATES; GLUTAMIC ACID; ILEUM; INTESTINAL MUCOSA; JEJUNUM; PROLIFERATING CELL NUCLEAR ANTIGEN; REAL-TIME POLYMERASE CHAIN REACTION; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WEANING;

EID: 84882568427     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.53752     Document Type: Article

References (10)

1. Burrin, D. G., and B. Stoll. 2009. Metabolic fate and function of dietary glutamate in the gut. Am. J. Clin. Nutr. 90:850S-856S.
2. Caldovic, L., N. Ah Mew, D. Shi, H. Morizono, M. Yudkoff, and M. Tuchman. 2010. N-acetylglutamate synthase: structure, function and defects. Mol. Genet. Metab. 100(Suppl.1):S13-19.
3. Frank, J. W., J. Escobar, H. V. Nguyen, S. C. Jobgen, W. S. Jobgen, T. A. Davis, and G. Wu. 2007. Oral N-carbamylglutamate supplementation increases protein synthesis in skeletal muscle of piglets. J. Nutr. 137:315-319.
4. NRC. 1998. Nutrient Requirements of Swine, 10th ed. National Academy Press, Washington, DC.
5. Reeds, P. J., D. G. Burrin, B. Stoll, and F. Jahoor. 2000. Intestinal glutamate metabolism. J. Nutr. 130:978S-982S.
6. Tuchman, M., L. Caldovic, Y. Daikhin, O. Horyn, I. Nissim, M. Korson, B. Burton, and M. Yudkoff. 2008. N-carbamylglutamate markedly enhances ureagenesis in N-acetylglutamate deficiency and propionic acidemia as measured by isotopic incorporation and blood biomarkers. Pediatr. Res. 64:213-217.
7. Walker, R., and J. R. Lupien. 2000. The safety evaluation of monosodium glutamate. J. Nutr. 130:1049S-1052S.
8. Watford, M., and P. J. Reeds. 2003. Glutamate metabolism in the gut. Forum Nutr. 56:81-82.
9. Wu, G., D. A. Knabe, and S. W. Kim. 2004. Arginine nutrition in neonatal pigs. J. Nutr. 134:2783S-2790S; discussion 2796S-2797S.
10. Wu, X., Z. Ruan, Y. Gao, Y. L. Yin, X. Zhou, L. Wang, M. Geng, Y. Hou, and G. Wu. 2010. Dietary supplementation with L-arginine or N-carbamylglutamate enhances intestinal growth and heat shock protein-70 expression in weanling pigs fed a corn-and soybean meal-based diet. Amino Acids 39:831-839.