Transplantation Osteoporosis: Biochemical Correlates of Pathogenesis and Treatment

Dynamics of Bone and Cartilage Metabolism

Volumn , Issue , 2006, Pages 701-716

  Kulak, Carolina A Moreira ^a   Shane, Elizabeth ^b  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b Federal university of Parana ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84882552993     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088562-6/50043-1     Document Type: Chapter

References (145)

1. United Network of Organ Sharing (UNOS) http://www.unos.org.
2. Cohen A., Shane E. Transplantation osteoporosis. Curr. Opin. Endocrinol. Diab. 2001, 8:283-290.
3. Cohen A., Shane E. Osteoporosis after solid organ and bone marrow transplantation. Osteoporos. Int. 2003, 14:617-630.
4. Cohen A., Ebeling P., Sprague S., Shane E. Transplantation osteoporosis. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 2003, 370-379. American Society for Bone and Mineral Research, Washington, D.C. M.J. Favus (Ed.).
5. Movsowitz C., Epstein S., Fallon M., Ismail F., Thomas S. Cyclosporin A in vivo produces severe osteopenia in the rat: Effect of dose and duration of administration. Endocrinol. 1988, 123:2571-2577.
6. Movsowitz C., Epstein S., Ismail F., Fallon M., Thomas S. Cyclosporin A in the oophorectomized rat: Unexpected severe bone resorption. J. Bone Miner. Res. 1989, 4:393-398.
7. Schlosberg M., Movsowitz C., Epstein S., Ismail F., Fallon M.D., Thomas S. The effects of cyclosporin A administration and its withdrawal on bone mineral metabolism in the rat. Endocrinol. 1989, 124:2179-2184.
8. Stein B., Halloran P., Reinhardt T., Engstrom G.W., Bales C.W., Drezner M.K., Currie K.L., Takizawa M., Adams J.S., Epstein S. Cyclosporin A increases synthesis of 1,25 dihydroxyvitamin D3 in the rat and mouse. Endocrinol. 1991, 128:1369-1373.
9. Stein B., Takizawa M., Katz I., Berlin J., Joffe I., Fallon M., Epstein S. Salmon calciton in prevents cyclosporin A induced high turnover bone loss. Endocrinol. 1991, 129:92-98.
10. Sass D.A., Bowman A.R., Marshall I., Yuan Z., Ma Y.F., Jee W.S.S., Epstein S. Alendronate prevents cyclosporin-induced osteopenia in the rat. Bone 1997, 21:65-70.
11. Cvetkovic M., Mann G.N., Romero D.F., Liang X., Ma F., Jee W.S.S., Epstein S. The deleterious effects of long term cyclosporin A, cyclosporin G and FK506 on bone mineral metabolism in vivo. Transplantation 1994, 57:1231-1237.
12. Goodman W.G., Coburn J.W., Slatopolsky E., Salusky I.B., Quarles L.D. Renal osteodystrophy in adults and children. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 2003, 430-447. American Society for Bone and Mineral Research, Washington, DC. M. Favus (Ed.).
13. Schwarz C., Bohmig G.A., Steininer R., Mayer G., Oberbauer R. Impaired phosphate handling of renal allografts is aggravated under rapamycin-based immunosuppression. Nephrol. Dial. Transplant. 2001, 16:378-382.
14. Green J., Debby H., Lederer E., Levi M., Zajicek H.K., Bick T. Evidence for a PTH-independent humoral mechanism in post-transplant hypophosphatemia and phosphaturia. Kidney Int. 2001, 60:1182-1196.
15. Caravaca F., Fernandez M.A., Ruiz-Calero R., Cubero J., Aparicio A., Jimenez F., Garcia M.C. Effects of oral phosphorus supplementation on mineral metabolism of renal transplant recipients. Nephrol. Dial. Transplant. 1998, 13:2605-2611.
16. Almond M.K., Kwan J.T.C., Evans K., Cunningham J. Loss of regional bone mineral density in the first 12 months following renal transplantation. Nephron. 1994, 66:52-57.
17. Julian B.A., Laskow D.A., Dubovsky J., Dubovsky E.V., Curtis J.J., Quarrles L.D. Rapid loss of vertebral bone density after renal transplantation. N. Engl. J. Med. 1991, 325:544-550.
18. Kwan J.T.C., Almond M.K., Evans K., Cunningham J. Changes in total body bone mineral content and regional bone mineral density in renal patients following renal transplantation. Miner. Electrolyte Metab. 1992, 18:166-168.
19. Horber F.F., Casez J.P., Steiger U., Czerniack A., Montandon A., Jaeger P.H. Changes in bone mass early after kidney transplantation. J. Bone Miner. Res. 1994, 9:1-9.
20. Bagni B., Gilli P., Cavallini A., Bagni I., Marzola M.C., Orzincolo C., Wahner H.W. Continuing loss of vertebral mineral density in renal transplant recipients. Eur. J. Nucl. Med. 1994, 21:108-112.
21. Massari P.U., Garay G., Ulla M.R. Bone mineral content in cyclosporine-treated renal transplant patients. Transplant Proc. 1994, 26:2646-2648.
22. Kalef-Ezra J.A., Karantanas A.H., Hatzikonstantnou I., Sferopoulos G., Glaros D.K., Siampoulos K.C. Bone mineral status after renal transplantation. Invest. Radiol. 1994, 29:127-133.
23. Grotz W.H., Mundinger F.A., Gugel B., Exner V.M., Kirste G., Schollmeyer P.J. Bone mineral density after kidney transplantation. Transplantation 1995, 59:982-986.
24. Pichette V., Bonnardeaux A., Prudhomme L., Gagne M., Cardinal J., Ouimet D. Long-term bone loss in kidney transplant recipients: A cross-sectional and longitudinal study. Am. J. Kidney Dis. 1996, 28:105-114.
25. Boot A.M., Nauta J., Hokken-Koelega A.C.S., Pols H.A.P., Ridder M.A.J., Keizer-Schrama S.M.P.F. Renal transplantation and osteoporosis. Arch. Dis. Child. 1995, 72:502-506.
26. Cohen A., Shane E. Osteoporosis after solid organ and bone marrow transplantation. Osteoporos. Int. 2003, 14:617-630.
27. Cruz D.N., Wysolmerski J.J., Brickel H.M., Gundberg C.G., Simpson C.A., Mitnick M.A., Kliger A.S., Lorber M.I., Basadonna G.P., Friedman A.L., Insogna K.L., Bia M.J. Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study. Transplantation 2001, 72:83-88.
28. Farmer C.K.T., Hampson G., Vaja S., Abbs I.C., Hilton R.M., Koffman G., Watkins J., Sacks S.H., Fogelman I. Late low dose steroid withdrawal in renal transplant recipients increases bone formation and bone mineral density without altering renal function: a randomized controlled trial. J. Bone Miner: Res. 2002, 17:S158.
29. Hurst G., Alloway R., Hathaway D., Somerville T., Hughes T., Gaber A. Stabilization of bone mass after renal transplant with preemptive care. Transplant Proc. 1998, 30:1327-1328.
30. Moreno A., Torregrosa J.V., Pons F., Campistol J.M., Martinez de Osaba M.J., Oppenheimer F. Bone mineral density after renal transplantation: long-term follow-up. Transplant Proc. 1999, 31:2322-2323.
31. Nowacka-Cieciura E., Durlik M., Cieciura T., Lewandowska D., Baczkowska T., Kukula K., Lao M., Szmidt J., Rowinski W. Steroid withdrawal after renal transplantation-risks and benefits. Transplant Proc. 2002, 34:560-563.
32. Cueto-Manzano A.M., Konel S., Freemont A.J., Adams J.E., Mawer B., Gokal R., Hutchison A.J. Effect of 1,25-dihydroxyvitamin D3 and calcium carbonate on bone loss associated with long-term renal transplantation. Am. J. Kid. Dis. 2000, 35:227-236.
33. Grotz W.H., Mundinger A., Gugel B., Exner V., Kirste G., Schollmeyer P.J. Bone fracture and osteodensitometry with dual energy x-ray absorptiometry in kidney transplant recipients. Transplantation 1994, 58:912-915.
34. Nisbeth U., Lindh E., Ljunghall S., Backman U., Fellstrom B. Fracture frequency after kidney transplantation. Transplant Proc. 1994, 26:1764.
35. Nisbeth U., Lindh E., Ljunghall S., Backman U., Fellstrom B. Increased fracture rate in diabetes mellitus and females after renal transplantation. Transplantation 1999, 67:1218-1222.
36. Smets Y.F., van der Pijl J.W., de Fijter J.W., Ringers J., Lemkes H.H., Hamdy N.A. Low bone mass and high incidence of fractures after successful simultaneous pancreas-kidney transplantation. Nephrol. Dial. Transplant. 1998, 13:1250-1255.
37. Chiu M.Y., Sprague S.M., Bruce D.S., Woodle E.S., Thistlethwaite J.R., Josephson M.A. Analysis of fracture prevalence in kidney-pancreas allograft recipients. J. Am. Soc. Nephrol. 1998, 9:677-683.
38. Ramsey-Goldman R., Dunn J.E., Dunlop D.D., Stuart F.P., Abecassis M.M., Kaufman D.B., Langman C.B., Salinger M.H., Sprague S.M. Increased risk of fracture in patients receiving solid organ transplants. J. Bone Miner. Res. 1999, 14:456-463.
39. Ball A.M., Gillen D.L., Sherrard D., Weiss N.S., Emerson S.S., Seliger S.L., Kestenbaum B.R., Stehman-Breen C. Risk of hip fracture among dialysis and renal transplant recipients. JAMA 2002, 288:3014-3018.
40. Delmas P.D., Wilson D.M., Mann K.G., Riggs B.L. Effect of renal function on plasma levels of bone Gla-protein. J. Clin. Endocrinol. Metab. 1983, 57:1028-1030.
41. Briner V.A., Thiel G., Monier-Faugere M.-C., Bognar B., Landmann J., Kamber V., Malluche H. Prevention of cancellous of bone loss but persistence of renal bone disease despite normal 1,25 vitamin D levels two years after kidney transplantation. Transplantation 1995, 59:1393-1400.
42. Boiskin I., Epstein S., Ismail F., Thomas S.B., Raja R. Serum osteocalcin and bone mineral metabolism following successful renal transplantation. Clin. Nephrol. 1989, 31:316-322.
43. Pietschmann P., Vychtil A., Woloszczuk W., Kovaril J. Bone metabolism in patients with functioning kidney grafts: increased serum levels of osteocalcin and parathyroid hormone despite normalization of kidney function. Nephron. 1991, 59:533-536.
44. Withold W., Degenhard S., Castelli D., Heins M., Grabensee B. Monitoring of osteoblast activity with an immunoradiometric assay for determination of bone alkaline phosphatase mass concentration in patients receiving renal transplants. Clin. Chim. Acta. 1994, 225:137-146.
45. Withold W., Degenhard S., Grabensee B., Reinauer H. Comparison between serumlevels of bone alkaline phosphatase and the carboxy-terminal propeptide of type 1 procollagen as markers of bone formation in patients following renal transplantation. Clin. Chim. Acta. 1995, 239:143-151.
46. Hamdy N.A.T., Risteli J., Risteli L., Harris S., Beneton M.N., Brown C.B., Kanis J.A. Serum type 1 procollagen peptide: a non-invasive index of bone formation in patients on haemodialysis?. Nephrol. Dial. Transplant 1994, 9:511-516.
47. Coen G., Mazzafero S., Ballanti P., Bonucci E., Bondatti F., Manni M., Pasquali M., Perruzza I., Sardella D., Spurio A. Procollagen type 1 C-terminal extension peptide in predialysis chronic renal failure. Am. J. Nephrol. 1992, 12:242-251.
48. Gonzalez M.T., Bonnin R., Cruzado J.M., Garcia R., Moreso F., Fulladosa X., Alsina J.A., Navarro M., Grino J.M. Course of three biochemical bone markers after kidney transplantation. Transplant Proc. 1995, 27:2266-2271.
49. Lechleitner P., Krimbacher E., Genser N., Fridrich L., zur Nedden D., Helweg G., Koenig P., Joannidis M. Bone mineral densitometry in dialyzed patients: quantitative computed tomography versus dual photon absorptiometry. Bone 1994, 15:387-391.
50. Rambausek M., Ritz E., Pomer S., Mohring K., Rohl L. Alkaline phosphatase levels in renal transplant recipients receiving cyclosporine or azathioprine/steroids. Lancet 1988, 1:247.
51. Aubia J., Masramon J., Serrano S. Bone histology in renal patients receiving cyclosporin. Lancet 1988, 1:1048.
52. Wilmink J.M., Bras J., Surachno S., Heyst J.L.A.M., Horst J.M.V. Bone repair in cyclosporine treated renal transplant patients. Transplant Proc. 1989, 21:1492-1494.
53. Dumoulin G., Hory B., Nguyen N.U., Henriet M.-T., Bresson C., Regnard J., Saint-Hillier Y. Lack of evidence that cyclosporine treatment impairs calcium-phosphorus homeostasis and bone remodeling in normocalcemic long-term renal transplant recipients. Transplantation 1995, 59:1690-1694.
54. Amado J.A., Riancho J.A., Francisco A.L.M.D., Cotorruelo J.G., Feijanes J., Arias M., Napal J., Gonzalez-Macias J. Hyperparathyroidism is responsible for the increased levels of osteocalcin in patients with normally functioning kidney grafts. Kidney Int. 1996, 50:1726-1733.
55. Lee A.H., Mull R.L., Keenan G.F., Callegari P.E., Dalinka M.K., Eisen H.J., Manicini D.M., DiSesa V.J., Attie M.F. Osteoporosis and bone morbidity in cardiac transplant recipients. Am. J. Med. 1994, 96:35-41.
56. Muchmore J.S., Cooper D.K.C., Ye Y., Schlegel V.J., Zudhi N. Loss of vertebral bone density in heart transplant patients. Transplant Proc. 1991, 23:1184-1185.
57. Shane E., Mancini D., Aaronson K., Silverberg S.J., Seibel M.J., Addesso V., McMahon D.J. Bone mass, vitamin D deficiency and hyperparathyroidism in congestive heart failure. Am. J. Med. 1997, 103:197-207.
58. Shane E., Addesso V., Namerow P., McMahon D., Lo S., Staron R., Zucker M., Pardi S., Maybaum S., Mancini D. Alendronate versus calcitriol for the prevention of bone loss after cardiac transplantation. New Engl. J. Med. 2004, 350:767-776.
59. Rich G.M., Mudge G.H., Laffel G.L., LeBoff M.S. Cyclosporine A and prednisone-associated osteoporosis in heart transplant recipients. J. Heart Lung Transplant 1992, 11:950-958.
60. Leidig-Bruckner G., Hosch S., Dodidou P., Ritchel D., Conradt C., Klose C., Otto G., Lange R., Theilmann L., Zimmerman R., Pritsch M., Zeigler R. Frequency and predictors of osteoporotic fractures after cardiac or liver transplantation: a follow-up study. Lancet. 2001, 357:342-347.
61. Sambrook P.N., Kelly P.J., Keogh A., Macdonald P., Spratt P., Freund J., Eisman J.A. Bone loss after cardiac transplantation: a prospective study. J. Heart Lung Transplant 1994, 13:116-121.
62. Shane E., Rivas M., Staron R.B., Silverberg S.J., Seibel M., Kuiper J., Mancini D., Addesso V., Michler R.E., Factor-Litvak P. Fracture after cardiac transplantation: A prospective longitudinal study. J. Clin. Endocrinol. Metab. 1996, 81:1740-1746.
63. Shane E., Rivas M., McMahon D.J., Staron R.B., Silverberg S.J., Seibel M.J., Mancini D., Michler R., Aaronson K., Addesso V., Lo S.H. Bone loss and tumover after cardiac transplantation. J. Clin. Endocrinol. Metab. 1997, 82:1497-1506.
64. Van Cleemput J., Daenen W., Nijs J., Geusens P., Dequeker J., Vanhaecke J. Timing and quantification of bone loss in cardiac transplant recipients. Transpl. Int. 1995, 8:196-200.
65. Berguer D.G., Krieg M.A., Thiebaud D., Burckhardt P., Stumpe F., Hurni M., Sadeghi H., Kappenberger L., Goy J.J. Osteoporosis in heart transplant recipients: a longitudinal study. Transplant Proc. 1994, 26:2649-2651.
66. Henderson N.K., Sambrook P.N., Kelly P.J., Macdonald P., Keogh A.M., Spratt P., Eisman J.A. Bone mineral loss and recovery after cardiac transplantation [letter]. Lancet 1995, 346:905.
67. Sambrook P.N., Kelly P.J., Fontana D., Nguyen T., Keogh A., Macdonald D., Spratt P., Freund J., Eisman J.A. Mechanisms of rapid bone loss following cardiac transplantation. Osteoporosis. Int. 1994, 4:273-276.
68. Thiebaud D., Krieg M., Gillard-Berguer D., Jaquet A., Goy J., Burckhardt P. Cyclosporine induces high tumover and may contribute to bone loss after heart transplantation. Eur. J. Clin. Invest. 1996, 26:549-555.
69. Prummel M.F., Wiersinga W.M., Lips P., Sanders G.T.P., Sauerwein H.P. The course of biochemical parameters of bone turnover during treatment with corticosteroids. J. Clin. Endocrinol. Metab. 1991, 72:382-386.
70. Lems W.F., Gerrits M.I., Jacobs J.W.G., Vugt R.M.V., Rijn H.J.M.V., Bijlsma J.W.J. Changes in (markers of) bone metabolism during high dose corticosteroid pulse treatment in patients with rheumatoid arthritis. Ann. Rheum. Dis. 1996, 55:288-293.
71. Guo C., Johnson A., Locke T., Eastell R. Mechanism of bone loss after cardiac transplantation. Bone 1998, 22:267-271.
72. Monegal A., Navasa M., Guanabens N., Peris P., Pons F., Osaba M.J.M.D., Rimola A., Rodes J., Munoz-Gomez J. Osteoporosis and bone mineral metabolism in cirrhotic patients referred for liver transplantation. Calcif. Tissue Int. 1997, 60:148-154.
73. Ninkovic M., Love S.A., Tom B., Alexander G.J., Compston J.E. High prevalence of osteoporosis in patients with chronic liver disease prior to liver transplantation. Calcif. Tissue Int. 2001, 69:321-326.
74. Hodgson S.F., Dickson E.R., Wahner H.W., Johnson K.A., Mann K.G., Riggs B.L. Bone loss and reduced osteoblast function in primary biliary cirrhosis. Ann. Int. Med. 1980, 103:855-860.
75. Guanabens N., Pares A., Alvarez L., Osaba M.J.M.D., Monegal A., Peris P., Ballesta A.M., Rodes J. Collagen-related markers of bone turnover reflect the severity of liver fibrosis in patients with primary biliary cirrhosi. J. Bone Miner. Res. 1998, 13:731-738.
76. Guanabens N., Pares A., Marinoso L., Brancos M.A., Piera C., Serrano S., Rivera F., Rodes J. Factors influencing the development of metabolic bone disease in primary biliary cirrhosis. Am. J. Gastroenterol. 1990, 85:1356-1362.
77. Hodgson S.F., Dickson E.R., Eastell R., Eriksen E.F., Bryant S.C., Riggs B.L. Rates of cancellous bone remodeling and turnover in osteopenia associated with primary biliary cirrhosis. Bone 1993, 14:819-827.
78. Vedi J., Greer S., Skingle S., Garrahan N., Ninkovic M., Alexander G., Compston J. Mechanism of bone loss after liver transplantation: A histomorphometric analysis. J. Bone Miner. Res. 1999, 14:281-287.
79. Janes C.H., Dickson E.R., Okazaki R., Bonde S., McDonagh A.F., Riggs B.L. Role of hyperbilirubinemia in the impairment of osteoblast proliferation associated with cholestatic jaundice. J. Clin. Invest. 1995, 95:2581-2586.
80. Haagsma E.B., Thijn C.J.P., Post J.G., Slooff M.J.H., Gisp C.H. Bone disease after liver transplantation. J. Hepatol. 1988, 6:94-100.
81. Arnold J.C., Hauser R., Ziegler R., Kommerelli B., Otto G., Theilmann L., Wuster C. Bone disease after liver transplantation. Transplant Proc. 1992, 24:2709-2710.
82. McDonald J.A., Dunstan C.R., Dilworth P., Sherbon K., Sheil A.G.R., Evans R.A., McCaughan G.W. Bone loss after liver transplantation. Hepatology 1991, 14:613-619.
83. Naiker I.P., Govender S., Naicker S., Dawood S., Haffejee A.A., Seedat Y.K. Avascular necrosis of bone following renal transplantation. S. Afr. Med. J. 1993, 83:646-649.
84. Eastell R., Dickson R.E., Hodgson S.F., Wiesner R.H., Porayko M.K., Wahner H.W., Cedel S.L., Riggs B.L., Krom R.A.F. Rates of vertebral bone loss before and after liver transplantation in women with primary biliary cirrhosis. Hepatology 1991, 14:296-300.
85. Meys E., Fontanges E., Fourcade N., Thomasson A., Pouyet M., Delmas P. Bone loss after orthotopic liver transplantation. Am. J. Med. 1994, 97:445-450.
86. Navasa M., Monegal A., Guanabens N., Peris P., Rimola A., Munoz-Gomez J., Visa J., Rodes J. Bone fractures in liver transplant patients. Brit. J. Rheumatol. 1994, 33:52-55.
87. Ninkovic M., Love S., Tom B.D., Bearcroft P.W., Alexander G.J., Compston J.E. Lack of effect of intravenous pamidronate on fracture incidence and bone mineral density after orthotopic liver transplantation. J. Hepatol. 2002, 37:93-100.
88. Compston J., Greer S., Skingle S., Stirling D., Price C., Friend P., Alexander G. Early increase in plasma parathyroid hormone level following liver transplantation. J. Hepatol. 1996, 25:715-718.
89. Hawkins F.G., Leon M., Lopez M.B., Valero M.A., Larrodera L., Garcia-Garcia I., Loinaz C., Gonzales E.M. Bone loss and turnover in patients with liver transplantation. Hepato-Gastroenterol. 1994, 41:158-161.
90. Valero M., Loinaz C., Larrodera L., Leon M., Morena E., Hawkins F. Calcitonin and bisphosphonate treatment in bone loss after liver transplantation. Calcif. Tissue Int. 1995, 57:15-19.
91. Rabinowitz M., Shapiro J., Lian J., Bloch G.D., Merkel I.S., Thiel D.H.V. Vitamin D and osteocalcin levels in liver transplant recipients. Is osteocalcin a reliable marker of bone turnover in such cases?. J. Hepatol. 1992, 16:50-55.
92. Watson R.G., Coulton L., Kanis J.A., Lombard M., Williams R., Neuberger J., Elias E. Circulating osteocalcin in primary biliary cirrhosis following liver transplantation and during treatment with ciclosporin. J. Hepatol. 1990, 11:354-358.
93. Abdelhadi M., Eriksson S.A., Ljusk Eriksson S., Ericzon B.G., Nordenstrom J. Bone mineral status in end-stage liver disease and the effect of liver transplantation. Scand. J. Gastroenterol. 1995, 30:1210-1215.
94. Aris R., Neuringer I., Weiner M., Egan T., Ontjes D. Severe osteoporosis before and after lung transplantation. Chest 1996, 109:1176-1183.
95. Shane E., Silverberg S.J., Donovan D., Papadopoulos A., Staron R.B., Addesso V., Jorgensen B., McGregor C., Shulman L. Osteoporosis in lung transplantation candidates with end stage pulmonary disease. Am. J. Med. 1996, 101:262-269.
96. Tschopp O., Boehler A., Speich R., Weder W., Seifert B., Russi E.W., Schmid C. Osteoporosis before lung transplantation: association with low body mass index, but not with underlying disease. Am. J. Transplant. 2002, 2:167-172.
97. Aris R.M., Renner J.B., Winders A.D., Buell H.E., Riggs D.B., Lester G.E., Ontjes D.A. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann. Intern. Med. 1998, 128:186-193.
98. Bachrach L.K., Loutit C.W., Moss R.B. Osteopenia in adults with cystic fibrosis [see comments]. Am. J. Med. 1994, 96:27-34.
99. Donovan D.S., Papadopoulos A., Staron R.B., Addesso V., Schulman L., McGregor C., Cosman F., Lindsay R.L., Shane E. Bone mass and vitamin D deficiency in adults with advanced cystic fibrosis lung disease. Am. J. Respir. Crit. Care Med. 1998, 157:1892-1899.
100. Grey A.B., Ames R.W., Matthews R.D., Reid I.R. Bone mineral density and body composition in adult patients with cystic fibrosis [see comments]. Thorax 1993, 48:589-593.
101. Aringer M., Kiener H., Koeller M., Artemiou O., Zuckerman A., Wieselthaler G., Klepetko W., Seidl G., Kainberger F., Barnecker P., Smolen J., Pietschmann P. High turnover bone disease following lung transplantation. Bone 1998, 23:485-488.
102. Ferrari S.L., Nicod L.P., Hamacher J., Spiliopoulos A., Slosman D.O., Rochat T., Bonjour J.-P., Rizzoli R. Osteoporosis in patients undergoing lung transplantation. Eur. Respir J. 1996, 9:2378-2382.
103. Shane E., Papadopoulos A., Staron R.B., Addesso V., Donovan D., McGregor C., Schulman L.L. Bone loss and fracture after lung transplantation. Transplantation 1999, 68:220-227.
104. Spira A., Gutierrez C., Chaparro C., Hutcheon M.A., Chan C.K. Osteoporosis and lung transplantation: a prospective study. Chest 2000, 117:476-481.
105. Trombetti A., Gerbase M.W., Spiliopoulos A., Slosman D.O., Nicod L.P., Rizzoli R. Bone mineral density in lung-transplant recipients before and after graft: prevention of lumbar spine post-transplantation-accelerated bone loss by pamidronate. J. Heart Lung Transplant. 2000, 19:736-743.
106. Schulte C., Beelen D., Schaefer U., Mann K. Bone loss in long-term survivors after transplantation of hematopoietic stem cells: a prospective study. Osteoporos. Int. 2000, 11:344-353.
107. Stern J.M., Chesnut C.H., Bruemmer B., Sullivan K.M., Lenssen P.S., Aker S.N., Sanders J. Bone density loss during treatment of chronic GVHD. Bone Marrow Transplant 1996, 17:395-400.
108. Ebeling P., Thomas D., Erbas B., Hopper L., Szer J., Grigg A. Mechanism of bone loss following allogeneic and autologous hematopoeitic stem cell transplantation. J. Bone Miner. Res. 1999, 14:342-350.
109. Kang M.I., Lee W.Y., Oh K.W., Han J.H., Song K.H., Cha B.Y., Lee K.W., Son H.Y., Kang S.K., Kim C.C. The shortterm changes of bone mineral metabolism following bone marrow transplantation. Bone 2000, 26:275-279.
110. Valimaki M., Kinnunen K., Volin L., Tahtela R., Loyttniemi E., Laitinen K., Makela P., Keto P., Ruutu T. A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin. Bone Marrow Transplant. 1999, 23:355-361.
111. Lee W.Y., Cho S.W., Oh E.S., Oh K.W., Lee J.M., Yoon K.H., Kang M.I., Cha B.Y., Lee K.W., Son H.Y., Kang S.K., Kim C.C. The effect of bone marrow transplantation on the osteoblastic differentiation of human bone marrow stromal cells. J. Clin. Endocrinol. Metab. 2002, 87:329-335.
112. Carlson K., Simonsson B., Ljunghall S. Acute effects of high dose chemotherapy followed by bone marrow transplantation on serum markers of bone metabolism. Calcif. Tissue Int. 1994, 55:408-411.
113. Tauchmanova L., Serio B., Del Puente A., Risitano A.M., Esposito A., De Rosa G., Lombardi G., Colao A., Rotoli B., Selleri C. Long-lasting bone damage detected by dual-energy x-ray absorptiometry, phalangeal osteosonogrammetry, and in vitro growth of marrow stromal cells after allogeneic stem cell transplantation. J. Clin. Endocrinol. Metab. 2002, 87:5058-5065.
114. Lien D., Jackson K., Monkhouse P., Halenar J., Mullen J., Winton T., Modry D., Siminoski K. Intervention prevents progression of osteoporosis in patients awaiting lung transplantation. J. Heart Lung Transplant. 2001, 20:225.
115. Fan S.L., Cunningham J. Bisphosphonates in renal osteodystrophy. Curr. Opin. Nephrol. Hypertens. 2001, 10:581-588.
116. Braith R.W., Mills J., Welsch M.A., Keller J.W., Pollack M.L. Resistance exercise training restores bone mineral density in heart transplant recipients. J. Am. Coll. Cardiol. 1996, 28:1471-1477.
117. Braith R.W., Magyari P.M., Fulton M.N., Aranda J., Walker T., Hill J.A. Resistance exercise training and alendronate reverse glucocorticoid-induced osteoporosis in heart transplant recipients. J. Heart Lung Transplant. 2003, 22:1082-1090.
118. Mitchell M.J., Baz M.A., Fulton M.N., Lisor C.F., Braith R.W. Resistance training prevents vertebral osteoporosis in lung transplant recipients. Transplantation 2003, 76:557-562.
119. Valimaki M.J., Kinnunen K., Tahtela R., Loyttyniemi E., Laitinen K., Makela P., Keto P., Nieminen M. A prospective study of bone loss and turnover after cardiac transplantation: effect of calcium supplementation with or without calcitonin. Osteoporos. Int. 1999, 10:128-136.
120. Hay J.E., Malinchoc M., Dickson E.R. A controlled trial of calcitonin therapy for the prevention of post-liver transplantation atraumatic fractures in patients with primary biliary cirrhosis and primary sclerosing cholangitis. J. Hepatol. 2001, 34:292-298.
121. Cremer J., Struber M., Wagenbreth I., Nischelsky J., Demertzis S., Graeter T., Abraham C., Haverich A. Progression of steroid-associated osteoporosis after heart transplantation. Ann. Thorac. Surg. 1999, 67:130-133.
122. Meys E., Terreaux-Duvert F., Beaume-Six T., Dureau G., Meunier P.J. Effects of calcium, calcidiol, and monofluorophosphate on lumbar bone mass and parathyroid function in patients after cardiac transplantation. Osteoporosis. Int. 1993, 3:329-332.
123. Talalaj M., Gradowska L., Marcinowska-Suchowierska E., Durlik M., Gaciong Z., Lao M. Efficiency of preventive treatment of glucocorticoid-induced osteoporosis with 25-hydroxyvitamin D3 and calcium in kidney transplant patients. Transplant. Proc. 1996, 28:3485-3487.
124. Torres J., Garcia S., Gomez A., Gonzalez A., Barrios Y., Concepcion M.T., Hemandez D., Garcia J.J., Checa M.D., Lorenzo V., Salido E. Treatment with intermittent calcitriol and calcium reduces bone loss after renal transplantation. Kidney Int. 2004, 65:705-712.
125. Sambrook P., Henderson N.K., Keogh A., MacDonald P., Glanville A., Spratt P., Bergin P., Ebeling P., Eisman J. Effect of calcitriol on bone loss after cardiac or lung transplantation. J. Bone Miner. Res. 2000, 15:1818-1824.
126. Fan S., Almond M.K., Ball E., Evans K., Cunningham J. Pamidronate therapy as prevention of bone loss following renal transplantation. Kidney Int. 2000, 57:684-690.
127. Fan S.L., Kumar S., Cunningham J. Intravenous pamidronate as treatment for osteoporosis after kidney transplantation: a prospective study. Kidney Int. 2003, 63:2275-2279.
128. Aris R.M., Lester G.E., Renner J.B., Winders A., Blackwood A.D., Lark R.K., Ontjes D.A. Efficacy of pamidronate for osteoporosis in cystic fibrosis patients following lung transplantation. Am. J. Respir. Crit. Care Med. 2000, 162:941.
129. Krieg M., Seydoux C., Sandini L., Goy J.J., Berguer D.G., Thiebaud D., Bruckhardt P. Intravenous pamidronate as a treatment for osteoporosis after heart transplantation: a prospective study. Osteoporos. Int. 2001, 12:112-116.
130. Shane E., Rodino M.A., McMahon D.J., Addesso V., Staron R.B., Seibel M.J., Mancini D., Michler R.E., Lo S.H. Prevention of bone loss after heart transplantation with antiresorptive therapy: a pilot study. J. Heart Lung Transplant. 1998, 17:1089-1096.
131. Reeves H., Francis R., Manas D., Hudson M., Day C. Intravenous bisphosphonate prevents symtomatic osteoporotic vertebral collapse in patients after liver transplantation. Liver Transpl. Surg. 1998, 4:404-409.
132. Coco M., Glicklich D., Faugere M.C., Burris L., Bognar I., Durkin P., Tellis V., Greenstein S., Schechner R., Figueroa K., McDonough P., Wang G., Malluche H. Prevention of bone loss in renal transplant recipients: A prospective randomized trial of intravenous pamidronate. J. Am. Coll. Nephrol. 2003, 14:2669-2676.
133. Kovac D., Lindic J., Kandus A., Bren A.F. Prevention of bone loss in kidney graft recipients. Transplant. Proc. 2001, 33:1144-1145.
134. Schwarz C., Mitterbauer C., Heinze G., Woloszczuk W., Haas M., Oberbauer R. Nonsustained effect of short-term bisphosphonate therapy on bone turnover three years after renal transplantation. Kidney Int. 2004, 65:304-309.
135. Hommann M., Abendroth K., Lehmann G., Patzer N., Kornberg A., Voigt R., Seifert S., Hein G., Scheele J. Effect of transplantation on bone: osteoporosis after liver and multivisceral transplantation. Transplant. Proc. 2002, 34:2296-2298.
136. Grotz W., Nagel C., Poeschel D., Cybulla M., Petersen K.G., Uhl M., Strey C., Kirste G., Olschewski M., Reichelt A., Rump L.C. Effect of ibandronate on bone loss and renal function after kidney transplantation. J. Am. Soc. Nephrol. 2001, 12:1530-1537.
137. Ugur A., Guvener N., Isiklar I., Karakayali H., Erdal R. Efficiency of preventive treatment for osteoporosis after renal transplantation. Transplant. Proc. 2000, 32:556-557.
138. Stempfle H.U., Werner C., Siebert U., Assum T., Wehr U., Rambeck W.A., Meiser B., Theisen K., Gartner R. The role of tacrolimus (FK506)-based immunosuppression on bone mineral density and bone turnover after cardiac transplantation: a prospective, longitudinal, randomized, double-blind trial with calcitriol. Transplantation 2002, 73:547-552.
139. Stempfle H.U., Werner C., Echtler S., Wehr U., Rambeck W.A., Siebert U., Uberfuhr P., Angermann C.E., Theisen K., Gartner R. Prevention of osteoporosis after cardiac transplantation: a prospective, longitudinal, randomized, double-blind trial with calcitriol. Transplantation 1999, 68:523-530.
140. Dodidou P., Bruckner T., Hosch S., Haass M., Klar E., Sauer P., Ziegler R., Leidig-Bruckner G. Better late than never? Experience with intravenous pamidronate treatment in patient with low bone mass or fractures following cardiac or liver transplantation. Osteoporos. Int. 2003, 14:82-88.
141. Idilman R., de Maria N., Uzunalimoglu O., van Thiel D.H. Hepatic osteodystrophy: a review. Hepatogastroenterol 1997, 44:574-581.
142. Grotz W., Rump A.L., Niessen H., Schmidt-Gayt A., Reichelt G., Kirste G., Olchewski G., Schollmeyer P. Treatment of osteopenia and osteoporosis after kidney transplantation. Transplantation 1998, 66:1004-1008.
143. Giannini S., Dangel A., Carraro G., Nobile M., Rigotti P., Bonfante L., Marchini F., Zaninotto M., Dalle Carbonare L., Sartori L., Crepaldi G. Alendronate prevents further bone loss in renal transplant recipients. J. Bone Miner. Res. 2001, 16:2111-2117.
144. Jeffrey J.R., Leslie W.D., Karpinski M.F., Nickerson P.W., Rush D.N. Prevalence and treatment of decreased bone density in renal transplant recipients: a randomized prospective trial of calcitriol versus alendronate. Transplantation 2003, 76:1498-1502.
145. Koc M., Tuglular S., Arikan H., Ozener C., Akoglu E. Alendronate increases bone mineral density in long-term renal transplant recipients. Transplant. Proc. 2002, 34:2111-2113.