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Volumn , Issue , 2007, Pages 1-33

Metabonomics and Metabolomics Techniques and Their Applications in Mammalian Systems

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EID: 84882555432     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-044452841-4/50002-3     Document Type: Chapter
Times cited : (27)

References (91)
  • 2
    • 0024946615 scopus 로고
    • High-resolution proton magnetic resonance spectroscopy of biological fluids
    • Nicholson J.K., Wilson I.D. High-resolution proton magnetic resonance spectroscopy of biological fluids. Prog. NMR Spectrosc. 1989, 21:449-501.
    • (1989) Prog. NMR Spectrosc. , vol.21 , pp. 449-501
    • Nicholson, J.K.1    Wilson, I.D.2
  • 4
    • 0025891393 scopus 로고
    • The application of pattern recognition methods to the analysis and classification of toxicological data derived from proton NMR spectroscopy of urine
    • Gartland K.P.R., Beddell C.R., Lindon J.C., Nicholson J.K. The application of pattern recognition methods to the analysis and classification of toxicological data derived from proton NMR spectroscopy of urine. Mol. Pharmacol. 1991, 39:629-642.
    • (1991) Mol. Pharmacol. , vol.39 , pp. 629-642
    • Gartland, K.P.R.1    Beddell, C.R.2    Lindon, J.C.3    Nicholson, J.K.4
  • 5
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson J.K., Lindon J.C., Holmes E. 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 1999, 29:1181-1189.
    • (1999) Xenobiotica , vol.29 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 7
    • 0036007687 scopus 로고    scopus 로고
    • Metabolics - the link between genotypes and phenotypes
    • Fiehn O. Metabolics - the link between genotypes and phenotypes. Plant Mol. Biol. 2002, 48:155-171.
    • (2002) Plant Mol. Biol. , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 8
    • 0043069547 scopus 로고    scopus 로고
    • Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
    • Nicholson J.K., Wilson I.D. Understanding 'global' systems biology: Metabonomics and the continuum of metabolism. Nature Rev. Drug Disc. 2003, 2:668-676.
    • (2003) Nature Rev. Drug Disc. , vol.2 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 10
    • 0027052705 scopus 로고
    • NMR spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression and recovery from nephrotoxic lesions in the rat induced by mercury II chloride and 2-bromoethanamine
    • Holmes E., Bonner F.W., Sweatman B.C., Lindon J.C., Beddell C.R., Rahr E., Nicholson J.K. NMR spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression and recovery from nephrotoxic lesions in the rat induced by mercury II chloride and 2-bromoethanamine. Mol. Pharmacol. 1992, 42:922-930.
    • (1992) Mol. Pharmacol. , vol.42 , pp. 922-930
    • Holmes, E.1    Bonner, F.W.2    Sweatman, B.C.3    Lindon, J.C.4    Beddell, C.R.5    Rahr, E.6    Nicholson, J.K.7
  • 11
    • 0037425743 scopus 로고    scopus 로고
    • Gut flora in health and disease
    • Guarner F., Malagelada J.R. Gut flora in health and disease. The Lancet 2003, 360:512-519.
    • (2003) The Lancet , vol.360 , pp. 512-519
    • Guarner, F.1    Malagelada, J.R.2
  • 14
    • 0037471164 scopus 로고    scopus 로고
    • The thin line between gut commensal and pathogen
    • Gilmore M.S., Ferretti J.J. The thin line between gut commensal and pathogen. Science 2003, 299:1999-2002.
    • (2003) Science , vol.299 , pp. 1999-2002
    • Gilmore, M.S.1    Ferretti, J.J.2
  • 15
    • 0030297089 scopus 로고    scopus 로고
    • The indigenous gastrointestinal microflora
    • Berg R.D. The indigenous gastrointestinal microflora. Trends Microbiol. 1996, 4:430-435.
    • (1996) Trends Microbiol. , vol.4 , pp. 430-435
    • Berg, R.D.1
  • 16
    • 0035340684 scopus 로고    scopus 로고
    • The meaning and impact of the human genome sequence for microbiology
    • Relman D.A., Falkow S. The meaning and impact of the human genome sequence for microbiology. Trends Microbiol. 2001, 9:206-208.
    • (2001) Trends Microbiol. , vol.9 , pp. 206-208
    • Relman, D.A.1    Falkow, S.2
  • 17
    • 0015030844 scopus 로고
    • The role of the intestinal flora in the metabolism of prontosil and neoprontosil in the rat
    • Gingell R., Bridges J.W., Williams R.T. The role of the intestinal flora in the metabolism of prontosil and neoprontosil in the rat. Xenobiotica 1971, 1:143-156.
    • (1971) Xenobiotica , vol.1 , pp. 143-156
    • Gingell, R.1    Bridges, J.W.2    Williams, R.T.3
  • 18
    • 0015355505 scopus 로고
    • Caffeic acid metabolism by bacteria of the human gastroin-testinal tract
    • Peppercorn M.A., Goldman P. Caffeic acid metabolism by bacteria of the human gastroin-testinal tract. Proc. Nat. Acad. Sci. USA 1972, 69:1413-1415.
    • (1972) Proc. Nat. Acad. Sci. USA , vol.69 , pp. 1413-1415
    • Peppercorn, M.A.1    Goldman, P.2
  • 20
    • 0031839564 scopus 로고    scopus 로고
    • Effect of diet on the urinary excretion of hippuric acid and other dietary derived aromatics in the rat. A complex interaction between the diet, intestinal microflora and substrate specificity
    • Phipps A.N., Stewart J., Wright B., Wilson I.D. Effect of diet on the urinary excretion of hippuric acid and other dietary derived aromatics in the rat. A complex interaction between the diet, intestinal microflora and substrate specificity. Xenobiotica 1998, 28:527-537.
    • (1998) Xenobiotica , vol.28 , pp. 527-537
    • Phipps, A.N.1    Stewart, J.2    Wright, B.3    Wilson, I.D.4
  • 22
    • 0345714918 scopus 로고    scopus 로고
    • NMR spectroscopic based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats
    • Nicholls A.W., Mortishire-Smith R.J., Nicholson J.K. NMR spectroscopic based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats. Chem. Res. Toxicol. 2003, 16:1395-1404.
    • (2003) Chem. Res. Toxicol. , vol.16 , pp. 1395-1404
    • Nicholls, A.W.1    Mortishire-Smith, R.J.2    Nicholson, J.K.3
  • 23
    • 0031935202 scopus 로고    scopus 로고
    • Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymes
    • Sheweita S.A., Mangoura S.A., Shemi A.G.El Different levels of Schistosoma mansoni infection induce changes in drug-metabolizing enzymes. J. Helminthol. 1998, 72:71-77.
    • (1998) J. Helminthol. , vol.72 , pp. 71-77
    • Sheweita, S.A.1    Mangoura, S.A.2    Shemi, A.3
  • 24
    • 0036181015 scopus 로고    scopus 로고
    • Changes in the expression of cytochrome P450 isoenzymes and related carcinogen metabolizing enzymes activities in Schistosoma mansoni-infected mice
    • Sheweita S.A., Mubark J., Doenhofe M.J., Mostafa M.H., Margison G.P., O'Connor P.J., Elder R.H. Changes in the expression of cytochrome P450 isoenzymes and related carcinogen metabolizing enzymes activities in Schistosoma mansoni-infected mice. J. Helminthol. 2002, 76:71-78.
    • (2002) J. Helminthol. , vol.76 , pp. 71-78
    • Sheweita, S.A.1    Mubark, J.2    Doenhofe, M.J.3    Mostafa, M.H.4    Margison, G.P.5    O'Connor, P.J.6    Elder, R.H.7
  • 27
    • 0035082791 scopus 로고    scopus 로고
    • P-hydroxyphenylacetate decarboxylase from Clostridium difficile: A novel glycyl radical enzyme catalysing the formation of p-cresol
    • Selmer T., Andrei P.I. p-hydroxyphenylacetate decarboxylase from Clostridium difficile: A novel glycyl radical enzyme catalysing the formation of p-cresol. Eur. J. Biochem. 2001, 268:1363-1372.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 1363-1372
    • Selmer, T.1    Andrei, P.I.2
  • 33
    • 0034775361 scopus 로고    scopus 로고
    • NMR and pattern recognition studies on the time-related metabolic effects of α-naphthylisothiocyanate on liver, urine and plasma in the rat: An integrative metabonomic approach
    • Waters N.J., Holmes E., Williams A., Waterfield C.J., Farrant R.D., Nicholson J.K. NMR and pattern recognition studies on the time-related metabolic effects of α-naphthylisothiocyanate on liver, urine and plasma in the rat: An integrative metabonomic approach. Chem. Res. Toxicol. 2001, 14:1401-1412.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 1401-1412
    • Waters, N.J.1    Holmes, E.2    Williams, A.3    Waterfield, C.J.4    Farrant, R.D.5    Nicholson, J.K.6
  • 34
    • 0036174751 scopus 로고    scopus 로고
    • Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data
    • Azmi J., Griffin J., Antti H., Shore R.F., Johansson E., Nicholson J.K., Holmes E. Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data. The Analyst 2002, 127:271-276.
    • (2002) The Analyst , vol.127 , pp. 271-276
    • Azmi, J.1    Griffin, J.2    Antti, H.3    Shore, R.F.4    Johansson, E.5    Nicholson, J.K.6    Holmes, E.7
  • 35
    • 2442651602 scopus 로고    scopus 로고
    • Geometric trajectory analysis of metabolic responses to toxicity can define treatment-specific profiles
    • Keun H.C., Bollard M., Beckonert O., Holmes E., Lindon J.C., Nicholson J.K. Geometric trajectory analysis of metabolic responses to toxicity can define treatment-specific profiles. Chem. Res. Toxicol. 2004, 17:579-587.
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 579-587
    • Keun, H.C.1    Bollard, M.2    Beckonert, O.3    Holmes, E.4    Lindon, J.C.5    Nicholson, J.K.6
  • 37
  • 38
    • 26244457653 scopus 로고    scopus 로고
    • Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism
    • Mayr M., Chung Y.L., Mayr U., Yin X.K., Ly L., Troy H., Fredericks S., Yu Y.H., Griffiths J.R., Xu Q.B. Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism. Arterioscl. Thromb. Vasc. Biol. 2005, 25:2135-2142.
    • (2005) Arterioscl. Thromb. Vasc. Biol. , vol.25 , pp. 2135-2142
    • Mayr, M.1    Chung, Y.L.2    Mayr, U.3    Yin, X.K.4    Ly, L.5    Troy, H.6    Fredericks, S.7    Yu, Y.H.8    Griffiths, J.R.9    Xu, Q.B.10
  • 40
    • 28044440100 scopus 로고    scopus 로고
    • Global metabolite analysis of yeast: Evaluation of sample preparation methods
    • Villas-Boas S.G., Hojer-Pedersen J., Akesson M., Smedsgaard J., Nielsen J. Global metabolite analysis of yeast: Evaluation of sample preparation methods. Yeast 2005, 22:1155-1169.
    • (2005) Yeast , vol.22 , pp. 1155-1169
    • Villas-Boas, S.G.1    Hojer-Pedersen, J.2    Akesson, M.3    Smedsgaard, J.4    Nielsen, J.5
  • 43
    • 0043282812 scopus 로고    scopus 로고
    • Functional genomics via metabolic footprinting: Monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry
    • Kaderbhai N.N., Broadhurst D.I., Ellis D.I., Kell D.B. Functional genomics via metabolic footprinting: Monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry. Comp. Funct. Genom. 2003, 4:376-391.
    • (2003) Comp. Funct. Genom. , vol.4 , pp. 376-391
    • Kaderbhai, N.N.1    Broadhurst, D.I.2    Ellis, D.I.3    Kell, D.B.4
  • 45
    • 0003550821 scopus 로고    scopus 로고
    • High-Resolution NMR Techniques in Organic Chemistry
    • Oxford, UK, ISBN: 0080427995.
    • T.D.W. Claridge, High-Resolution NMR Techniques in Organic Chemistry. Elsevier Science, Oxford, UK, pp. 384. ISBN: 0080427995.
    • Elsevier Science , pp. 384
    • Claridge, T.D.W.1
  • 49
    • 23644447752 scopus 로고    scopus 로고
    • Tissue targeted metabonomics: Metabolic profiling by microdialysis sampling and microcoil NMR
    • Price K.E., Vandaveer S.S., Lunte C.E., Larive C.K. Tissue targeted metabonomics: Metabolic profiling by microdialysis sampling and microcoil NMR. J. Pharmaceut. Biomed. Anal. 2005, 38:904-909.
    • (2005) J. Pharmaceut. Biomed. Anal. , vol.38 , pp. 904-909
    • Price, K.E.1    Vandaveer, S.S.2    Lunte, C.E.3    Larive, C.K.4
  • 52
    • 2642686624 scopus 로고    scopus 로고
    • Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens
    • Cheng L.L., Chang I.W., Louis D.N., Gonzalez R.G. Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens. Cancer Res. 1998, 58:1825-1832.
    • (1998) Cancer Res. , vol.58 , pp. 1825-1832
    • Cheng, L.L.1    Chang, I.W.2    Louis, D.N.3    Gonzalez, R.G.4
  • 53
    • 8844261879 scopus 로고    scopus 로고
    • Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases
    • Yang J., Xu G., Zheng Y., Kong H., Pang T., Lv S., Yang Q. Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases. J. Chromatogr., B 2004, 813:59-65.
    • (2004) J. Chromatogr., B , vol.813 , pp. 59-65
    • Yang, J.1    Xu, G.2    Zheng, Y.3    Kong, H.4    Pang, T.5    Lv, S.6    Yang, Q.7
  • 54
    • 22544463675 scopus 로고    scopus 로고
    • Focused metabolomic profiling in the drug development process: Advances from lipid profiling
    • Morris M., Watkins S.M. Focused metabolomic profiling in the drug development process: Advances from lipid profiling. Curr. Op. Chem. Biol. 2005, 9:407-412.
    • (2005) Curr. Op. Chem. Biol. , vol.9 , pp. 407-412
    • Morris, M.1    Watkins, S.M.2
  • 55
    • 17444404226 scopus 로고    scopus 로고
    • High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
    • Wilson I.D., Nicholson J.K., Castro-Perez J., Granger J.H., Johnson K.A., Smith B.W., Plumb R.S. High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J. Proteome Res. 2005, 4:591-598.
    • (2005) J. Proteome Res. , vol.4 , pp. 591-598
    • Wilson, I.D.1    Nicholson, J.K.2    Castro-Perez, J.3    Granger, J.H.4    Johnson, K.A.5    Smith, B.W.6    Plumb, R.S.7
  • 56
    • 0242569355 scopus 로고    scopus 로고
    • Quantitative metabolome analysis using capillary electrophoresis mass spectrometry
    • Soga T., Ohashi Y., Ueno Y., Nasaoka H., Tomita M., Nishioka T. Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. J. Proteome Res. 2003, 2:488-494.
    • (2003) J. Proteome Res. , vol.2 , pp. 488-494
    • Soga, T.1    Ohashi, Y.2    Ueno, Y.3    Nasaoka, H.4    Tomita, M.5    Nishioka, T.6
  • 57
    • 0034306770 scopus 로고    scopus 로고
    • Directly-coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development
    • Lindon J.C., Nicholson J.K., Wilson I.D. Directly-coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development. J. Chromatog., B 2000, 748:233-258.
    • (2000) J. Chromatog., B , vol.748 , pp. 233-258
    • Lindon, J.C.1    Nicholson, J.K.2    Wilson, I.D.3
  • 58
    • 0035796127 scopus 로고    scopus 로고
    • Pattern recognition methods and applications in biomedical magnetic resonance
    • Lindon J.C., Holmes E., Nicholson J.K. Pattern recognition methods and applications in biomedical magnetic resonance. Prog. NMR Spectrosc. 2001, 39:1-40.
    • (2001) Prog. NMR Spectrosc. , vol.39 , pp. 1-40
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 59
    • 0000781020 scopus 로고
    • Partial Least Squares
    • John Wiley & Sons, New York, USA, S. Kotz, N.L. Johnson (Eds.)
    • Wold H. Partial Least Squares. Encyclopedia of Statistical Sciences 1985, 6:581-591. John Wiley & Sons, New York, USA. S. Kotz, N.L. Johnson (Eds.).
    • (1985) Encyclopedia of Statistical Sciences , vol.6 , pp. 581-591
    • Wold, H.1
  • 60
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • Trygg J., Wold S. Orthogonal projections to latent structures (O-PLS). J. Chemonet. 2002, 16:119-128.
    • (2002) J. Chemonet. , vol.16 , pp. 119-128
    • Trygg, J.1    Wold, S.2
  • 61
    • 0035107971 scopus 로고    scopus 로고
    • Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks
    • Holmes E., Nicholson J.K., Tranter G. Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks. Chem. Res. Toxicol. 2001, 14:182-191.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 182-191
    • Holmes, E.1    Nicholson, J.K.2    Tranter, G.3
  • 62
    • 0036042222 scopus 로고    scopus 로고
    • Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules
    • Kell D.B. Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules. Mol. Biol. Rep. 2002, 29:237-241.
    • (2002) Mol. Biol. Rep. , vol.29 , pp. 237-241
    • Kell, D.B.1
  • 64
    • 30744443014 scopus 로고    scopus 로고
    • Statistical Heterospectroscop Y (SHY), a new approach to the integrated analysis of NMR and UPLC-MS datasets: Application in metabonomic toxicology studies
    • Crockford D.J., Holmes E., Lindon J.C., Plumb R.S., Zirah S., Bruce S.J., Rainville P., Stumpf C.L., Nicholson J.K. Statistical Heterospectroscop Y (SHY), a new approach to the integrated analysis of NMR and UPLC-MS datasets: Application in metabonomic toxicology studies. Anal. Chem. 2006, 78:363-371.
    • (2006) Anal. Chem. , vol.78 , pp. 363-371
    • Crockford, D.J.1    Holmes, E.2    Lindon, J.C.3    Plumb, R.S.4    Zirah, S.5    Bruce, S.J.6    Rainville, P.7    Stumpf, C.L.8    Nicholson, J.K.9
  • 67
    • 33745370063 scopus 로고    scopus 로고
    • Metabolomics standards workshop and the development of international standards for reporting metabolomics experimental results
    • Castle A.L., Fiehn O., Kaddurah-Daouk R., Lindon J.C. Metabolomics standards workshop and the development of international standards for reporting metabolomics experimental results. Briefings in Bioinformatics 2006, 7:159-165.
    • (2006) Briefings in Bioinformatics , vol.7 , pp. 159-165
    • Castle, A.L.1    Fiehn, O.2    Kaddurah-Daouk, R.3    Lindon, J.C.4
  • 68
    • 19144371287 scopus 로고    scopus 로고
    • NMR-based metabonomics approaches for evaluating physiological influences on biofluid composition
    • Bollard M.E., Stanley E.G., Lindon J.C., Nicholson J.K., Holmes E. NMR-based metabonomics approaches for evaluating physiological influences on biofluid composition. NMR Biomed. 2005, 18:143-162.
    • (2005) NMR Biomed. , vol.18 , pp. 143-162
    • Bollard, M.E.1    Stanley, E.G.2    Lindon, J.C.3    Nicholson, J.K.4    Holmes, E.5
  • 69
    • 21144435518 scopus 로고    scopus 로고
    • A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: Application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice
    • Plumb R.S., Granger J.H., Stumpf C.L., Johnson K.A., Smith B.W., Gaulitz S., Wilson I.D., Castro-Perez J. A rapid screening approach to metabonomics using UPLC and oa-TOF mass spectrometry: Application to age, gender and diurnal variation in normal/Zucker obese rats and black, white and nude mice. Analyst 2005, 130:844-849.
    • (2005) Analyst , vol.130 , pp. 844-849
    • Plumb, R.S.1    Granger, J.H.2    Stumpf, C.L.3    Johnson, K.A.4    Smith, B.W.5    Gaulitz, S.6    Wilson, I.D.7    Castro-Perez, J.8
  • 70
    • 0038050467 scopus 로고    scopus 로고
    • Genomics and metabolomics as markers for the interaction of diet and health: Lessons from lipids
    • German J.B., Roberts M.A., Watkins S.M. Genomics and metabolomics as markers for the interaction of diet and health: Lessons from lipids. J. Nutrition 2003, 133:2078S-2083S.
    • (2003) J. Nutrition , vol.133
    • German, J.B.1    Roberts, M.A.2    Watkins, S.M.3
  • 71
  • 74
    • 21444445989 scopus 로고    scopus 로고
    • 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamycin-induced nephrotoxicity in the rat
    • 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamycin-induced nephrotoxicity in the rat. Biomarkers 2005, 10:173-187.
    • (2005) Biomarkers , vol.10 , pp. 173-187
    • Lenz, E.M.1    Bright, J.2    Knight, R.3    Westwood, F.R.4    Davies, D.5    Major, H.6    Wilson, I.D.7
  • 81
    • 0037225665 scopus 로고    scopus 로고
    • Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism
    • Moolenaar S.H., Engelke U.F.H., Wevers R.A. Proton nuclear magnetic resonance spectroscopy of body fluids in the field of inborn errors of metabolism. Ann. Clin. Biochem. 2003, 40:16-24.
    • (2003) Ann. Clin. Biochem. , vol.40 , pp. 16-24
    • Moolenaar, S.H.1    Engelke, U.F.H.2    Wevers, R.A.3
  • 82
    • 28044450369 scopus 로고    scopus 로고
    • Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis
    • Coen M., O'Sullivan M., Bubb W.A., Kuchel P.W., Sorrell T. Proton nuclear magnetic resonance-based metabonomics for rapid diagnosis of meningitis and ventriculitis. Clin. Infect. Disease 2005, 41:1582-1590.
    • (2005) Clin. Infect. Disease , vol.41 , pp. 1582-1590
    • Coen, M.1    O'Sullivan, M.2    Bubb, W.A.3    Kuchel, P.W.4    Sorrell, T.5
  • 83
    • 14844336916 scopus 로고    scopus 로고
    • Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: A pattern-recognition H-1 NMR study
    • Dunne V.G., Bhattachayya S., Besser M., Rae C., Griffin J.L. Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: A pattern-recognition H-1 NMR study. NMR Biomed. 2005, 18:24-33.
    • (2005) NMR Biomed. , vol.18 , pp. 24-33
    • Dunne, V.G.1    Bhattachayya, S.2    Besser, M.3    Rae, C.4    Griffin, J.L.5


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